Asymmetric Organocatalysis New Strategies, Catalysts, and Opportunities, 2 Volumes

Comprehensive resource on the latest and most important developments in the highly vivid field of asymmetric organocatalysis

The book provides a comprehensive overview of the most important advancements in the field of asymmetric organocatalysis that have occurred within the last decade. It presents valuable examples of newly developed synthetic methodologies based on various organocatalytic activation modes.

Special emphasis is given to strategies where organocatalysis is expanding its potential by pushing the boundaries and founding new synergistic interactions with other fields of synthetic chemistry, such as metal catalysis, photocatalysis, and biocatalysis. The application of different concepts (such as vinylogy, dearomatization, or cascade reactivity), resulting in the development of new functionalization strategies, is also discussed. Sample topics covered within the book include:

• New developments in enantioselective Brønsted acid catalysis with strong hydrogen-bond donors
• Asymmetric phase-transfer catalysis, from classical applications to new concepts
• Halogen-bonding organocatalysis
• Asymmetric electrochemical organocatalysis and synergistic organo-organocatalysis
• Immobilized organocatalysts for enantioselective continuous flow processes
• Mechanochemistry and high-pressure techniques in asymmetric organocatalysis
• Useful tools in elucidation of organocatalytic reaction mechanisms

With an overall focus on new reactions and catalysts, this two-volume work is an indispensable source for everyone working in the field of asymmetric organocatalysis.

Lukasz Albrecht is full professor and group leader at the Institute of Organic Chemistry at Lodz University of Technology, Poland. His research deals with the synthesis and utilization of chiral organic catalysts.

Anna Albrecht is associate professor at Lodz University of Technology, Poland. In 2020, she accomplished her habilitation working on the development of new decarboxylative synthetic strategies.

Luca Dell'Amico is associate professor at Padova University, Italy. His current research spans from the development of stereoselective photochemical processes to the investigation of novel organocatalytic methods using renewables.

Part I. New Catalysts and Activation Strategies in Asymmetric Organocatalysis

New Developments in Enantioselective Brønsted Acid Catalysis with Strong Hydrogen-Bond Donors

Organosuperbases - Moving beyond Classical Brønsted Base Catalysis

Asymmetric Phase-Transfer Catalysis - From Classical Applications to New Concepts

Asymmetric Ion-Pairing & H-Bonding Catalysis

Isothiourea Catalysis - New Opportunities for Asymmetric Synthesis

Halogen-Bonding Organocatalysis - New Opportunities for Asymmetric Synthesis

Merging Organocatalysis with Light - New Opportunities for Asymmetric Synthesis

Asymmetric Electrochemical Organocatalysis - New Opportunities for Synthesis

Synergistic Organo-Organocatalysis

Merging Organocatalysis with Metals - New Opportunities for Asymmetric Synthesis

Immobilized Organocatalysts for Enantioselective Continuous Flow Processes

Mechanochemistry and High-Pressure Techniques in Asymmetric Organocatalysis

Organocatalytic Reactions under Non-Traditional Conditions

Part II. New Organocatalytic Synthetic Methodologies

Merging Organocatalysis with Vinylogy - New Opportunities for Asymmetric Synthesis

Umpolung Organocatalytic Strategies - Beyond Classical Reactivity Patterns

Dearomative Organocatalytic Strategies

From Organocatalytic Cycloadditions to Asymmetric Higher-Order Cycloadditions

Asymmetric Organocatalysis - From a Process Development Perspective

Part III. Mechanisms of Organocatalytic Reactions

Computational Studies - A Useful Tool in Elucidation of Mechanisms of Organocatalytic Reactions

A Tutorial on Kinetic-Assisted Mechanistic Analysis in Asymmetric Aminocatalysis

Mayr Linear Free Energy Relationship: A Powerful Tool for Understanding Aminocatalyzed Reactions

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