Cancer Therapies

, by Barton-Burke, Margaret; Wilkes, Gail M.

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ISBN: 9780763726829 | 0763726826
Cover: Paperback
Copyright: 3/27/2006

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This comprehensive reference is designed for the generalist nurse administering cancer therapy in non-oncology settings such as medical and surgical floors. Major topics include chemotherapy, biotherapy, moleculary targeted therapies, transplants, therapy in the non-malignant condition, a brief overview of drugs, safe administration, and competency issues and resources. There is no other reference currently available that specifically covers all of the Cancer Therapies in one resource and provides information on nursing management.

The Biological Basis of Cancer

(20)

Linda Workman

Introduction

(1)

Basic Genetics

(8)

DNA Structure

(2)

DNA Replication

(1)

Implications for Chemotherapy

(1)

Gene Function

(3)

Biology of Normal Cells

(6)

Features of Normal Cells

(3)

Apoptosis

(2)

Biology of Cancer Cells

(4)

Features of Cancer Cells

(1)

Malignant Transformation (Carcinogenesis)

(3)

Summary

(1)

References

(1)

Cancer Chemotherapy and Cell Cycle Kinetics

(18)

Margaret Barton-Burke

Gail M. Wilkes

History of Cancer Therapy

(2)

Advent of Cancer Chemotherapy

(1)

The Cell Cycle and Its Importance

(3)

Cell Cycle Phase-Specific Agents

(1)

Cell Cycle Phase-Nonspecific Agents

(1)

Chemotherapy and Cell Kinetics

(2)

Tumor Growth

(1)

Cell Kill Hypothesis

(1)

Relevance of Cytostatic Versus Cytotoxic Agents in Designing Chemotherapy Regimens

(1)

Classification of Antineoplastic Agents

(5)

Alkylating Agents

(2)

Antimetabolites

(1)

Antibiotics

(1)

Plant Alkaloids (Mitotic Inhibitors)

(1)

Hormones

(1)

Miscellaneous Agents

(1)

Camptothecins

(1)

Investigational Chemotherapeutic Agents

(1)

Rationale of Single-Agent Therapy Versus Combination Therapy

(2)

Mechanisms of Drug Resistance

(1)

Conclusion

(1)

References

(2)

Chemotherapy Drugs

(78)

Margaret Barton-Burke

Gail M. Wilkes

Acridinyl anisidide

(1)

Adrenocorticoids

(1)

Altretamine

(1)

Amifostine for injection

(1)

9-aminocamptothecin

(1)

Aminoglutethimide

(1)

Anastrozole

(1)

Androgens: testosterone propionate

(1)

Arsenic trioxide

(3)

Asparaginase

(1)

5-Azacytidine

(1)

Bicalutamide

(1)

Bleomycin sulfate

(1)

Busulfan

(1)

Busulfan injection

(1)

Capecitabine

(1)

Carboplatin

(1)

Carmustine

(1)

Chlorambucil

(1)

Cisplatin

(1)

Cladribine

(2)

Cyclophosphamide

(2)

Cytarabine, cytosine arabinoside

(1)

Cytarabine liposome injection

(1)

Dacarbazine

(1)

Dactinomycin

(1)

Daunorubicin citrate liposome injection

(1)

Daunorubicin hydrochloride

(1)

Decitabine

(1)

Dexrazoxane for injection

(1)

Docetaxel

(3)

Doxorubicin hydrochloride

(1)

Doxorubicin hydrochloride liposomal injection

(2)

Eniluracil

(1)

Epirubicin hydrochloride

(2)

Estramustine phosphate

(1)

Estrogens

(1)

Etoposide

(1)

Exemestane

(1)

Floxuridine

(1)

Fludarabine phosphate

(1)

5-Fluorouracil

(2)

Flutamide

(1)

Fulvestrant injection

(1)

Ftorafur (Tegafur) and Uracil

(1)

Gemcitabine

(1)

Goserelin acetate

(1)

Hydroxyurea

(1)

Idarubicin

(1)

Idoxifene

(1)

Ifosfamide

(1)

Irinotecan

(1)

Letrozole

(1)

Leuprolide acetate

(1)

Lomustine

(1)

Mechlorethamine hydrochloride

(1)

Megestrol acetate

(1)

Melphalan hydrochloride

(1)

Mercaptopurine

(1)

Methotrexate

(1)

Methyl-CCNU

(1)

Mitomycin

(1)

Mitoxantrone

(1)

Nilutamide

(1)

Oxaliplatin

(1)

Paclitaxel

100

(1)

Pegasparaginase

101

(1)

Pemetrexate

102

(1)

Pentostatin

103

(1)

Plicamycin

103

(1)

Procarbazine hydrochloride

104

(1)

Prolifeprosan 20 with carmustine (BCNU) implant

105

(1)

Raltitrexed

105

(1)

Streptozocin

106

(1)

Tamoxifen citrate

107

(1)

Temozolamide

108

(1)

Thioguanine

109

(1)

Thiotepa

109

(1)

Topotecan hydrochloride for injection

110

(1)

Toremifene citrate

111

(1)

Trimetrexate

112

(1)

Valrubicin

112

(1)

Vinblastine

113

(1)

Vincristine

114

(1)

Vinorelbine tartrate

114

(1)

References

115

(2)

Biologic Therapy for Cancer Treatment

117

(64)

Paula M. Muehlbauer

Introduction and Overview

117

(1)

Historical Perspective

117

(1)

Tumor Immunology

118

(2)

Tumor Escape Mechanisms

120

(1)

Interleukin-2 (IL-2)

120

(19)

Biologic Activity

120

(1)

Indications for the Use of IL-2

121

(1)

IL-2: Other Directions

121

(1)

Methods of Administration

122

(1)

Systemic Side Effects: Nursing and Medical Management

123

(7)

Subcutaneous IL-2

130

(1)

Clinical Pathways for Patients Receiving IL-2 Therapy

131

(1)

Eligibility for IL-2

131

(1)

Dose Modification for Il-2

131

(4)

Retreatment with IL-2

135

(3)

Discharge Teaching

138

(1)

Summary

138

(1)

The Interferons

139

(9)

Biologic Activity

140

(1)

IFN-α: Indications for Use

140

(5)

IFN-α: Side Effects and Medical Nursing Management

145

(3)

Supportive Care: Hematopoietic Growth Factors

148

(12)

Hematopoiesis

149

(5)

Hematopoiesis and HGFs

154

(1)

FDA-Approved Growth Factors in Clinical Use

154

(5)

Use of Growth Factors in the Elderly

159

(1)

Experimental Therapies

160

(12)

Cancer Vaccines

160

(10)

Adoptive Cellular Transfer

170

(2)

References

172

(9)

Molecular Targeted Therapy

181

(34)

Gail M. Wilkes

Introduction

181

(1)

Molecular Targets

182

(12)

Intracellular Malignant Flaws and Targets

194

(13)

Overexpression of Growth Factor Receptors and Mutations in Signaling Pathways

194

(5)

Angiogenesis

199

(1)

Proteasome Function

199

(7)

Apoptosis

206

(1)

Targeted Therapy: Malignant Lymphocytes

207

(4)

Nursing Implications in Caring for Patients Receiving Molecular Targeted Therapy

211

(1)

Future Horizons

211

(2)

The 21st Century in Cancer Care

213

(1)

References

213

(2)

Hematopoietic Stem-Cell Transplantation

215

(40)

Janice P. Maienza

Introduction

215

(4)

History

216

(1)

Rationale for Transplantation

217

(1)

Nursing Care

218

(1)

Pretransplantation Phase

219

(4)

Autologous HSCT

219

(1)

Allogeneic HSCT

219

(1)

Chronology of Transplantation

219

(1)

Autologous Pretransplantation Mobilization Phase

220

(1)

Allogeneic Pretransplantation Phase

221

(1)

Nursing Care during the Pretransplantation Phase

221

(2)

Transplantation Phase

223

(4)

Preparatory Regimens

223

(1)

Autologous Preparatory Transplantation Regimens

223

(1)

Allogeneic Transplantation Preparatory Regimens

224

(1)

Nursing Considerations during the Transplantation Phase

224

(2)

Transplantation Phase: Day 0

226

(1)

Autologous Day 0

226

(1)

Allogeneic Day 0

226

(1)

Nursing Care Day 0

226

(1)

Posttransplantation Phase

227

(24)

Engraftment Phase: Day 0 to Day 30

227

(17)

Postengraftment Period: Day 30 to Day 100

244

(4)

Postengraftment: Days 100+

248

(3)

Future Direction of HSCT

251

(1)

Glossary of Abbreviations

251

(1)

References

252

(3)

Cancer Therapy in Malignant and Nonmalignant Conditions: Safety and Administration Issues

255

(34)

Ann Marie B. Peterson

Margaret Barton-Burke

Introduction

255

(1)

The Need for an Infrastructure for Safe Administration of Cytotoxic Agents

256

(1)

Ordering Cancer Therapies Safely

257

(2)

Administering Cancer Therapies Safely

259

(1)

Using Cytotoxic Agents in Nonmalignant Conditions

260

(24)

Examples of Rheumatic Disorders Using Drug Therapies: Cytotoxic Agents, Biologic Response Modifiers, and Monoclonal Antibodies

262

(9)

Infrastructure for Administering Cytotoxic Agents or Biologic Response Modifiers in Nonmalignant Conditions

271

(12)

Oncology Nursing Society Guidelines and Relevance to Staff Caring for Patients with Nonmalignant Conditions

283

(1)

Similarities and Differences Between Drug and Administration in Malignant and Nonmalignant Conditions

283

(1)

Clinical Competency

284

(1)

Educational Program

285

(2)

Conclusion

287

(1)

References

288

(1)

Drug Interactions with Antineoplastic Medications

289

(22)

Michael Steinberg

Introduction

289

(1)

Pharmacokinetic Interactions

290

(8)

Absorption (Including Drug-Food) Interactions

290

(2)

Induction or Inhibition of Metabolism

292

(4)

Distribution and/or Elimination Interactions

296

(2)

Pharmacodynamic Interactions

298

(3)

Addictive Toxicity

298

(2)

Administration Sequence-Dependent Interactions

300

(1)

Therapeutic Interactions

301

(1)

Miscellaneous

301

(1)

Procarbazine

301

(1)

Alternative Therapy

302

(1)

Conclusion

302

(7)

References

309

(2)

Appendix I Standardized Nursing Care Plans

311

(40)

Index

351

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Cancer Therapies

Summary

Table of Contents

Supplemental Materials