Coenzyme Q: Molecular Mechanisms in Health

Since its discovery in 1957, Coenzyme Q has piqued the interest of scientists from a wide range of disciplines because of its vitamin-like behavior and its interactions with antioxidant vitamins E and C. Coenzyme Q: Molecular Mechanisms in Health and Disease is a comprehensive treatise on this often-studied enzyme.Catalog Copy

PART 1 MOLECULAR MECHANISMS OF COENZYME Q

Section 1A Chemical and Physical Properties

Mobility of Coenzyme Q in Membranes

5

(24)

Giorgio Lenaz

Topography of Coenzyme Q in Membranes

29

(14)

Peter J. Quinn

Free Radical Chemistry of Coenzyme Q

43

(22)

Kazuo Mukai

Section 1B Biochemical Mechanisms in Electron Transport in Mitochondria and Extramitochondrial Locations

Coenzyme Q Oxidation Reduction Reactions in Mitochondrial Electron Transport

65

(18)

P. Leslie Dutton

Tomoko Ohnishi

Elisabeth Darrouzet

Mary A. Leonard

R. Eryl Sharp

Brian R. Gibney

Fevzi Daldal

Christopher C. Moser

Extramitochondrial Functions of Coenzyme Q

83

(16)

Jose Manuel Villalba

Guillermo Lopez-Lluch

Carlos Santos-Ocana

Juan Carlos Rodriguez-Aguilera

Placido Navas

The Role of Coenzyme Q In Lysomes

99

(10)

Hans Nohl

Lars Gille

Section 1C Antioxidant Mechanisms

Antioxidant Dynamics of Coenzyme Q in Membranes

109

(10)

Etsuo Niki

Independent and Concerted Antioxidant Functions of Coenzyme Q

119

(12)

Valerian E. Kagan

James P. Fabisiak

Yulia Y. Tyurina

Mechanisms of Antioxidant Action of Ubiquinol-10 for Low-Density Lipoprotein

131

(20)

Shane R. Thomas

Roland Stocker

Biochemical and Pharmacological Properties of Coenzyme Q Analogs

151

(12)

Alvaro Mordente

Elisabetta Meucci

Giuseppe Ettore Martorana

Giorgio Minotti

Bruno Giardina

Section 1D Prooxidant Mechanisms

Coenzyme Q as a Generator of Reactive Oxygen Metabolites

163

(22)

Hans Nohl

Lars Gille

Andrey Kozlov

Katrin Staniek

PART 2 NUTRITIONAL ASPECTS OF COENZYME Q

Section 2A Biosynthesis and Nutritional Sources

Genetic Analysis of Coenzyme Q Biosynthesis

185

(24)

Tanya Jonassen

Catherine F. Clarke

Dietary Intake and Absorption of Coenzyme Q

209

(10)

Christine Weber

Section 2B Dietary Supplementation and Plasma/Tissue Concentrations

Protection Against Oxidative Stress by Chronic Administration of Coenzyme Q

219

(8)

Gian Paolo Littarru

Maurizio Battino

Analysis of Coenzyme Q in Biological Samples

227

(24)

Guy Rousseau

Christine Des Rosiers

PART 3 HEALTH EFFECTS OF COENZYME Q

Section 3A Coenzyme Q Status and Oxidative Stress in Vivo

Plasma Ubiquinol-10 as a Marker for Disease

251

(10)

Anatol Kontush

Redox Status of Plasma Coenzyme Q as an Indicator of Oxidative Stress

261

(10)

Yorihiro Yamamoto

Satoshi Yamashita

Section 3B Cardiovascular Pathology

Coenzyme Q as a Marker of Oxidative Stress in Coronary Artery Disease

271

(6)

Johan Bernard Ubbink

Role of Coenzyme Q10 in Myocardial Tolerance to Ischemia and Reperfusion

277

(8)

Hajime Otani

Dipak K. Das

The Role of Coenzyme Q in Controlling the Endothelial Function and Arterial Tone

285

(8)

Kimmo Lonnrot

Janne Leinonen

Hannu Alho

Implication of Coenzyme Q Depletion in Heart Transplantation

293

(14)

Anna Gvozdjakova

Jarmila Kucharska

Section 3C Liver Injury

A Role for Coenzyme Q in Alcoholic Liver Disease?

307

(10)

Simon Eaton

Christopher O. Record

Kim Bartlett

Ubiquinone, Oxidative Stress, and Liver Carcinogenesis

317

(16)

Per Stal

Jerker M. Olsson

Section 3D Physical Performance/Training

Effects of Ubiquinone-10 Supplementation on Physical Performance in Humans

333

(12)

Christer Malm

Michael Svensson

Coenzyme Q and Antioxidant Potential in Athletes

345

(12)

Tommi Vasankari

Markku Ahotupa

Exercise-Induced Oxidative Stress and Coenzyme Q

357

(14)

Jerzy Faff

Section 3E Aging

Coenzyme Q Supplementation and Longevity

371

Hannu Alho

Kimmo Lonnrot

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Coenzyme Q: Molecular Mechanisms in Health and Disease

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Table of Contents

Supplemental Materials