Addiction, Second Edition

Addiction to psychoactive drugs found in cigarettes, alcoholic drinks, and opioid analgesics is a severe problem for society. Events associated with addiction-drug abuse, dependence, withdrawal, and relapse-involve complex neurobiological changes in the brain. To develop effective long-term treatment strategies for substance use disorders, a more complete understanding of these brain changes is needed.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive update on our understanding of the biological basis of and treatment strategies for addiction to psychoactive drugs, with an emphasis on opioids. Contributors examine the molecular targets of alcohol, cannabinoids, nicotine, stimulants, and opioids, the resulting changes to the neurocircuitry, and various genetic, environmental, developmental, and behavioral factors that influence the progression from abuse to addiction and susceptibility to relapse. Advances in animal models of addictive behavior and single-cell strategies to dissect neural circuits are also described.

In addition, the authors review compounds currently used or under development to treat substance use disorders, their pharmacological mechanisms, and challenges related to preclinical testing in animal models. This volume is an indispensable reference for all neuroscientists and those who are interested in understanding and reducing the public health burden of drug addiction.

(preliminary)

INTRODUCTION

Addiction Pharmacotherapies
Swinford-Jackson, Pierce, O'Brien, Kenny, L. Vanderschuren

SECTION 1: METHODS AND MODELS
Animal Studies of Addictive Behavior
L. Vandershuren, S. Ahmed
Multi-symptomatic Animal Model
Belin, V. Deroche-Gamonet
Neural Substrates and Circuits of Drug Addiction
Matthew W. Feltenstein, Ronald E. See, Rita A. Fuchs
Optogenetics
Garret Stuber

SECTION 2: PSYCHOSTIMULANTS
Structural Plasticity
S. Golden, S. Russo
Aversive Responses
B. Carlezon, Robble, Wheeler
Synaptic Plasticity
Luscher
Psychostimulant-Induced Adaptations in Nucleus Accumbens Glutamatergic Transmission
William J. Wright and Yan Dong
Epigenetics
Ian Maze
GLP-1 and Addiction
Schmidt, Kenny
Drug-Evoked Synaptic Plasticity of Excitatory Transmission in the Ventral Tegmental Area
Camilla Bellone, Michael Loureiro, and Christian L?scher

SECTION 3: OPIATES
Opioid-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area Dopamine Neurons
Marie A. Doyle and Michelle S. Mazei-Robison
Glutamatergic Systems and Memory Mechanisms Underlying Opioid Addiction
Jasper A. Heinsbroek, Taco J. De Vries, and Jamie Peters
Medications Development for Treatment of Opioid Use Disorder
E.A. Townsend, S.S. Negus, and Matthew L. Banks
Genetic Vulnerability of Opioid Addiction
Brian Reed, Mary Jeanne Kreek
Microbiome
Sabita Roy
Vaccines
Pravetoni
Consequences of Parental Opioid Exposer on Neurophysiology, Behavior, and Health in the Next Generations
Fair Vassoler and Mathiew Wimmer
Neonatal Opioid Withdrawal Syndrome (NOWS): A Transgenerational Echo of the Opioid Crisis
Andrew E. Weller, Richard C. Crist, Benjamin C. Reiner, Glenn A. Doyle, and Wade H. Berrettini

SECTION 4: NICOTINE
Mechanisms of Nicotine Addiction
Marina R. Picciotto and Paul J. Kenny
Adolescent Exposure
Mansvelder
Habenula
Patten, Dani, De Biasi
Translational Research in Nicotine Addiction
Miranda L. Fisher, James Pauly, Brett Froeliger, Jill R. Turner

SECTION 5: ALCOHOL
The Role of the Central Amygdala in Alcohol Dependence
Marisa Roberto, Dean Kirson, and Sophia Khom
Growth Factors and Alcohol Use Disorder
Mirit Liran, Nofar Rahamin, Dorit Ron, and Segev Barak

SECTION 6: CANNABINOIDS
A Brain on Cannabinoids: The Role of Dopamine Release in Reward Seeking and Addiction
Kate Z. Peters, Erik B. Oleson, and Joseph F. Cheer
Impairment of Synaptic Plasticity by Cannabis, Delta-9THC, and Synthetic Cannabinoids
Alexander F. Hoffman, Eun-Kyung Hwang, and Carl R. Lupica

Index