Autoimmunity, Part A Basic Principles and New

The incidence of autoimmune diseases is increasing worldwide, and the search for better management of these diseases and even for a cure is being pursued by scientists from many disciplines. Tools from the areas of genetics, neuroscience, cell biology, virology, and infectious disease are being applied to the problem and are yielding useful results.This volume contains the first section of the proceedings of a large, comprehensive meeting held in Sorrento, Italy. Because the meeting focused on such an important area of human health, four volumes have been dedicated to it: Part A presents new principles in autoimmunity, including the roles of key players such as designed ankyrin repeat proteins, SLAM-associated protein, interleukin-12, human proteinase 3, the complement system, IgG, disturbances in cytokine synthesis, and IFN-Î³ blockers. The second section of the volume takes a look at new diagnostic tools, including screening of endothelial expression libraries, electrical skin impedance, and IgA anti-tissue transglutaminase antibody assays.Autoimmunity, Part B continues the presentation of basic research and its applications with a focus on genetics. Parts C and D present the clinical research in various manifestations of autoimmune disease and its treatments.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

M. Eric Gershwin is the editor of Autoimmunity, Part A: Basic Principles and New Diagnostic Tools, Volume 1109, published by Wiley. Yehuda Shoenfeld is an Israeli physician and autoimmunity researcher.

Foreword
New Principles of Autoimmunity
The Nature and Nurture of Common Autoimmunity
Designed Ankyrin Repeat Proteins as Anti-Idiotypic Binding Molecules
SLAM-Associated Protein (SAP) Solves a Mystery of Autoimmunity
Standardization of Autoimmune Diagnostics in Germany - Activities of the German Group in the European Autoimmune Standardisation Initiative
Autoimmunity and Time Entanglement
The Pro- and Anti-Inflammatory Potential of Interleukin-12
NKG2D and Natural Cytotoxicity Receptors Are Involved in Natural Killer Cell Interaction with Self-Antigen Presenting Cells and Stromal Cells
The Role of Toll-Like Receptors in HMGB1 Release from Macrophages
Immune Complex Pathophysiology
Human Proteinase 3 (PR3) and Its Binding Molecules: Implications for Inflammatory and PR3-Related Autoimmune Responses
Loss of Self-Control in the Complement System and Innate Autoreactivity
Immunodeficiency and Autoimmune Phenomena in Female Hyper IgM Syndrome (HIGM)
Autoimmune Diseases of Domestic Animals
Prediction and Prevention of Autoimmune Disease: A Personal Perspective
Alterations of Th1/Th2 Reactivity by Heavy Metals: Possible Consequences Include Induction of Autoimmune Diseases
EASI - The European Autoimmunity Standardisation Initiative: A New Initiative That Can Contribute to Agreed Diagnostic Models of Diagnosing Autoimmune Disorders Throughout Europe
Effector Memory CD8+ T Cells Are Resistant to Apoptosis
Two-Step Mechanism of Virus-Induced Autoimmune Hemolytic Anemia
Autoimmune Reactions After Electro-Oxidation of IgG from Healthy Persons
Relevance of Electric Current and Antioxidants
Autoimmune Diseases Are Connected With Disturbances In Cytokine Synthesis and Therapy With IFN-g Blockers Is Their Main Pathogenetic Treatment
New Tools in Diagnosis
Screening of Endothelial Expression Libraries for the Identification of Novel Autoantigens Involved in Distinct Autoimmune Diseases Characterized by Endothelial Dysfunction
Diagnosing Diseases by Mesurement of Electrical Skin Impedance: A Novel Technique
Antigen Preparation for Immunological Studies in Systemic Autoimmune Diseases
Comparison of Two Elisa Assays for Anti-SP100 Determination
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Autoimmunity, Part A Basic Principles and New Diagnostic Tools, Volume 1109

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