Anticancer Agents Frontiers in Cancer

Describes cutting edge approaches in the development of anticancer agents for chemotherapy. These new and interdisciplinary approaches are aimed at the development of tumor specific anticancer agents while increasing the potency against drug-resistant tumors. The volume includes an overview of new paradigms for cancer drug discovery and development by NCI, new generation cytotoxic agents, mechanism based enzyme inhibitors as anticancer agents, anti-angiogenesis agents, antitumor vaccines, and tumor activated prodrugs using immunoconjugates of monoclonal antibodies with cytotoxic agents.

Preface
Cancer Drug Discovery and Development: New Paradigms for a New Millennium
Evolutionary Biosynthesis of Anticancer Drugs
Some Recent Developments in the Synthesis and SAR of Novel Taxanes
New Generation Taxoids and Hybrids of Microtube-Stabilizing Anticancer Agents
Discodermolide and Taxol: A Synergistic Drug Combination in Human Carcinoma Cell Lines
Highly Efficient Semisynthesis of Biologically Active Epothilone Derivatives
Synthetic and Semisynthetic Analogs of Epothilones: Chemistry and Biological Activity
Synthesis and Biological Activity of Epothilones
Epothelones and Sarcodictyins: From Combinatorial to Designed Analogs
Synthesis and Structure-Activity Relationship Studies of Cryptophycins: A Novel Class of Potent Antimitotic Tumor Depsipeptides
Farnesyltransferase Inhibitors as Potential Anticancer Agents
Farnesyltransferase Inhibitors: From Squalene Synthase Inhibitors to the Clinical Agent BMS-214662
Inhibiting Farnesyl Protein Transferase with Sch-66336: Potentially a Selective Non-Cytotoxic herapy for Human Cancer
Pyrrolo[2,3-d]pyrimidine and Pyrazolo[3,4-d]pyrimidine Derivatives as Selective Inhibitors of the EGF Receptor Tyrosine Kinase
STI571: A New Treatment Modality for CML
The Discovery and De
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Anticancer Agents Frontiers in Cancer Chemotherapy

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