Combining Human Genetics and Causal Inference to Understand Human Disease and Development

(preliminary)

Preface

New Opportunities
George Davey Smith, Rebecca Richmond, John-Baptiste Pingault

Concepts

The Meaning of "Cause" in Genetics
Kate E. Lynch

Family-Based Study Designs

Twins and Causal Inference: Leveraging Nature's Experiment
Tom A. McAdams, Fruhling V. Rijsdijk, Helena M.S. Zavos, and Jean-Baptiste Pingault
Family-Based Designs that Disentangle Inherited Factors from Pre- and Post-Natal Environmental Exposures: In Vitro Fertilization, Discordant Sibling Pairs, Maternal Versus Paternal Comparisons and Adoption Designs
Anita Thapar and Frances Rice

Population-Based Genetic Designs

Mendelian Randomization: Concepts and Scope
Rebecca C. Richmond and George Smith Davey
Polygenic Mendelian Randomization
Frank Dudbridge
Multivariable Mendelian Randomization and Mediation
Eleanor Sanderson

Integration of Methods and Data

Integrating Family-Based and Mendelian Randomization Designs
Liang-Dar Hwang, Neil M. Davies, Nicole M. Warrington, and David M. Evans
Causal Inference Methods to Integrate Omics and Complex Traits
Eleonora Porcu, Jennifer Sjaarda, Kaido Lepik, Cristian Carmeli, Liza Darrous, Jonathan Sulc, Ninon Mounier, and Zolt?n Kutalik
Computational Tools for Causal Inference in Genetics
Tom G. Richardson, Jie Zheng, and Tom R. Gaunt

Genetics and Causation in Practice

Using Mendelian Randomization to Improve the Design of Randomized Trials
Brian A Ference, Michael V Holmes, George Davey Smith
Triangulating Evidence Through the Inclusion of Genetically Informed Designs
Marcus R Munaf?, Julian PT Higgins, George Davey Smith

Index