Citrus Limonoids Functional Chemicals in

This book focuses on phytonutrients, specifically, the highly oxygenated triterpenoids called limonoids that occur primarily in the genus Citra and other closely related genera. It reviews the history of chemical research on limonoids and discusses their biological benefits, including cancer prevention in humans and antifeedant activity in agricultural pests.

Preface

xi

Citrus Limonoid Research: An Overview

1

(8)

Shin Hasegawa

Mark A. Berhow

Gary D. Manners

Biochemistry of Limonoids in Citrus

9

(22)

Shin Hasegawa

Analysis of Limonoids by Thin-Layer Chromatography

31

(9)

Shin Hasegawa

Mark A. Berhow

LC-MS and NMR Techniques for the Analysis and Characterization of Citrus Limonoids

40

(20)

Gary D. Manners

Shin Hasegawa

Raymond D. Bennett

Rosalind Y. Wong

Analysis of Limonin and Flavonoids in Citrus Juices and Byproduct Extract by Direct Injection and In-Line Sample Clean-Up

60

(13)

W. W. Widmer

C. A. Haun

Quantification of Limonin and Limonoate A-Ring Monolactone During Growth and Development of Citrus Fruit and Vegetative Tissues by Radioimmunoassay

73

(23)

C. A. McIntosh

Extraction and Recovery of Limonoids with the Supercritical Carbon Dioxide Micro-Bubble Method

96

(11)

Masaki M. Shimoda

Y. Osajima

Nobuya Inaba

Shigeru Ayanoe

Yoshihiko Ozaki

Shin Hasegawa

Limonoid Glucosides of Satsuma Mandarin (Citrus unshiu Marcov.) and Its Processing Products

107

(13)

Yoshihiko Ozaki

Masaki Miyake

Nobuya Inaba

Shigeru Anayo

Yasushi Ifuku

Shin Hasegawa

Commercial Debittering Processes to Upgrade Quality of Citrus Juice Products

120

(12)

Philip E. Shaw

Leigh Baines

Bradford A. Milnes

Gilad Agmon

Citrus Limonoids: Increasing Importance as Anticancer Agents

132

(13)

E. G. Miller

S. E. Taylor

C. W. Berry

J. A. Zimmerman

Shin Hasegawa

Citrus Limonoids Obacunone and Limonin Inhibit the Development of a Precursor Lesion, Aberrant Crypt Foci, for Colon Cancer in Rats

145

(19)

Takuji Tanaka

Hiroyuki Kohno

Kunihiro Kawabata

Shiro Honjo

Masaki Miyake

Keiji Wada

Inhibition of Human Breast Cancer Cells by Citrus Limonoids

164

(11)

N. Guthrie

K. Morley

Shin Hasegawa

Gary D. Manners

T. Vandenberg

Regulation of Apo B Production in HepG2 Cells by Citrus Limonoids

175

(10)

Elzbieta M. Kurowska

Carina Banh

Shin Hasegawa

Gary D. Manners

Limonin and Nomilin Inhibitory Effects on Chemical-Induced Tumorigenesis

185

(16)

Luke K. T. Lam

Shin Hasegawa

Carl Bergstrom

Sylvia H. Lam

Patrick Kenney

Prospects for Citrus Limonoids in Insect Pest Management

201

(11)

A. Randall Alford

Kathleen D. Murray

Limonoids and the Chemotaxonomy of Citrus and the Rutaceae Family

212

(18)

Mark A. Berhow

Shin Hasegawa

Karen Kwan

Raymond D. Bennett

Genetic Evaluation and Modification of the Accumulation of Limonoids in Citrus

230

(8)

M. Omura

M. Kita

T. Endo-Inagaki

T. Moriguchi

R. Matsumoto

C. Suhayda

Shin Hasegawa

Author Index

238

(1)

Subject Index

239

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Citrus Limonoids Functional Chemicals in Agriculture and Food

Summary

Table of Contents

Supplemental Materials