| Preface |
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| I Lipoxygenases and Leukotriene Biosynthesis |
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Phosphorylation and Activation of 5-Lipoxygenase by P38 Kinase-Activated MAPKAP Kinases |
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1 | (8) |
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5-Lipoxygenase and the Nucleus: Where, When, How, and Why? |
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9 | (8) |
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Calcium Binding Site of 5-Lipoxygenase |
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17 | (4) |
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Regulation of Cellular 5-Lipoxygenase Activity by Glutathione Peroxidases |
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21 | (4) |
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Novel Aspects Related to Biosynthesis and Biological Actions of Hepoxilins: Interrelationship with Phospholipid Hydro-Peroxide Glutathione Peroxidase (PHGPx) |
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25 | (6) |
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Transcriptional Regulation of the Human Leukotriene C4 Synthase Promoter |
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31 | (6) |
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Localization and Translocation of Enzymes Involved in Leukotriene Biosynthesis |
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37 | (4) |
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| II Cyclooxygenases and Prostaglandin Biosynthesis |
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Regulation of COX-2 Expression in Fibroblasts, Osteoblasts, Mast Cells, and Macrophages |
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41 | (8) |
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Antimicroinflammatory Lipid Signals from Vascular Cyclooxygenase-2: A Novel Mechanism for NSAID and N-3 PUFA Therapeutic Actions |
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49 | (8) |
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Substrate Interactions in the Cyclooxygenase-1 Active Site |
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57 | (8) |
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Mutation of the Human Prostacyclin Synthase Gene |
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65 | (4) |
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Structure and Function of Two Distinct Types of Prostaglandin D Synthase |
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69 | (4) |
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Roles of Prostaglandin F Synthase |
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73 | (4) |
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Differential Effects of Nitric Oxide on Cyclooxygenase 1 and 2 Activities in Cultured Cells |
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77 | (4) |
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| III Phospholipase A2 |
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On the Functional Diversity of Secreted Phospholipases A2: Cloning of Novel Mammalian and HIV-1 Antiviral Properties |
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81 | (4) |
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Regulation of Cytosolic Phospholipase A2 by Phosphorylation |
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85 | (4) |
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| IV Cytochrome P450 Archidonate Metabolites |
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Synthesis and Function of 20-Hydroxyeicosatetraenoic Acid in the Kidney |
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89 | (10) |
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| V Receptors |
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Altered Bronchodilation and Pulmonary Inflammation in Prostanoid EP2 Receptor Knockout Mice |
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99 | (4) |
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Induction of Prostaglandin I2 Receptor in Murine Osteoblastic Cell |
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103 | (4) |
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BLT2, a Second Leukotriene B4 Receptor |
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107 | (4) |
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Upregulation of Cysteinyl-Leukotriene 1 Receptor Expression by Interleukin-5 in Human Leukocytes |
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111 | (4) |
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Physiological and Pathophysiological Roles of Prostanoids; Lessons from Receptor-Knockout Mice for Clinical Applications |
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115 | (6) |
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Multiple G-Protein Coupling of Chimeric Prostacyclin/Prostaglandin D2 Receptors |
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121 | (4) |
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| VI Eicosanoids and Neuroscience |
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An Unusual Nicotinic Acetylcholine Receptor Activates the 8-Lipoxygenase Pathway in Aplysia Neurons |
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125 | (4) |
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| VII Cardiovascular System |
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Neutrophil-Endothelial Cell Interaction: A Multidirectional Cross-Talk in Leukotriene Generation |
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129 | (6) |
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Cyclooxygenase in the Lamb Ductus Arteriosus: Developmental Changes and Upregulation |
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135 | (4) |
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Co-Localization of Prostacyclin (PG12)-Synthase and Caveolin-1 in Endothelial Cells Underscores New Roles of PGI2 In Angiogenesis |
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139 | (4) |
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| VIII Respiratory System |
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Leukotriene C4 Synthase Gene Polymorphism in Severe Asthma |
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143 | (6) |
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| IX Inflamation |
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Anti-Inflammatory Levels of Aspirin and Salicylate Inhibit Integrin-Dependent Human Neutrophil Aggregation and PMN Influx in COX2- and NFkB(P105)- Knockout Mice |
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149 | (6) |
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Antipyretic Action of Acetaminophen: Inhibition of the Cyclooxygenase Activity of Endothelial Cells Treated with IL-1 |
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155 | (4) |
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Leukotriene-Mediated Alteration of Endothelial Barrier Function |
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159 | (4) |
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GI and Cardiovascular Profiles of New NSAIDs: Selective COX-2 Inhibitors and NO-NSAIDs |
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163 | (8) |
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NO-Releasing NSAIDs Modulate Cytokine Secretion |
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171 | (8) |
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Potent Inhibitory Effects of a NO-NSAID (Flurbiprofen Nitroxybutylester) on Bone Resorption in Vitro and in Vivo |
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179 | (4) |
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| X Cancer |
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Lipid Peroxidation and Cyclooxygenase-2 Activity in Human Hepatocellular Carcinoma Cell Lines with and without Multiple Drug Resistance: Correlation with Cell Growth |
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183 | (4) |
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Pulmonary Prostacyclin Synthase Overexpression Improves Survival Following Butylated Hydroxytoluene Exposure |
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187 | (4) |
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| XI Isoprostanes |
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Reactive Products of the Isoprostane Pathway: Isoketals and Cyclopentenone A2/J2-Isoprostanes |
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191 | (6) |
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Increased Isoprostane 8-epi- PGF2A in Statin-Induced Myopathy |
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197 | (4) |
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| Index |
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