Calcium Signaling, Second Edition

Calcium signals--rapid changes in calcium ion concentration--are carefully orchestrated by a suite of proteins that transport and bind to calcium ions inside cells. These signals influence virtually all aspects of animal development and physiology, from fertilization and cell differentiation to muscle contraction and nerve impulses. Aberrant calcium signaling is associated with various pathologies (e.g., cancer and neurodegeneration) as well as aging.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on all facets of calcium signaling. The contributors discuss the components and activities of the various calcium-sequestering organelles inside cells, the dynamic interactions that lead to spatiotemporally distinct signals in different circumstances, and the downstream effector mechanisms that translate the signals into biological outcomes. Recent advances in the field (e.g., structural insights into the functions of certain calcium channels) are emphasized throughout.

The authors also discuss normal and perturbed calcium signaling during fertilization, development, physiology, regeneration, aging, and disease. This volume is therefore an indispensable reference for biochemists, cell and developmental biologists, and physiologists seeking a comprehensive treatment of calcium signaling.

(preliminary)

Preface

Calcium Entry
Transient Receptor Potential (TRP) Channels and Calcium Signaling
Laura Vangeel and Thomas Voets
SOC
Richard Lewis
Agonist-induced calcium entry into cells
Indu Ambudkar

Calcium Release
IP3 Receptors
David L. Prole and Colin W. Taylor
NAADP Receptors
Antony Galione
Calcium leak channels
Martin Bootman & Geert Bultynck
Calcium microdomains
Anant Parekh

Calcium Stores and Calcium Transport Machines
The role of SERCA/SPCA/and PMCA in calcium signaling
Peter Vangheluwe

The roles of mitochondria in calcium signaling (molecules involved in mitochondrial calcium uptake)
Rosario Rizzuto

Mitochondrial calcium signaling (impact of mitochondrial signaling on calcium responses)
Genevieve Dupont and Laurent Combettes

Lysosomal calcium signaling
Emyr Lloyd-Evans
Cytosolic Ca2+ Buffers
Beate Schwaller
Organellar Calcium Handling in the Cellular Reticular Network
Wen-An Wang, Luis B. Agellon, and Marek Michalak

Downstream Effectors of Calcium
Interplay between calcium and cAMP signaling
Aldebaran Hofer
Calcium signaling via calcium/calmodulin-dependent kinase
John Kuriyan & Moitrayee Bhattacharyya
Calcium Sensors in Neuronal Function and Dysfunction
Robert D. Burgoyne, Nordine Helassa, Hannah V. McCue, and Lee P. Haynes
Identifying new substrates and functions for an old enzyme: calcineurin
Jagoree Roy and Martha S. Cyert

Physiological Processes Regulated by Calcium
Calcium and fertilization
Rafael Fissore
Role of two-pore channels in embryonic development and cellular differentiation
Sarah E. Webb, Jeffrey L. Kelu, & Andrew Miller
Functional consequences of calcium-dependent synapse-to-nucleus communication: focus on transcription-dependent metabolic plasticity
Anna M. Hagenston, Hilmar Bading, and Carlos Bas-Orth
Cardiac calcium signaling and regulation of gene transcription
Llewelyn Roderick
Astroglial Calcium Signaling in Ageing and Alzheimer's Disease
Alexei Verkhratsky
Calcium signaling in neuro-regulation
Jonathan Marchant

Calcium & Disease
Creating a New Cancer Therapeutic Agent by Targeting the Interaction Between Bcl-2 and IP3 Receptors
Clark W. Distelhorst and Martin D. Bootman
The Calcium Signaling Toolkit in Cancer: Remodeling and Targeting
Sarah J. Roberts-Thomson, Silke B. Chalmers, and Gregory R. Monteith
Calcium and neuropathology
Grace Stutzmann
Calcium signaling in tissue calcification
Diane Proudfoot
Calcium signaling in exocrine cells
Shmuel Muallem

Index