| Preface |
|
ix | |
| KEYNOTE ADDRESS |
|
|
Delving into the Streptomyces chromosome |
|
|
1 | (8) |
|
|
|
|
|
| PART 1: MICROBIAL GENOMICS |
|
|
Whole genome sequencing at The Institute for Genomic Research (TIGR) |
|
|
9 | (4) |
|
|
|
|
|
|
Streptococcus pneumoniae genome sequence sampling |
|
|
13 | (8) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Comparative genome analysis: From sequences to functions |
|
|
21 | (6) |
|
|
|
|
|
| PART 2: POLYKETIDES |
|
|
Genetic and functional characterization of the sterigmatocystin gene cluster |
|
|
27 | (6) |
|
|
|
|
|
|
|
|
|
|
|
Rational engineering of complex polyketide biosynthesis--Where do we begin? |
|
|
33 | (8) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Relationships between the fatty acid and polyketide synthases of Streptomyces coelicolor |
|
|
41 | (6) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| PART 3: BIODIVERSITY |
|
|
Toward the future of microbial biology: Opportunity for an environmental genome survey |
|
|
47 | (8) |
|
|
|
|
|
|
The microbial ecology of bacterial diseases |
|
|
55 | (2) |
|
|
|
|
|
|
Molecular diversity of polyketide biosynthesis genes in lichens |
|
|
57 | (4) |
|
|
|
|
|
|
|
|
|
|
|
Panning microbial diversity for novel catalytic activities |
|
|
61 | (6) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| PART 4: ENGINEERED MICROBIAL PRODUCTS |
|
|
Directed evolution of enzymes |
|
|
67 | (4) |
|
|
|
|
|
|
|
|
|
|
|
Diverse bioactivities from actinomycete combinatorial biology libraries |
|
|
71 | (8) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| PART 5: CYCLIC PEPTIDES |
|
|
Structural model of acyl carrier domains in integrated biosynthetic systems forming peptides, polyketides and fatty acids based on analogy to the E. coli acyl carrier protein |
|
|
79 | (10) |
|
|
|
|
|
|
|
|
|
|
|
Organization and regulation of a siderophore gene cluster in Ustilago maydis |
|
|
89 | (4) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Genetics of lipopeptide antibiotic biosynthesis in Streptomyces fradiae A54145 and Streptomyces roseoporus A21978 |
|
|
93 | (8) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| PART 6: NOVEL MICROBIAL PRODUCTS |
|
|
Biosynthesis of antibiotics |
|
|
101 | (8) |
|
|
|
|
|
|
Glycosyl transfer during tylosin production in Streptomyces fradiae |
|
|
109 | (6) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Glycosyltransferase genes fro Amycolatopsis orientalis and their use to produce novel glycopeptide antibiotics |
|
|
115 | (8) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Cellular self-protection against the antitumor antibiotic mitomycin in Streptomyces lavendulae |
|
|
123 | (10) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| PART 7: GENE REGULATION |
|
|
Septum formation during sporulation of Streptomyces griseus |
|
|
133 | (6) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Appendix: Poster abstracts |
|
139 | (15) |
| Author index |
|
154 | |
