Adrenal Toxicology

Despite being regarded as the most common toxicological target in the endocrine system, the adrenal gland has often been neglected in regulatory testing. Adrenal Toxicologyaddresses the increased interest in adrenocortical toxicology and the need for a resource that makes techniques available to examine adrenal endocrine disruption.Examining current techniques and the latest advancements, Adrenal Toxicologyreviews the endocrinology, pharmacology, and toxicology of the adrenal gland. This text provides information on the range of drugs and chemicals that affect adrenocortical function and suggests standardized approaches for in vivo and in vitro assessment. This volume also presents recent developments in the molecular mechanisms of toxicity.Adrenal Toxicology:

Preface	p. v
Contributors	p. xv
Introduction to Adrenal Toxicology
Adrenal Toxicology: Molecular Targets, Endocrine Mechanisms, Hormonal Interactions, Assessment Models, and Species Differences in Toxicity	p. 3
Hypothalamo-Pituitary-Adrenal Pathophysiology, Endocrinology, and Pharmacology
An Overview of Human Adrenal Dysfunction	p. 39
The Hypothalamo-Pituitary-Adrenocortical Axis: Endocrinology, Pharmacology, Pathophysiology, and Developmental Effects	p. 77
Adrenal Toxicology in Vivo and in Vitro
The Adrenal Medulla as a Target Organ in Toxicologic Studies of Rats and Mice	p. 111
Adrenal Gland Background Pathology of Primates in Toxicological Studies	p. 139
Hypothalamic-Pituitary-Adrenal Toxicity in Dogs	p. 161
Adrenocortical Toxicology In Vitro: Assessment of Steroidogenic Enzyme Expression and Steroid Production in H295R Cells	p. 175
Comparisons of Adrenocortical Cell Lines as In Vitro Test Systems	p. 183
Glucocorticoid Pharmacotoxicological Interactions and Modulation of Toxicity	p. 205
Adrenal Dysfunction in Environmental Sentinel Species
Adrenocortical Toxicology in Fishes	p. 233
Adrenal Toxicology in Birds: Environmental Contaminants and the Avian Response to Stress	p. 257
Index	p. 295
Table of Contents provided by Ingram. All Rights Reserved.

What is included with this book?

The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.

The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.

FREE SHIPPING

Amazon no longer offers textbook rentals. We do!

Summary

Table of Contents

Supplemental Materials