Cancer Vaccines and Tumor Immunity

Cancer Vaccines and Tumor Immunity offers a review of the basic scientific discoveries that have moved forward into clinical trials. Presented in the context of real-world human research and experimentation, these major scientific advances demonstrate how our understanding of immune activation, T-regulatory cells, and autoimmunity will impact cancer vaccine design. The authors also explain how vaccination in the context of bone marrow transplantation will open new avenues for clinical study in the future.

Rimas J. Orentas, PhD, is Associate Professor in the Department of Pediatrics, Section of Hematology-Oncology, and holds joint appointments in the Departments of Medicine and Microbiology and Molecular Genetics at the Medical College of Wisconsin in Milwaukee, Wisconsin.

James W. Hodge, PhD, is a Senior Scientist in the Laboratory of Tumor Immunology and Biology at the National Cancer Institute in Bethesda, Maryland.

Bryon D. Johnson, PhD, is Associate Professor in the Department ofPediatrics, Section of Hematology-Oncology at the Medical College of Wisconsin in Milwaukee, Wisconsin.

Contributors	p. ix
Foreword: Cancer Vaccines and Cancer Immunotherapy: A New Paradigm	p. xiii
Introduction
Cancer Vaccines: Progress and Promise	p. 3
Adjuvant Therapy: Enhancing the Endogenous Immune Response
Fully Synthetic Carboyhydrate-Based Antitumor Vaccines	p. 15
Bacillus Calmette-Guerin Immunotherapy of Genitourinary Cancer	p. 29
Stimulation of Toll-Like Receptor 9 for Enhancing Vaccination	p. 43
Antigen-Specific Therapy: Novel Presentation of Peptide and Protein Antigens
Polyepitope Vaccines	p. 69
Antigen-Specific Cancer Immunotherapy: HPV-Associated Cervical Cancer as a Model System	p. 79
Poxviral Vectors for Cancer Vaccines: State of the Art	p. 95
Immunotherapeutic Strategies Against Cancer Using Listeria monocytogenes as a Vector for Tumor Antigens	p. 113
Coupling Innate and Adaptive Immunity with Yeast-Based Cancer Immunotherapy	p. 131
Cell-Based Therapy: Using Cancer Cells as a Means to Induce Specific Tumor Immunity
Allogeneic Whole-Cell Vaccines	p. 153
Jump-Starting Tumor Immunity with Breast Cancer Therapeutics	p. 169
T-Regulatory Cell Manipulation in Tumor Immunotherapy	p. 189
Tumor Vaccination After Autologous HSCT: What Has Been Learned from Experimental Models	p. 205
Vaccines in the Setting of Hematopoietic Stem Cell Transplantation	p. 217
Intratumor Generation of Vigorous Antitumor Immune Responses	p. 229
Cancer Immunotherapy: Untapping the Potential of Costimulatory Molecules Beyond CTLA-4	p. 243
Defining Effective Clinical Responses
Advances in Immune Monitoring Strategies for Cancer Vaccines and Immunotherapy	p. 271
Immune Evaluation of Cancer Vaccines	p. 291
Index	p. 309
Table of Contents provided by Ingram. All Rights Reserved.

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Cancer Vaccines and Tumor Immunity

Summary

Author Biography

Table of Contents

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