Chemistry and the Sense of Smell

CHARLES S. SELL, PHD, has recently retired from Givaudan after thirty-six years in the fragrance industry. His work has covered all aspects of synthetic organic chemistry as applied to the fragrance industry, from discovery of novel materials through process R&D to improvement of established chemical manufacturing processes. His interest in the design of novel fragrance ingredients, coupled with a long-standing interest in the chemistry of living organisms, led to a deepened investigation into olfaction.

Acknowledgments ix

Introduction 1

1 Why Do We Have a Sense of Smell? 4

2 The Mechanism of Olfaction 32

3 Analysis and Characterisation of Odour 188

4 The Sense of Smell in Our Lives 209

5 The Scents of Nature 237

6 Manufacture of Fragrance Ingredients 296

7 The Design of New Fragrance Ingredients 357

8 The Relationship Between Molecular Structure and Odour 388

9 Intellectual Challenges in Fragrance Chemistry and the Future 420

Glossary 428

Index 437

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