Diseases of the Liver and Biliary System in Children

This market-leading book, with comprehensive coverage of the entire spectrum of liver disease in children, returns with 12 brand new chapters covering key areas in liver transplantation, viral hepatitis, and liver disease in infancy.

Authored by the world’s leading hepatologists and pediatricians and expertly edited by Deirdre Kelly, it covers the entire topic from pathology to diagnosis and clinical management, and in all stages of childhood from the unborn baby through to infancy, and from childhood to the transition into adolescence. Hepatologists, pediatricians and gastroenterologists of all levels will find it an essential tool to consult time and time again

Prof Deirdre Kelly is one of the world's leading pediatric hepatologists, and was responsible for helping create the Paediatric Liver Unit at Birmingham Children's Hospital, a leading national and international institution for children with liver disease and undergoing liver transplantation.
She runs an active research programme focussing on viral hepatitis in children, molecular genetics of inherited liver disease, and quality/outcome of life following liver/intestinal transplantation.
She's a former President of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN), the British Society for Paediatric Gastroenterology, Hepatology and Nutrition and the International Paediatric Transplant Association. She has been on the editorial boards of the Journal of Liver Transplantation and Surgery, Pediatric Transplantation and Alimentary Pharmacology & Therapeutics, and has had 250 papers published, as well as 7 books and 26 book chapters.

Contributors, vii

Foreword to the First Edition, x

Preface, xi

Acknowledgments, xii

Section 1 Understanding the Liver

1 Structure, Function, and Repair of the Liver, 3
Christoph Leiskau and Ulrich Baumann

2 Liver Pathology in Children, 18
Rachel M. Brown

3 Liver Immunology and Its Application in Diseases, 24
Hannah C. Jeffery, Kathryn Stirling, and Ye Htun Oo

4 Molecular Genetics and Liver Disease, 34
Paul Gissen

Section 2 Investigating the Liver

5 Useful Investigations in the Assessment of Liver Disease, 41
Way S. Lee and Deirdre A. Kelly

Section 3 Supporting the Child and Family

6 Multidisciplinary Approach to Liver Disease, 59

6.1 The Role of the Multidisciplinary Team, 60
Lindsay Hogg

6.2 The Role of the Dietitian, 68
Sara Clarke and Kelly Guthrie

6.3 The Role of the Psychologist, 76
Jacqueline Blyth

Section 4 Liver Disease in Pregnancy

7 The Effects of Liver Disease in Pregnancy on Mother and Child, 83
Jane Hartley and Hanns�]Ulrich Marschall

Section 5 Liver Disease in Infancy

8 The Jaundiced Baby, 99
Jane Hartley

9 The Acutely Ill Baby, 127
Patrick J. McKiernan

10 Neonatal Hemochromatosis, 144
Amy G. Feldman, Estella M. Alonso, and Peter F. Whitington

Section 6 Liver Disease in Older Children

11 Autoimmune Liver Disease, 155
Giorgina Mieli�]Vergani and Diego Vergani

12 Drug�]Induced Liver Disease, 169
Noelle H. Ebel and Karen F. Murray

13 Viral Hepatitis, 191
Mona Abdel�]Hady and C. Y. William Tong

14 Congenital and Structural Abnormalities of the Liver, 211
Larissa Kerecuk and Patrick J. McKiernan

15 Non�]Alcoholic Steatohepatitis in Childhood, 227
Claudia Della Corte, Antonella Mosca, Vincenzina Lucidi, Arianna Alterio, and Valerio Nobili

16 Hepatobiliary Disease in Cystic Fibrosis, 241
Carla Colombo and Dominique Debray

Section 7 Acute Liver Disease

17 Non�]Viral Infectious Liver Disease, 259
Samantha M. Lissauer and Shiva Ramroop

18 Acute Liver Failure, 271
Estella M. Alonso and Robert H. Squires

Section 8 Metabolic Liver Disease

19 Metabolic Liver Disease in the Infant and Older Child, 291
Anupam Chakrapani and Paul Gissen

20 Disorders of Copper Metabolism, 323
Thomas Müller and Stuart Tanner

Section 9 Management of Chronic Liver Disease

21 Complications and Management of Chronic Liver Disease, 343
Noelle H. Ebel and Simon P. Horslen

Section 10 The Liver and Other Organs

22 The Liver in Systemic Illness, 369
Sue V. Beath

23 Skin Disorders in Liver Disease, 389
Indra D. M. van Mourik, Malobi I. Ogboli, and Michelle Thomson

24 Dental Care of Children with Liver Disease, 405
Marie Therese Hosey and Victoria Clark

Section 11 Surgical Disorders of the Liver and Bile Ducts

25 Biliary Atresia and Other Causes of Surgical Jaundice in Infancy, 415
Erica Makin and Mark Davenport

26 Liver Trauma in Children, 430
A. B. (Sebastian) van As and Alastair J. W. Millar

27 Surgical Management of Portal Hypertension, 439
Jean de Ville de Goyet

28 Primary Hepatic Tumors, 459
Bruce Morland and Khalid Sharif

29 Disorders of the Pancreas, 479
Heiko Witt, Narendra Battula, and Darius Mirza

Section 12 Transplantation

30 Anesthesia and Intensive Care in Pediatric Liver Disease, 501
Peter Bromley, James Bennett, and Richard Neal

31 Liver Transplantation, 512
Deirdre A. Kelly and Paolo Muiesan

32 Small�]Bowel Transplantation in Children, 538
Girish L. Gupte and George Mazariegos

33 Combined Liver and Kidney Transplantation, 556
Thamara Perera and David V. Milford

Section 13 Liver Disease Around the World

34 Liver Disease in the Developing World, 571
Vidyut Bhatia, Wafa’a Al�]Qabandi, Elizabeth Goddard, Seng Hock Quak, and Anupam Sibal

Section 14 Pediatric Liver Disease in Adult Life

35 Transition to Adult Care, 595
Jo Wray and Jessica Wright

36 Pediatric Liver Disease: Surviving to Adult Life, 608
James Ferguson

Index, 615

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The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.