Aicardi's Diseases of the Nervous System in Childhood

Congenital or early-onset disorders of the nervous system have a profound and lifelong impact on the lives of children and their families.  Diseases of the Nervous System in Childhood provides up-to-date information on the full range of these neurological disorders, from fetal and neonatal neurology to adolescence.

Movement disorders, epilepsies and seizure disorders, metabolic diseases, auditory and visual disorders, and genetic anomalies are among the many topics covered in this text.  Extensive reference lists at the end of each chapter guide the clinician to further relevant reading.

This fourth edition retains the patient-focussed, clinical approach of its predecessors. The international team of editors and contributors has honoured the request of the late Jean Aicardi, that his book remain ‘resolutely clinical’, which distinguishes Diseases of the Nervous System in Childhood from other texts in the field.

This edition:

• Is completely revised and updated
• Includes latest developments in genetic advances
• Contains new chapters on basal ganglia diseases and psychogenic disorders
• Has an easy-to-use one volume format with full-colour illustrations

Alexis Arzimanoglou is the Director of the Paediatric Epilepsy and Functional Neurology Department at the University Hospitals of Lyon, France and Visiting Professor at the Universitat de Barcelona, Spain, coordinating the Epilepsy Research Program at the Hospital San Juan de Dios. He trained in Neurology at Great Ormond Street, London, UK and at the Hôpital de la SALPETRIERE and in Child Neurology as a fellow of Jean AICARDI at the Hôpital des Enfants Malades in Paris, France. He then with worked with Jean Aicardi for over 25 years. He served as Chair of the Scientific Committee of the European Paediatric Neurology Society, elected member of the European Commission of the International League Against Epilepsy (ILAE) and President of the Société Européenne de Neurologie. He is currently as International League Against Epilepsy Ambassador for Epilepsy for the ILAE, Editor-in-Chief of  the ILAE Educational Journal, Epileptic Disorders and  Associate Editor of the European Journal of Paediatric Neurology, official journal of the European Paediatric Neurology Society. He is the author of two books, editor of seven and an author or co-author of over one hundred scientific articles.

Anne O'Hare is Professor of Community Paediatrics and Director of the Salvesen Mindroom Centre for Learning Difficulties, at the University of Edinburgh, UK. She is a developmental paediatrician with extensive clinical experience in neurodisability, neuroscience and child protection. Her research interests include how neurodevelopmental conditions impact on the development of speech, language, communication, motor skills and learning and the development of effective interventions. She has co-edited and contributed to numerous book chapters and articles in her field.

Michael Johnston is Professor of Neurology, Paediatrics and Physical Medicine and Rehabilitation at the Johns Hopkins University School of Medicine and the Chief Medical Officer and Blum Moser Endowed Professor of Paediatric Neurology at the Kennedy Krieger Institute in Baltimore, Maryland, USA. His clinical and research interests include fetal and neonatal neurology, as well as care for older children with cerebral palsy and neurogenetic disorders. He has received the Bernard Sachs award from the Child Neurology Society and the Frank Ford Lecture Award from the International Child Neurology Association (ICNA) as well as the Jacob Javits Neuroscience Investigator Award from the National Institutes of Health.

Robert Ouvrier is Emeritus Professor of Child Neurology at the University of Sydney, Australia. After training in general paediatrics in Sydney, Perth and Papua-New Guinea, he undertook specialist training in child neurology at the Royal Children's Hospital, Melbourne, the University of Kentucky (1969-70) and the Johns Hopkins Hospital, Baltimore USA (1971-72). He was Head of the Department of Neurology at the Children's Hospital at Westmead, Sydney for 25 years. In 1999, he became the Foundation Head of the Institute for Neuroscience and Muscle Research at The Children's Hospital, Westmead. He was President of the International Child Neurology Association from 2006-2010. He is the author of two books, 30 book chapters and an author or co-author of over 150 scientific articles on paediatric neurology.

Jean Aicardi (1926–2015)

Jean Aicardi: A Brief Curriculum Vitae

About the Editors

Authors’ Appointment

Preface to Third Edition

Preface to Fourth Edition

Acknowledgements

PART 1: FETAL AND NEONATAL NEUROLOGY

1. Fetal Neurology

Adré J Du Plessis and Michael V Johnston

2. Neurological Diseases in the Perinatal Period

Miriam Martinez-Biarge and Linda S de Vries

PART 2: BRAIN MALFORMATIONS, NEUROCUTANEOUS SYNDROMES, GENETIC ANOMALIES and DYSMORPHIC SYNDROMES

3. Developmental Brain Malformations

Nadia Bahi-Buisson and Nathalie Boddaert

4. Neurocutaneous Diseases and Syndromes

Eleni Panagiotakaki and Alexis Arzimanoglou

5. Genetic Anomalies and Dysmorphic Syndromes

Karine Pelc and Bernard Dan

PART 3: NEUROLOGICAL CONSEQUENCES OF PRENATAL, PERINATAL AND EARLY POSTNATAL INTERFERENCE WITH BRAIN DEVELOPMENT

6. Osseous Malformations of the Skull and Craniovertebral Junction

Richard Hayward and Dominic Thompson

7. Hydrocephalus and Non-traumatic Pericerebral Collections

Andrew Whitelaw and Christian Sainte-Rose

8. Cerebral Palsy and Related Movement Disorders

Ingeborg Krägeloh-Mann

PART 4: METABOLIC AND HEREDODEGENERATIVE DISORDERS

9. Metabolic Diseases

Linda De Meirleir

10. Heredodgenerative Disorders

Victoria San Antonio, Jaume Campistol Plana, Alexis Arzimanoglou and Robert Ouvrier

PART 5: POSTNATAL EXTRINSIC INSULTS

11. Infectious Diseases

Michael Eyre, Alasdair Bamford and Cheryl Hemingway

12. Parainfectious and Other Inflammatory Disorders of Immunological Origin

Marc Tardieu and Michael Johnston

13. Accidental and Non-Accidental Injuries by Physical and Toxic Agents

Karen Barlow, Robert Forsyth and Robert Minns

PART 6: TUMOURS AND VASCULAR DISORDERS

14. Tumours of the Central Nervous System, Other Space-Occupying Lesions and Pseudotumour Cerebri

Colin Kennedy, Aabir Chakraborty and David Walker

15. Cerebrovascular Disorders

Gabrielle deVeber and Adam Kirton

PART 7: PAROXYSMAL DISORDERS

16. Epilepsy and Other Seizure Disorders

Alexis Arzimanoglou and Michael S Duchowny

17. Headache Disorders in Children

Kenneth J Mack

18. Sleep Disorders

Patricia Franco

PART 8: MOVEMENT DISORDERS

19. Basal Ganglia Disorders and Movement Disorders

Paddy Grattan-Smith, Russell C Dale and Emilio Fernandez-Alvarez

20. Tics and Gilles de la Tourette Syndrome

Robert Ouvrier and Russell C Dale

21. Non-Epileptic Paroxysmal Movement Disorders

Paddy Grattan-Smith, Russell C Dale and Emilio Fernandez-Alvarez

PART 9: DISORDERS OF THE OCULOMOTOR, VISUAL, AUDITORY AND VESTIBULAR SYSTEMS

22. Disorders of Visual and Oculomotor Functions

Carey Matsuba

23. Disorders of Auditory and Vestibular Functions

Anne O’Hare

PART 10: NEUROMUSCULAR DISEASES

24. Diseases of the Motor Neuron

Mariacristina Scoto and Francesco Muntoni

25. Disorders of the Peripheral Nerves

Manoj Menezes and Robert Ouvrier

26. Muscle Disorders

Monique M Ryan, Francesco Muntoni and Kathryn N North

PART 11: NEUROLOGICAL MANIFESTATIONS OF SYSTEMIC DISEASES

27. Electrolyte and Acid-Base Metabolism Disturbances, Nutritional Disorders and Other Systemic Diseases

Peter Baxter

PART 12: DEVELOPMENTAL AND NEUROPSYCHIATRIC DISORDERS OF CHILDHOOD

28. Neurodevelopmental Disabilities and their Management

Bruce K Shapiro

29. Autism Spectrum Disorder and Autistic-Like Conditions

Anne O'Hare and Roberto Tuchman

30. Attention-Deficit–Hyperactivity Disorder and Co-existing Impairments

Bruce K Shapiro

31. Disorders of Speech, Language and Communication

Anne O'Hare

32. Psychogenic Neurological Disorders

Paddy Grattan-Smith

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