| Foreword |
|
V | (2) |
| Preface |
|
VII | (8) |
| List of Contributors |
|
XV | (4) |
| Opening Remarks |
|
XIX | |
| Part 1 Cytochrome Oxidases |
|
3 | (124) |
|
Structure and Possible Mechanism of Action of Cytochrome c Oxidase from the Soil Bacterium Paracoccus denitrificans |
|
|
3 | (10) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Crystal Structure and Reaction Mechanism of Bovine Heart Cytochrome c Oxidase |
|
|
13 | (11) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Cooperation of Two Quinone-Binding Sites in the Oxidation of Substrates by Cytochrome bo |
|
|
24 | (9) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Rapid Formation of a Semiquinone Species on Oxidation of Quinol by the Cytochrome bo(3) Oxidase from Escherichia coli |
|
|
33 | (7) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Coupling of Ion and Charge Movements: From Peroxidases to Protonmotive Oxidases |
|
|
40 | (7) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Ligand Dynamics in the Binuclear Site in Cytochrome Oxidase |
|
|
47 | (10) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Time-Resolved Resonance Raman Study of Dioxygen Reduction by Cytochrome c Oxidase |
|
|
57 | (15) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Human Cytochrome c Oxidase Analyzed with Cytoplasts |
|
|
72 | (12) |
|
|
|
|
|
|
Redox Behavior of Copper A in Cytochrome Oxidase in the Brain In Vivo: Its Clinical Significance |
|
|
84 | (14) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Crystallization of Bovine Heart Mitochondrial Cytochrome c Oxidase for X-Ray Diffraction at Atomic Resolution (2.8 A) |
|
|
98 | (4) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Mechanism of Dioxygen Reduction by Cytochrome c Oxidase as Studied by Time-Resolved Resonance Raman Spectroscopy |
|
|
102 | (4) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Coupling of Proton Transfer to Oxygen Chemistry in Cytochrome Oxidase: The Roles of Residues 167 and E243 |
|
|
106 | (6) |
|
|
|
|
|
|
|
|
|
|
|
Respiration of Helicobacter pylori, cb-Type Cytochrome c Oxidase, and Inhibition of NADH Oxidation by O(2) |
|
|
112 | (8) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
The Regulation by ATP of the Catalytic Activity and Molecular State of Thiobacillus novellus Cytochrome c Oxidase |
|
|
120 | (7) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Part 2 Cytochrome P-450 Monooxygenases |
|
127 | (136) |
|
Structure-Function Studies of P-450BM-3 |
|
|
127 | (12) |
|
|
|
|
|
|
|
|
|
|
|
Oxygen Binding to P-450(cam) Induces Conformational Changes of Putidaredoxin in the Ferrous P-450(cam)-Reduced Putidaredoxin Complex |
|
|
139 | (8) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Crystal Structure of Nitric Oxide Reductase Cytochrome P-450(nor) from Fusarium oxysporum |
|
|
147 | (9) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Analysis of NAD(P)H Binding Site of Cytochrome P-450(nor) |
|
|
156 | (5) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Substitutions of Artificial Amino Acids O-Methyl-Thr, O-Methyl-Asp, S-Methyl-Cys, and 3-Amino-Ala for Thr-252 of Cytochrome P-450(cam): Probing the Importance of the Hydroxyl Group of Thr-252 for Oxygen Activation |
|
|
161 | (5) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
From a Monooxygenase to an Oxidase: The P-450 BM3 Mutant T268A |
|
|
166 | (6) |
|
|
|
|
|
|
|
|
|
|
|
Thiolate Adducts of the Myoglobin Cavity Mutant H93G as Models for Cytochrome P-450 |
|
|
172 | (9) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Pronounced Effects of Axial Thiolate Ligand on Oxygen Activation by Iron Porphyrin |
|
|
181 | (8) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Superoxide via Peroxynitrite Blocks Prostacyclin Synthesis |
|
|
189 | (10) |
|
|
|
|
|
|
|
|
|
|
|
The N=N Bond Cleavage of Angeli's Salt Is Markedly Enhanced by Cytochrome P-450 1A2: Effects of Distal Amino Acid Mutations on the Formation of Nitric Oxide Complexes |
|
|
199 | (5) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Langmuir-Blodgett Films of Cytochrome P-450(scc): Molecular Organization and Thermostability |
|
|
204 | (10) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Kinetic Analysis of Successive Reactions Catalyzed by Cytochromes P-450(17XXX, lyase) and P-450(11Beta) |
|
|
214 | (7) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Changing Substrate Specificity and Product Pattern in Adrenal Cytochrome P-450-Dependent Steroid Hydroxylases |
|
|
221 | (10) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Inhibition Studies of Steroid Conversions Mediated by Human CYP11B1 and CYP11B2 Expressed in Cell Cultures |
|
|
231 | (6) |
|
|
|
|
|
|
|
|
|
|
|
Effects of ACTH and Angiotensin II on the Novel Cell Layer Without Corticosteroid-Synthesizing Activity in Rat Adrenal Cortex |
|
|
237 | (7) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Cell-Specific and Hormonally Regulated Gene Expression Directed by the CYP11B1 Gene Promoter in Rat Adrenal Cortex |
|
|
244 | (4) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Gene Organization and Genetic Defects of Bilirubin UDP-Glucuronosyltransferase |
|
|
248 | (4) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Imaging of Calcium Oscillations and Activity of Cytochrome P-450(scc) in Adrenocortical Cells |
|
|
252 | (11) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Part 3 Various Types of Oxidases and Oxygenases |
|
263 | (114) |
|
Fundamentally Divergent Strategies for Oxygen Activation by Fe(2+) and Fe(3+) Catecholic Dioxygenases |
|
|
263 | (13) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three-Dimensional Structure of an Extradiol-Type Catechol Ring Cleavage Dioxygenase BphC derived from Pseudomonas sp. strain KKS102: Structural Features Pertinent to Substrate Specificity and Reaction Mechanisms |
|
|
276 | (6) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Probing the Reaction Mechanism of Protocatechuate 3,4-Dioxygenase with X-Ray Crystallography |
|
|
282 | (7) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Nitric Oxide Synthases: Structure, Function, and Control |
|
|
289 | (9) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Electron Paramagnetic Resonance Studies on Substrate Binding to the NO Complex of Neuronal Nitric Oxide Synthase |
|
|
298 | (6) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Heme Oxygenase: A Central Enzyme of Oxygen-Dependent Heme Catabolism and Carbon Monoxide Synthesis |
|
|
304 | (11) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Heme Degradation Mechanism by Heme Oxygenase: Conversion of XXX-meso-Hydroxyheme to Verdoheme IX(XXX) |
|
|
315 | (7) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
A Spectroscopic Study on the Intermediates of Heme Degradation by Heme Oxygenase |
|
|
322 | (6) |
|
|
|
|
|
|
|
|
|
|
|
Expression of Heme Oxygenase and Inducible Nitric Oxide Synthase mRNA in a Human Glioblastoma Cell Line |
|
|
328 | (5) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
The Mechanism of Conversion of Xanthine Dehydrogenase to Xanthine Oxidase |
|
|
333 | (7) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Mechanism-Based Molecular Design of Peroxygenases |
|
|
340 | (14) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Catalytic Roles of the Distal Site Hydrogen Bond Network of Peroxidases |
|
|
354 | (5) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Catalytic Intermediates of Polyethylene-Glycolated Horseradish Peroxidase in Benzene |
|
|
359 | (4) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Formation of a Hydroperoxy Complex of Heme During the Reaction of Ferric Myoglobin with H(2)O(2) |
|
|
363 | (4) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Photooxidation in Ternary System Human Serum Albumin-Chlorin e(6)-Tryptophan |
|
|
367 | (10) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Part 4 Oxygen Sensing and Regulation of Blood Flow |
|
377 | (116) |
|
Tissue Oxygen Pressure and Oxygen Sensing by the Carotid Body |
|
|
377 | (11) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Molecular Mechanisms of Hypoxia-Induced Angiogenesis |
|
|
388 | (12) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Mechanisms of Pulmonary Vasodilatation and Ductus Arteriosus Constriction by Normoxia |
|
|
400 | (10) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Biological Impediment to Oxygen Sensing in Injured Pulmonary Microcirculation Exposed to a High-Oxygen Environment |
|
|
410 | (11) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Transcriptional Responses Mediated by Hypoxia-Inducible Factor 1 |
|
|
421 | (7) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Differences in Particle Size and Oxygen-Binding Affinity Between Cross-Linked Hemoglobin and Hemoglobin Vesicle |
|
|
428 | (6) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Activation of Gene Expression of Collagenase and ICAM-1 by UVA Radiation and by Exposure to Singlet Oxygen |
|
|
434 | (4) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Redox Regulation of the Nuclear Factor Kappa B (NF-kB) Signaling Pathway and Disease Control |
|
|
438 | (12) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Thioredoxin and Its Involvement in the Redox Regulation of Transcription Factors, NF-kB and AP-1 |
|
|
450 | (7) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Inhibition of Cytokines and ICAM-1 Induction in Rheumatoid Fibroblasts by anti-NF-kB Reagents |
|
|
457 | (7) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Detection of a Nuclear 60-kDa Protein Coimmunoprecipitated with Human Thioredoxin |
|
|
464 | (5) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Ito Cells: A Putative Cellular Component Responsible for Carbon Monoxide-Mediated Microvascular Relaxation in the Rat Liver |
|
|
469 | (4) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
K(+) Channels and the Normoxic Constriction of the Rabbit Ductus Arteriosus |
|
|
473 | (6) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Modulation of Adhesion Molecule Expression in Pulmonary Vascular Endothelium by Oxygen |
|
|
479 | (5) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Cross Talk Between Nitric Oxide and Cyclooxygenase Pathways in Glomerular Mesangial Cells |
|
|
484 | (9) |
|
|
|
|
|
|
|
|
|
|
| Part 5 Pathophysiology and Physiology of Gaseous Monoxides |
|
493 | (124) |
|
Pathophysiological Reactivities of Nitric Oxide |
|
|
493 | (12) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Defenses Against Peroxynitrite |
|
|
505 | (5) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Bioactive 6-Nitronorepinephrine Formation Requiring Nitric Oxide Synthase in Mammalian Brain |
|
|
510 | (8) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Role of Nitric Oxide in the Regulation of Cerebral Blood Flow in Conscious Rats |
|
|
518 | (19) |
|
|
|
|
|
|
|
|
|
|
|
Physiological Implication of Induction of Heme Oxygenase-1 Gene Expression |
|
|
537 | (7) |
|
|
|
|
|
|
Carbon Monoxide: Toxic Waste or Endogenous Modulator of Hepatobiliary Function? |
|
|
544 | (6) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Microspectrophotometry of Nitric Oxide-Dependent Changes in Hemoglobin in Single Red Blood Cells Incubated with Stimulated Macrophages |
|
|
550 | (7) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
An Antioxidant Role of Nitric Oxide in Modulation of Oxidative Stress in Human Placental Trophoblastic Cells |
|
|
557 | (5) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Liberation of Nitric Oxide from S-Nitrosothiols |
|
|
562 | (7) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Change of Nitric Oxide Concentration in Exhaled Gas After Lung Resection |
|
|
569 | (7) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Induction of NADPH Cytochrome P-450 Reductase in Kupffer Cells After Chronic Ethanol Consumption Associated with Increase of Superoxide Anion Formation |
|
|
576 | (4) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
In Vivo Measurement of Superoxide in the Cerebral Cortex Utilizing Cypridina luciferin analog (MCLA) Chemiluminescence |
|
|
580 | (5) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Effects of Zinc Protoporphyrin IX, a Heme Oxygenase Inhibitor, on Mitochondrial Membrane Potential in Rat Cultured Hepatocytes |
|
|
585 | (6) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Structure and Function of NO Reductase with Oxygen-Reducing Activity |
|
|
591 | (6) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Oxidative Modification of Apolipoprotein E3 and Its Biological Significance |
|
|
597 | (6) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Sequential Multistep Mechanisms for Leukocyte Adhesion: Applicable to Lung Microcirculation? |
|
|
603 | (6) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Role of Nitric Oxide in Autoregulation of Cerebral Blood Flow in the Rat |
|
|
609 | (8) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Key Word Index |
|
617 | |
