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Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor

Author(s): Yamamoto, Izuru; Casida, John E.
ISBN10: 443170213X
ISBN13: 9784431702139
Cover: Hardcover
 
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SummaryTable of Contents
The nicotinoids are the most important new class of pesticides, joining the organophosphorus compounds, methylcarbamates, and pyrethroids as the major insecticides. Recently, imidacloprid and related nicotinoids have begun replacing organophosphorus and methylcarbamate compounds as insecticides to control insect pests on major crops. Nicotinoids act on the nicotinic acetylcholine receptor, as does naturally occurring nicotine, but with remarkable effectiveness against insects while being safe for mammals; they are quickly degraded and do not persist in the environment. This volume describes the relationship of nicotinoids to botanical insecticidal alkaloids, their discovery and development as insecticides, and the prospects for their expanded use and for the development of resistance. This book is the first to provide concise, comprehensive information on nicotinoids, their chemistry, mode of action, metabolism, and application in agriculture.

Provides concise, comprehensive information on nicotinoids, their chemistry, mode of action, metabolism, and application in agriculture. Describes the relationship of nicotinoids to botanical insecticidal alkaloids, their discovery and development as insecticides, and the prospects for their expanded use. DLC: Nicotinoids.
Preface v
Part 1 Nicotine to Nicotinoids
Nicotine to Nicotinoids: 1962 to 1997
3(26)
I. Yamamoto
Nicotine and Other Insecticidal Alkaloids
29(42)
I. Ujvary
Discovery of the Nitromethylene Heterocycle Insecticides
71(20)
W.D. Kollmeyer
R.F. Flattum
J.P. Foster
J.E. Powell
M.E. Schroeder
S.B. Soloway
Discovery of Chloronicotinyl Insecticides
91(18)
S. Kagabu
Part 2 Synthetic Nicotinoid Insecticides
Chloronicotinyl Insecticides: A Success of the New Chemistry
109(18)
D. Wollweber
K. Tietjen
Discovery of a New Systemic Insecticide, Nitenpyram and Its Insecticidal Properties
127(22)
A. Akayama
I. Minamida
A Novel Insecticide, Acetamiprid
149(28)
T. Yamada
H. Takahashi
R. Hatano
CGA 29'343: A Novel, Broad-Spectrum Neonicotinoid Insecticide
177(36)
P. Maienfisch
F. Brandl
W. Kobel
A. Rindlisbacher
R. Senn
Part 3 Nicotinoid Insecticide Toxicology
Imidaclorid: Toxicology and Metabolism
213(10)
J. Thyssen
L. Machemer
The Action of Nicotine in the Mammalian Brain
223(14)
S. Fujii
E.C. Walcott
K. Sumikawa
Nicotine Analogs: Structure-Affinity Relationships for Central Nicotinic Acetylcholinergic Receptor Binding
237(16)
R.A. Glennon
M. Dukat
Managing Resistance to the Chloronicotinyl Insecticides-Rhetoric or Reality?
253(18)
M. Cahill
I. Denholm
Structure and Function of Insect Nicotinic Acetylcholine Receptors Studied with Nicotinoid Insecticide Affinity Probes
271(22)
M. Tomizawa
B. Latli
J.E. Casida
Index 293

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