Dx/Rx: Upper Gastrointestinal Malignancies:

Tightly organized into a super-condensed, outline bulleted format, this handy, pocket-sized manual details precise, up-to-date information for diagnosis and treatment of esophageal and, gastric cancers. Comprehensive and concise, the book covers epidemiology, diagnosis, staging, treatment, and complications. Throughout the handbook, tables and figures summarize important clinical data and current professional society recommendations, while salient references direct readers to additional information. Current, quick, and concise, for instant access on ward or in the clinic!

Editor's Preface

ix

Introduction

1

(2)

Scope of Upper Gastrointestinal Malignancies

1

(1)

Prognosis

1

(1)

References

2

(1)

Section I Gastric Cancer

3

(90)

Epidemiology and Pathology

5

(16)

Epidemiology

5

(1)

Demographics

6

(1)

Risk Factors

7

(3)

Pathology

10

(6)

Uncommon Types of Gastric Carcinoma

16

(1)

References

17

(4)

Gastric Cancer Stage and the Staging Evaluation

21

(12)

TNM Stage

21

(4)

Prognostication

25

(1)

Stage Evaluation

25

(3)

Computed Tomography (CT)

28

(1)

Positron Emission Tomography (PET)

28

(1)

Laparoscope

29

(1)

Standard Staging Evaluation (Modified from National Comprehensive Cancer Network [NCCN] Guidelines)

29

(1)

References

30

(3)

Surgery for Stomach Cancer

33

(4)

References

36

(1)

Locally Advanced Gastric Cancer

37

(20)

Background

37

(1)

Patterns of Relapse

37

(2)

Selected Studies of Adjuvant Radiation

39

(3)

Intergroup 0116 (INT-116)---The New Standard of Care for Adjuvant Therapy

42

(6)

Preoperative Therapy---Remains Investigational

48

(4)

References

52

(5)

Treatment of Metastatic Disease

57

(24)

Introduction

57

(1)

Goals of Treatment

57

(2)

Traditional Chemotherapy: Single Agents and Combinations

59

(1)

Recent Phase III Studies of ``Traditional'' Combination Regimens

60

(5)

Epirubicin, Cisplatin, and Infusional Fluorouracil (ECF): A Reference Standard?

65

(1)

Taxanes and Irinotecan as New Cytotoxic Drugs in the Treatment of Gastric Cancer

66

(6)

Other Cytotoxic Drugs

72

(3)

Conclusions

75

(1)

References

76

(5)

Common Nonadenocarcinoma Gastric Cancers

81

(12)

Gastric Carcinoid

83

(3)

Gastrinoma

86

(1)

Next-Generation Drugs for these Uncommon Malignancies

86

(3)

References

89

(4)

Section II Esophagus Cancer

93

(52)

Epidemiology

95

(8)

Epidemiology

95

(3)

Demographics

98

(1)

Risk Factors

98

(2)

Pathology

100

(1)

References

101

(2)

Esophageal Cancer Stage and the Staging Evaluation

103

(8)

Introduction

103

(1)

TNM Stage

103

(3)

Prognostication

106

(1)

Staging Evaluation

107

(1)

Endoscopy

107

(1)

Endoscopic Ultrasonography (EUS)

107

(1)

Computed Tomography (CT)

108

(1)

Positron Emission Tomography (PET)

108

(1)

Laparoscopy

108

(1)

Bronchoscopy

108

(1)

References

109

(2)

The Management of Locally Advanced Esophagus Cancer

111

(20)

Introduction

111

(1)

Surgery

111

(1)

Chemoradiation

112

(5)

Chemoradiation Plus Surgery

117

(4)

Preoperative or Postoperative Chemotherapy

121

(5)

Summary Statements

126

(1)

Comments

126

(1)

Treatment Algorithm

127

(1)

Future

127

(1)

References

128

(3)

Treatment of Metastatic Esophagus Cancer

131

(14)

Introduction

131

(1)

Esophagus Cancer

131

(1)

Goals of Care: Palliation and Dysphagia Relief

132

(1)

Chemotherapy Regimens: Single Agents

133

(1)

Chemotherapy Combinations

134

(3)

Conclusions

137

(2)

References

139

(6)

Section III Gastric and Esophageal Cancers

145

(16)

Common and Unusual Gastric and Esophagus Cancer-Associated Complications

147

(6)

Gastric Cancer

147

(3)

Esophagus Cancer

150

(1)

References

151

(2)

A Look to the Future

153

(6)

Cancer Stem Cells

153

(1)

Chemotherapy

153

(3)

References

156

(3)

Epilogue

159

(2)

Index

161

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Dx/Rx: Upper Gastrointestinal Malignancies: Cancers of the Stomach and Esophagus

Summary

Table of Contents

Supplemental Materials