Antipsychotic Trials in Schizophrenia: The CATIE Project

Antipsychotic medications are a key treatment for schizophrenia and sales of antipsychotic drugs approach $20 billion per year, with fierce marketing between the makers of the drugs. The U.S. National Institute of Mental Health sponsored the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project to provide independent information about the comparative effectiveness of medications. CATIE was the largest, longest and most comprehensive study of schizophrenia to date. Conducted under rigorous double-blind conditions, Antipsychotic Trials in Schizophrenia presents the definitive archival results of this landmark study. The core of the book consists of chapters focused on specific outcomes that set the CATIE findings in a wider context. Also included are chapters on the design, statistical analyses and implications for researchers, clinicians and policy makers. Psychiatrists, psychiatric researchers, mental health policy makers and those working in pharmaceutical companies will all find this to be essential reading.

T. Scott stroup is Director of the Program for Intervention Effectiveness Research in the Department of Psychiatry, Columbia University, College of Physicians and Surgeons, and the New York State Psychiatric Institute, New York, USA.
Jeffrey A. Lieberman is Chairman, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, Director, New York State Psychiatric Institute, Director, Lieber Center for Schizophrenia Research, and Psychiatrist-in-chief at New York Presbyterian Hospital and Columbia University Medical Center, New York, USA.