Advanced Molecular Biology

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ISBN: 9780387915982 | 0387915982
Cover: Paperback
Copyright: 12/1/1999

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This well organized reference provides clear and concise explanations of the terminology used in molecular biology and genetics. It covers key areas such as the cell cycle, organelles and plasmids, replication and recombination, transcription, gene expression and regulation, and PCR. In addition, DNA, RNA and chromosomes are covered, including their structure, function, modification, mutation and repair.

Abbreviations

How to use this book

xii

Preface

xii

Biological Heredity and Variation

(20)

Mendelian inheritance

(1)

Segregation at one locus

(6)

Segregation at two loci

(3)

Quantitative inheritance

(10)

The Cell Cycle

(14)

The bacterial cell cycle

(2)

The eukaryotic cell cycle

(3)

The molecular basis of cell cycle regulation

(2)

Progress through the cell cycle

(5)

Special cell cycle systems in animals

(2)

Chromatin

(10)

Nucleosomes

(3)

Higher order chromatin organization

(1)

Chromatin and chromosome function

(3)

Molecular structure of the bacterial nucleoid

(3)

Chromosome Mutation

(12)

Numerical chromosome mutations

(4)

Structural chromosome mutations

(8)

Chromosome Structure and Function

(8)

Normal chromosomes -- gross morphology

(1)

Special chromosome structures

(2)

Molecular aspects of chromosome structure

(5)

Development, Molecular Aspects

(28)

Differentiation

(7)

Pattern formation and positional information

(3)

The environment in development

(18)

DNA methylation and Epigenetic Regulation

(10)

DNA methylation in prokaryotes

(1)

DNA methylation in eukaryotes

(3)

Epigenetic gene regulation by DNA methylation in mammals

(6)

The Gene

103

(8)

The concept of the gene

103

(1)

Units of genetic structure and genetic function

104

(1)

Gene-cistron relationship in prokaryotes and eukaryotes

104

(2)

Gene structure and architecture

106

(5)

Gene Expression and Regulation

111

(6)

Gene expression

112

(1)

Gene regulation

113

(2)

Gene expression in prokaryotes and eukaryotes

115

(2)

Gene Transfer in Bacteria

117

(10)

Conjugation

117

(2)

Transformation

119

(1)

Transduction

120

(7)

The Genetic Code

127

(6)

An overview of the genetic code

127

(1)

Translation

127

(2)

Special properties of the code

129

(4)

Genomes and Mapping

133

(32)

Genomes, ploidy and chromosome number

134

(1)

Physico-chemical properties of the genome

134

(1)

Genome size and sequence components

135

(1)

Gene structure and higher-order genome organization

136

(3)

Repetitive DNA

139

(4)

Isochore organization of the mammalian genome

143

(1)

Gene mapping

144

(2)

Genetic mapping

146

(5)

Physical mapping

151

(14)

Mobile Genetic Elements

165

(18)

Mechanisms of transposition

166

(6)

Consequences of transposition

172

(3)

Transposons

175

(5)

Retroelements

180

(3)

Mutagenesis and DNA Repair

183

(18)

Mutagenesis and replication fidelity

183

(2)

DNA damage: mutation and killing

185

(2)

DNA repair

187

(1)

Direct reversal repair

187

(4)

Excision repair

191

(3)

Mismatch repair

194

(3)

Recombination repair

197

(1)

The SOS response and mutagenic repair

197

(4)

Mutation and Selection

201

(22)

Structural and functional consequences of mutation

201

(8)

Mutant alleles and the molecular basis of phenotype

209

(2)

The distribution of mutations and molecular evolution

211

(2)

Mutations in Genetic Analysis

213

(10)

Nucleic Acid Structure

223

(12)

Nucleic acid primary structure

223

(3)

Nucleic acid secondary structure

226

(5)

Nucleic acid tertiary structure

231

(4)

Nucleic Acid-Binding Properties

235

(18)

Nucleic acid recognition by proteins

236

(1)

DNA-binding motifs in proteins

237

(6)

RNA-binding motifs in proteins

243

(1)

Molecular aspects of protein-nucleic acid binding

244

(2)

Sequence-specific binding

246

(3)

Techniques for the study of protein-nucleic acid interactions

249

(4)

Oncogenes and Cancer

253

(10)

Oncogenes

254

(4)

Tumor-suppressor genes

258

(5)

Organelle Genomes

263

(8)

Organelle genetics

263

(1)

Organelle genomes

264

(7)

Plasmids

271

(8)

Plasmid classification

271

(2)

Plasmid replication and maintenance

273

(6)

The Polymerase Chain Reaction (PCR)

279

(8)

Specificity of the PCR reaction

279

(4)

Advances and extensions to basic PCR strategy

283

(1)

Alternative methods for in vitro amplification

284

(3)

Proteins: Structure, Function and Evolution

287

(26)

Protein primary structure

288

(1)

Higher order protein structure

289

(6)

Protein modification

295

(2)

Protein families

297

(7)

Global analysis of protein function

304

(9)

Protein Synthesis

313

(10)

The components of protein synthesis

313

(2)

The mechanism of protein synthesis

315

(3)

The regulation of protein synthesis

318

(5)

Recombinant DNA and Molecular Cloning

323

(46)

Molecular cloning

324

(7)

Strategies for gene isolation

331

(5)

Characterization of cloned DNA

336

(3)

Expression of cloned DNA

339

(3)

Analysis of gene regulation

342

(3)

Analysis of proteins and protein-protein interactions

345

(1)

In vitro mutagenesis

346

(2)

Transgenesis: gene transfer to animals and plants

348

(21)

Recombination

369

(20)

Homologous recombination

369

(4)

Homologous recombination and genetic mapping

373

(3)

Random and programmed nonreciprocal recombination

376

(2)

Site specific recombination

378

(1)

Generation of immunoglobulin and T-cell receptor diversity

379

(3)

Illegitimate recombination

382

(7)

Replication

389

(22)

Replication strategy

389

(3)

The cellular replisome and the enzymology of elongation

392

(8)

Initiation of replication

400

(4)

Primers and priming

404

(1)

Termination of replication

404

(2)

The regulation of replication

406

(5)

RNA Processing

411

(14)

Maturation of untranslated RNAs

411

(1)

End-modification and methylation of mRNA

412

(2)

RNA splicing

414

(7)

RNA editing

421

(1)

Post-processing regulation

421

(4)

Signal Transduction

425

(18)

Receptors and signaling pathways

425

(6)

Intracellular enzyme cascades

431

(3)

Second messengers

434

(6)

Signal delivery

440

(3)

Transcription

443

(24)

Principles of transcription

443

(2)

Transcriptional initiation in prokaryotes -- basal and constitutive components

445

(2)

Transcriptional initiation in eukaryotes -- basal and constitutive components

447

(3)

Transcriptional initiation -- regulatory components

450

(6)

Strategies for transcriptional regulation in bacteria and eukaryotes

456

(2)

Transcriptional elongation and termination

458

(9)

Viruses and Subviral Agents

467

(22)

Viral infection strategy

468

(1)

Diversity of replication strategy

469

(6)

Strategies for viral gene expression

475

(2)

Subviral agents

477

(12)

Index

489

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Advanced Molecular Biology

Summary

Table of Contents

Supplemental Materials