Carbohydrate Chemistry
, by Rauter, Amelia Pilar; Lindhorst, Thisbe K.; Alamae, Tiina; Andrade, Marta M.; Arda, AnaNote: Supplemental materials are not guaranteed with Rental or Used book purchases.
- ISBN: 9781849734394 | 1849734399
- Cover: Hardcover
- Copyright: 8/23/2012
A review of coverage relevant to the chemistry of monosaccharides and oligosaccharides in a given year.
Preface | p. vii |
Applications of glycobiology: biological and immunological effects of a chemically modified amylose-derivative | p. 1 |
Introduction | p. 1 |
Historical breakthroughs and examples | p. 2 |
Polysaccharides and derivatives | p. 5 |
An historical finding in virology? | p. 5 |
COAM does not induce interferon | p. 6 |
COAM is an immunomodulator | p. 7 |
Therapeutic implications for acute and chronic inflammation and cancer | p. 8 |
Conclusions and future perspectives | p. 9 |
Abbreviations | p. 10 |
Acknowledgements | p. 10 |
References | p. 10 |
Lipopolysaccharide structure and biological activity from the cystic fibrosis pathogens Burkholderia cepacia complex | p. 13 |
Introduction | p. 13 |
Basic Lipopolysaccharide structure | p. 16 |
The detailed chemical structure of the P. aeruginosa LPS | p. 20 |
Burkholderia cepacia complex and Cystic Fibrosis | p. 23 |
General structural features of the core region of BCC LPS | p. 28 |
O-chain of BCC LPS | p. 30 |
Conclusion | p. 33 |
Acknowledegments | p. 34 |
References | p. 34 |
Synthesis of bacterial carbohydrate surface structures containing Kdo and glycero-D-manno-heptose linkages | p. 40 |
Introduction | p. 40 |
Kdo-containing structures and Kdo donors | p. 40 |
Glycero-D-manno-heptose-containing structures | p. 48 |
References | p. 59 |
Synthetic glycopeptides in vaccine development and antibody epitope mapping | p. 61 |
Introduction | p. 61 |
Protein conjugate vaccines | p. 62 |
Build-in adjuvant vaccines | p. 65 |
Dendrimer vaccines | p. 68 |
Antibody epitope mapping | p. 69 |
Conclusions | p. 72 |
References | p. 73 |
Posttranslational sialylation and its impact on leukocyte recruitment during inflammation | p. 75 |
Leukocyte recruitment cascade | p. 75 |
Posttranslational modifications | p. 78 |
Sialic acids and sialyltransferases (ST) | p. 82 |
Sialylation-dependent functions of signalling and adhesion relevant molecules | p. 88 |
Conclusion and outlook | p. 91 |
References | p. 91 |
Glycoengineering of protein-based therapeutics | p. 94 |
Introduction | p. 94 |
Impact of N-glycosylation on therapeutic proteins | p. 95 |
Glycosylation optimization | p. 105 |
Conclusions | p. 113 |
References | p. 115 |
Congenital Disorders of Glycosylation (CDG): from glycoproteins to patient care | p. 124 |
Introduction | p. 124 |
Basic principles of protein glycosylation | p. 124 |
Congenital disorders of glycosylation (CDG) | p. 128 |
Concluding remarks and future perspectives: CDG as a challenge for glycobiomedicine in the next decade! | p. 144 |
Highlights | p. 145 |
Further information | p. 146 |
Abbreviations | p. 146 |
Acknowledgements | p. 147 |
References | p. 147 |
Bladder cancer-glycosylation insights | p. 156 |
Introduction | p. 156 |
Bladder cancer: epidemiology and current treatment | p. 157 |
General aspects of glycosylation | p. 158 |
Final considerations/conclusions | p. 168 |
Abbreviations | p. 169 |
References | p. 169 |
Levansucrases of Pseudomonas bacteria: novel approaches for protein expression, assay of enzymes, fructooligosaccharides and heterooligofructans | p. 176 |
Levansucrase genes and proteins | p. 176 |
Heterologous expression of levansucrases from Pseudomonas syringae pv. tomato with two different expression systems | p. 177 |
Biochemical properties of the levansucrases: substrate specificity and kinetic parameters | p. 178 |
Predicted catalytic triad residues and 3D structures of Lsc1, Lsc2, Lsc3 and LscA proteins | p. 179 |
Lsc2, Lsc3 and LscA produce not only levan, but also FOS that can be detected by a novel mass spectrometric method | p. 180 |
Isolation and novel screening methods for levansucrase mutants | p. 186 |
Concluding remarks and future perspectives | p. 189 |
Acknowledgments | p. 190 |
References | p. 190 |
Recent advances on the application of NMR methods to study the conformation and recognition properties of carbohydrates | |
Introduction | p. 192 |
The access to new NMR parameters and methodological developments | p. 192 |
Applications. Saccharides in solution | p. 194 |
Applications. The interaction of saccharides with other natural and synthetic molecules | p. 202 |
Acknowledgments | p. 210 |
References | p. 210 |
Glycosidase inhibitors: versatile tools in glycobiology | p. 215 |
Introduction | p. 215 |
Polyhydroxylated pyrrolidines | p. 216 |
Six-membered ring-based imino sugars | p. 219 |
Azepanes and azetidines | p. 226 |
Bicyclic imino sugars | p. 231 |
Thio, seleno and carbasugars as glycosidase inhibitors | p. 245 |
Miscellaneous | p. 250 |
Pharmacological activities of imino sugars | p. 251 |
Concluding remarks | p. 256 |
Acknowledgements | p. 256 |
References | p. 256 |
An overview of key routes for the transformation of sugars into carbasugars and related compounds | p. 263 |
Introduction | p. 263 |
Strategies for the synthesis of carbasugars and pseudo-carbasugars | p. 265 |
Acknowledgements | p. 296 |
References | p. 297 |
Multivalent glyeoconjugates in medicinal chemistry | p. 303 |
Introduction | p. 303 |
Glycoclusters with a flexible core | p. 303 |
Glycoclusters with a rigid core | p. 308 |
Multivalent glycopeptides in immunotherapy | p. 313 |
Glycoconjugates on tubular scaffolds | p. 318 |
Glycodendrimer chips | p. 318 |
Glyconanoparticles | p. 320 |
Conclusions | p. 331 |
Acknowledgements | p. 331 |
References | p. 331 |
Glycotransporters for gene delivery | p. 338 |
Introduction | p. 338 |
Carbohydrate-grafted cationic polymers and lipids | p. 341 |
De novo designed carbohydrate-based polymers | p. 346 |
Preorganized glycomaterials for gene delivery | p. 354 |
Outlook and perspectives | p. 368 |
Acknowledegments | p. 368 |
References | p. 369 |
Furanose-based templates in the chemoselective generation of molecular diversity | p. 376 |
Introduction | p. 376 |
Design and synthesis of functionalized furanose-based precursors | p. 377 |
Reactivity of functionalized furanose-based precursor 4a | p. 380 |
Reactivity of the alkenyl halide moiety in functionalized furanose-based precursors 4b,c | p. 387 |
Three components assembly of functionalized furanose derivatives 4b,c | p. 388 |
Generation of furanosidic libraries possessing' three ûor more - sites for molecular diversity | p. 391 |
Conclusions | p. 392 |
Abbreviations | p. 393 |
Acknowledgements | p. 393 |
References | p. 393 |
Synthesis of carbohydrate-based artificial siderophores and their biological applications | p. 398 |
Introduction | p. 398 |
Artificial siderophores - background | p. 400 |
Synthesis of Carbohydrate-based artificial siderophores | p. 402 |
Study of siderophore activity | p. 407 |
Conclusions and perspectives | p. 412 |
References | p. 414 |
Smart biomaterials: the contribution of glycoscience | p. 416 |
Introduction: biomaterials and tissue engineering | p. 416 |
Glycoscience for biomaterials design | p. 424 |
Conclusions | p. 440 |
References | p. 440 |
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