Cancer in the Spine

Distinguished physicians and researchers from prestigious Cancer Centers around the world offer their expertise in current and innovative management of cancer in the spine. These authors bring together the latest thinking from diverse fields of medicine to provide, in one volume, a guide to coordinated management of all aspects of spinal tumors covering chemo- and radiation therapy, pain management, diagnostic radiology, as well as reconstructive surgery and palliative care. Highlights include management of vertebral metastases, innovations in radiotherapy, treatment of pathological fractures, curative strategies for primary malignancies, as well as a guide to pain management and end-of-life care.

Preface	p. v
Contributors	p. ix
Cancer of the Spine: How Big Is the Problem?	p. 1
Metastatic Disease to the Musculoskeletal System	p. 7
The Pathophysiology of Spinal Metastases	p. 17
Tumor Behavior: Barriers to Growth and Spread	p. 25
Fundamentals of Cancer Treatment: Effects of Chemotherapy on Neoplastic Cells	p. 31
The Role of Surgical Therapy: Principles of Effective Surgical Treatment	p. 43
Presenting History and Common Symptoms of Spine Tumors	p. 49
Physical Examination: Signs of Pathology and the Spine Examination	p. 55
Imaging: Screening for Spinal Disease	p. 67
Imaging of the Spine	p. 73
Laboratory Studies and Diagnostic Work-Up of Bony Lesions in the Spine	p. 83
Principles of Medical Management	p. 93
Multiple Myeloma and Plasmacytoma	p. 101
Lymphoma	p. 107
Metastatic Breast Carcinoma	p. 117
Genitourinary Oncology: Prostate, Renal, and Bladder Cancer	p. 123
Spinal Metastases From Gastrointestinal Malignancies	p. 131
Lung Cancer	p. 141
Medical Management of Thyroid Cancer	p. 157
Carcinoma of the Unknown Primary
Primary Tumors of the Spine	p. 171
Common Radiotherapy Techniques for Spinal Tumors	p. 189
Spinal Radiotherapy for the Pediatric Patient: Indications, Special Technical Considerations, and Long-Term Consequences	p. 197
Conformal Radiotherapy for Spinal Lesions	p. 205
Photon- and Proton-Beam Radiotherapy in the Treatment of Spine Tumors	p. 211
Spinal Metastasis: Indications for Surgery	p. 219
Biopsy: Principles and Approaches	p. 227
Problem-Based Decision Making	p. 233
Spinal Cord and Nerve Root Decompression	p. 239
Metastatic Disease of the Cervical Spine	p. 247
Metastatic Disease of the Thoracolumbar Spine	p. 255
Complex Lumbosacral Resection and Reconstruction Procedure	p. 265
Neoplastic Disease of the Spinal Cord and the Spinal Canal	p. 279
Minimally Invasive Approaches to Spine Metastases: Endoscopic Surgery and Vertebral Augmentation	p. 285
Single-Stage Posterolateral Transpedicle Approach With Circumferential Decompression and Instrumentation for Spinal Metastases	p. 295
Primary Benign Spinal Tumors	p. 303
Surgical Treatment of Primary Malignant Tumors	p. 311
Complications of Surgical and Medical Care: Anticipation and Management	p. 323
Bracing for Patients With Spinal Tumors	p. 337
Rehabilitation in Patients With Tumors of the Spinal Column	p. 343
The Management of Pain in Spinal Malignancies	p. 349
Surveillance and Screening During Disease-Free Survival	p. 361
When is Enough, Enough?	p. 365
Index	p. 371
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