Color Atlas of Clinical Hematology Molecular and Cellular Basis of Disease

Provides coverage of the pathogenesis, clinical, morphologic, molecular and investigational aspects of a full range of blood disorders seen in daily practice

The revised fifth edition of this renowned atlas presents readers with a comprehensive, visual guide to clinical hematology, featuring 2700 full-color photographs and figures depicting the spectrum of hematological diseases. Ranging from photographs of the clinical manifestations and key microscopic findings to diagrams of the molecular aspects of these diseases, the book provides up-to-date information of the blood diseases that clinicians encounter every day.

Color Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease offers the reader an understanding of normal cell machinery, and of the molecular basis for such processes as DNA and cell replication, RNA species, trafficking and splicing, protein synthesis, transcription factors, growth factor signal transduction, epigenetics, cell differentiation, autophagy, and apoptosis. The text goes on to explore how these processes are disturbed in the various diseases of the bone marrow, blood, and lymphoid systems.

• Helps solve difficult diagnostic challenges and covers complex principles using highly illustrative, full-color images
• Explores all aspects of benign and malignant hematology, including blood transfusion and coagulation with extensive coverage of the pathogenesis of common clinical entities
• Provides a quick and easy reference of key diagnostic issues in a comprehensive yet concise format
• Includes and illustrates the WHO Classification of Hematologic Malignancies
• Illustrates the new knowledge of the molecular basis of inherited and acquired blood diseases

Color Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease is the must-have resource for both trainee and practising hematologists, and for every department of hematology.

"Substantially updated and now multi-authored so that all aspects of haematology are equally covered, including the newest developments in molecular biology and genomic sequencing"

"There is a surplus of invention in communicating complex problems here and an admirable effort to keep the reader totally up-to-date"

A. Victor Hoffbrand, MA, DM, FRCP, FRCPath, DSc, FMed Sci, is Emeritus Professor of Haematology at University College, London, UK.

Paresh Vyas, FRCP, FRCPath, DPhil, is Professor of Haematology, Director of Oxford Centre for Haematology, Honorary Consultant Haematologist and Group Leader, MRC Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

Elías Campo, MD, is Senior Consultant and Research Director, Hospital Clinic of Barcelona, and Professor of Anatomical Pathology at University of Barcelona, Faculty of Medicine, Barcelona, Spain.

Torsten Haferlach, MD, MLL Munich Leukemia Laboratory, Munich, Germany.

Keith Gomez, MBBS, MRCP, FRCPath, PhD, is Consultant Haematologist at Royal Free London NHS Foundation Trust, UK.

Preface xxx

1 Molecular Biology of the Cell

2 Hematopoiesis

3 Growth Factor Signaling

4 Erythropoiesis and Examination of the Peripheral Blood and Bone Marrow

5 Hypochromic Anemias

6 The Porphyrias and Iron Overload

7 Megaloblastic Anemias

8 Hemolytic Anemias

9 Genetic Disorders of Hemoglobin

10 Benign Disorders of Phagocytes

11 Benign Disorders of Lymphocytes and Plasma Cells

12 Aplastic and Dyserythropoietic Anemias

13 The Hematologic Neoplasms: Laboratory Techniques and Acute Myeloid Leukemia

14 Acute Lymphoblastic Leukemia

15 Myelodysplastic Syndromes

16 Myeloproliferative Neoplasms

17 Mastocytosis, Myeloid/Lymphoid Neoplasms with Eosinophilia and Specific Cytogenetic Rearrangements, Myelodysplastic/Myeloproliferative Neoplasms

18 Chronic Lymphocytic Leukemia and Other Mature B- and T/Nk-Cell Leukemias

19 Small B-Cell Lymphomas

20 Aggressive Mature B-Cell Neoplasms

21 Myeloma and Related Neoplasms

22 Peripheral T- and NK-Cell Neoplasms

23 Hodgkin Lymphoma

24 Histiocytic Disorders

25 Stem Cell Transplantation

26 Normal Hemostasis, Platelet Production and Function

27 Vascular and Platelet Bleeding Disorders

28 Inherited and Acquired Coagulation Disorders

29 Thrombosis and Antithrombotic Therapy

30 Hematologic Aspects of Systemic Diseases

31 Parasitic Disorders

32 Blood Transfusion

Appendix 1 2016 World Health Organization Classification of Lymphoid and Myeloid Neoplasms

Index xxx

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