Carotenoids in Health and Disease

This stimulating reference studies the role of carotenoids in the prevention of chronic disease and reviews breakthrough studies from more than 40 field authorities on the latest biochemical research, as well as carotenoid absorption, transport, metabolism, and bioconversion to vitamin A.

Series Introduction

iii

Lester Packer

Enrique Cadenas

Preface

vii

Contributors

xiii

Basic Carotenoid Chemistry

1

(30)

Synnøve Liaaen-Jensen

Carotenoids and Radicals: Interactions with Other Nutrients

31

(22)

Ann Cantrell

T. George Truscott

Noninvasive Assessment of Carotenoids in the Human Eye and Skin

53

(32)

Paul S. Bernstein

Werner Gellermann

Methodology for Assessment of Carotenoid Levels in Blood and Plasma Fractions

85

(20)

Mario G. Ferruzzi

Steven J. Schwartz

Carotenoid Antioxidant Activity

105

(22)

Andrew J. Young

Denise M. Phillip

Gordon M. Lowe

Evidence for Pro-Oxidant Effects of Carotenoids In Vitro and In Vivo: Implications in Health and Disease

127

(24)

Paola Palozza

Carotenoid Orientation: Role in Membrane Stabilization

151

(14)

Wieslaw I. Gruszecki

Anticancer Activity of Carotenoids: From Human Studies to Cellular Processes and Gene Regulation

165

(32)

Yoav Sharoni

Wilhelm Stahl

Michael Danilenko

Joseph Levy

Induction of Cytochrome P450 Enzymes by Carotenoids

197

(12)

Nora O'Brien

Tom O'Connor

Impact of Food Processing on Content and Bioavailability of Carotenoids

209

(20)

Amy C. Boileau

John W. Erdman, Jr.

Transport, Uptake, and Target Tissue Storage of Carotenoids

229

(50)

Harold C. Furr

Richard M. Clark

Bioequivalence of Provitamin A Carotenoids

279

(16)

Guangwen Tang

Robert M. Russell

Bioconversion of Provitamin A Carotenoids

295

(18)

Arun B. Barua

Carotenoid Oxidative/Degradative Products and Their Biological Activity

313

(24)

Xiang-Dong Wang

Conversion of Carotenoids to Vitamin A: New Insights on the Molecular Level

337

(20)

Johannes von Lintig

Enzymatic Versus Chemical Cleavage of Carotenoids: Supramolecular Enzyme Mimics for β-Carotene 15,15'-Monooxygenase

357

(16)

Wolf-D. Woggon

Mrinal K. Kundu

Relationship of Carotenoids to Cancer

373

(36)

Cheryl L. Rock

Lycopene and Carcinogenesis

409

(18)

Eileen Ang

Elizabeth C. Miller

Steven K. Clinton

Carotenoids and Eye Disease: Epidemiological Evidence

427

(18)

Julie A. Mares

Mechanistic Evidence for Eye Diseases and Carotenoids

445

(28)

John T. Landrum

Richard A. Bone

Heart and Vascular Diseases

473

(18)

Howard D. Sesso

J. Michael Gaziano

Carotenoids in Systemic Protection Against Sunburn

491

(12)

Wilhelm Stahl

Helmut Sies

Carotenoids and Immune Responses

503

(16)

David A. Hughes

Therapeutic Uses of Carotenoids in Skin Photosensitivity Diseases

519

(12)

Micheline M. Mathews-Roth

Potential Adverse Effects of β-Carotene Supplementation in Cigarette Smokers and Heavier Drinkers

531

(16)

Demetrius Albanes

Margaret E. Wright

Carotenoids: Looking Forward

547

(6)

Norman I. Krinsky

Susan T. Mayne

Helmut Sies

Index

553

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Carotenoids in Health and Disease

Summary

Table of Contents

Supplemental Materials