Advanced Molecular Biology: A Concise Reference

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ISBN: 9781859961414 | 185996141X
Cover: Paperback
Copyright: 6/15/1998

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Advanced Molecular Biology emphasises the unifying principles and mechanisms of molecular biology, with frequent use of tables and boxes to summarise experimental data and gene and protein functions. Extensive cross-referencing between chapters is used to reinforce and broaden the understanding of core concepts. This is the ideal source of comprehensive, authoritative and up-to-date information for all those whose work is in the field of molecular biology.

Abbreviations
How to use this book
Preface
Biological Heredity and Variation	p. 1
Mendelian inheritance	p. 1
Segregation at one locus	p. 2
Segregation at two loci	p. 8
Quantitative inheritance	p. 11
The Cell Cycle	p. 21
The bacterial cell cycle	p. 21
The eukaryotic cell cycle	p. 23
The molecular basis of cell cycle regulation	p. 26
Progress through the cell cycle	p. 28
Special cell cycle systems in animals	p. 33
Chromatin	p. 35
Nucleosomes	p. 35
Higher order chromatin organization	p. 38
Chromatin and chromosome function	p. 39
Molecular structure of the bacterial nucleoid	p. 42
Chromosome Mutation	p. 45
Numerical chromosome mutations	p. 45
Structural chromosome mutations	p. 49
Chromosome Structure and Function	p. 57
Normal chromosomes - gross morphology	p. 57
Special chromosome structures	p. 58
Molecular aspects of chromosome structure	p. 60
Development, Molecular Aspects	p. 65
Differentiation	p. 65
Pattern formation and positional information	p. 72
The environment in development	p. 75
DNA Methylation and Epigenetic Regulation	p. 93
DNA methylation in prokaryotes	p. 93
DNA methylation in eukaryotes	p. 94
Epigenetic gene regulation by DNA methylation in mammals	p. 97
The Gene	p. 103
The concept of the gene	p. 103
Units of genetic structure and genetic function	p. 104
Gene-cistron relationship in prokaryotes and eukaryotes	p. 104
Gene structure and architecture	p. 106
Gene Expression and Regulation	p. 111
Gene expression	p. 112
Gene regulation	p. 113
Gene expression in prokaryotes and eukaryotes	p. 115
Gene Transfer in Bacteria	p. 117
Conjugation	p. 117
Transformation	p. 119
Transduction	p. 120
The Genetic Code	p. 127
An overview of the genetic code	p. 127
Translation	p. 127
Special properties of the code	p. 129
Genomes and Mapping	p. 133
Genomes, ploidy and chromosome number	p. 134
Physico-chemical properties of the genome	p. 134
Genome size and sequence components	p. 135
Gene structure and higher-order genome organization	p. 136
Repetitive DNA	p. 139
Isochore organization of the mammalian genome	p. 143
Gene mapping	p. 144
Genetic mapping	p. 146
Physical mapping	p. 151
Mobile Genetic Elements	p. 165
Mechanisms of transposition	p. 166
Consequences of transposition	p. 172
Transposons	p. 175
Retroelements	p. 180
Mutagenesis and DNA Repair	p. 183
Mutagenesis and replication fidelity	p. 183
DNA damage: mutation and killing	p. 185
DNA repair	p. 187
Direct reversal repair	p. 187
Excision repair	p. 191
Mismatch repair	p. 194
Recombination repair	p. 197
The SOS response and mutagenic repair	p. 197
Mutation and Selection	p. 201
Structural and functional consequences of mutation	p. 201
Mutant alleles and the molecular basis of phenotype	p. 209
The distribution of mutations and molecular evolution	p. 211
Mutations in Genetic Analysis	p. 213
Nucleic Acid Structure	p. 223
Nucleic acid primary structure	p. 223
Nucleic acid secondary structure	p. 226
Nucleic acid tertiary structure	p. 231
Nucleic Acid-Binding Properties	p. 235
Nucleic acid recognition by proteins	p. 236
DNA-binding motifs in proteins	p. 237
RNA-binding motifs in proteins	p. 243
Molecular aspects of protein-nucleic acid binding	p. 244
Sequence-specific binding	p. 246
Techniques for the study of protein-nucleic acid interactions	p. 249
Oncogenes and Cancer	p. 253
Oncogenes	p. 254
Tumor-suppressor genes	p. 258
Organelle Genomes	p. 263
Organelle genetics	p. 263
Organelle genomes	p. 264
Plasmids	p. 271
Plasmid classification	p. 271
Plasmid replication and maintenance	p. 273
The Polymerase Chain Reaction (PCR)	p. 279
Specificity of the PCR reaction	p. 279
Advances and extensions to basic PCR strategy	p. 283
Alternative methods for in vitro amplification	p. 284
Proteins: Structure, Function and Evolution	p. 287
Protein primary structure	p. 288
Higher order protein structure	p. 289
Protein modification	p. 295
Protein families	p. 297
Global analysis of protein function	p. 304
Protein Synthesis	p. 313
The components of protein synthesis	p. 313
The mechanism of protein synthesis	p. 315
The regulation of protein synthesis	p. 318
Recombinant DNA and Molecular Cloning	p. 323
Molecular cloning	p. 324
Strategies for gene isolation	p. 331
Characterization of cloned DNA	p. 336
Expression of cloned DNA	p. 339
Analysis of gene regulation	p. 342
Analysis of proteins and protein-protein interactions	p. 345
In vitro mutagenesis	p. 346
Transgenesis: gene transfer to animals and plants	p. 348
Recombination	p. 369
Homologous recombination	p. 369
Homologous recombination and genetic mapping	p. 373
Random and programmed nonreciprocal recombination	p. 376
Site specific recombination	p. 378
Generation of immunoglobulin and T-cell receptor diversity	p. 379
Illegitimate recombination	p. 382
Replication	p. 389
Replication strategy	p. 389
The cellular replisome and the enzymology of elongation	p. 392
Initiation of replication	p. 400
Primers and priming	p. 404
Termination of replication	p. 404
The regulation of replication	p. 406
RNA Processing	p. 411
Maturation of untranslated RNAs	p. 411
End-modification and methylation of mRNA	p. 412
RNA splicing	p. 414
RNA editing	p. 421
Post-processing regulation	p. 421
Signal Transduction	p. 425
Receptors and signaling pathways	p. 425
Intracellular enzyme cascades	p. 431
Second messengers	p. 434
Signal delivery	p. 440
Transcription	p. 443
Principles of transcription	p. 443
Transcriptional initiation in prokaryotes - basal and constitutive components	p. 445
Transcriptional initiation in eukaryotes - basal and constitutive components	p. 447
Transcriptional initiation - regulatory components	p. 450
Strategies for transcriptional regulation in bacteria and eukaryotes	p. 456
Transcriptional elongation and termination	p. 458
Viruses and Subviral Agents	p. 467
Viral infection strategy	p. 468
Diversity of replication strategy	p. 469
Strategies for viral gene expression	p. 475
Subviral agents	p. 477
Index	p. 489
Table of Contents provided by Blackwell. All Rights Reserved.

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Advanced Molecular Biology: A Concise Reference

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