Etiology and Treatment of Acute Lung Injury: From Bemch to Bedside

, by Matalon, Sadis; Sznajder, Jacob Iasha

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ISBN: 9781586031831 | 158603183X
Cover: Hardcover
Copyright: 6/1/2001

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This book contains contributions of internationally known basic scientists and clinicians with expertise in various aspects of lung injury and repair. This monogram on the pathophysiology and treatment of Acute Lung Injury contains five different sections, each one with contributions from both basic and clinical scientists, outlining existing controversies, an how they can be resolved by future multidisciplinary studies. The various sections discuss: sodium transport and fluid clearance across the normal and injured lungs, the role of the pulmonary surfactant in the pathogenesis and treatment of ARDS, mechanisms and modification of acute and chronic lung injury, ventilatory strategies for the management of acute respiratory distress syndrome and nitric oxide: friend or foe.

Introduction	p. vii
Acknowledgements	p. ix
List of Contributors	p. x
Historical Perspective
A Brief History of ARDS	p. 3
Strategies for the Treatment of Acute Lung Injury
Immunomodulating Strategies in Acute Respiratory Distress Syndrome	p. 19
Mechanical Ventilation for the Acute Respiratory Distress Syndrome (ARDS): How Far Do We Need to Reduce Tidal Volume?	p. 29
Reduced Mortality in Acute Lung Injury and the Acute Respiratory Distress Syndrome with Lung Protective Ventilation with Small Tidal Volumes	p. 35
Does Knowledge of the Infectious Agent Make a Difference in the Treatment of Nosocomial Infections?	p. 43
Selecting Measures for Assessing Quality of Life after Intensive Care	p. 48
Should NO Be Used in the Treatment of Acute Lung Injury? YES	p. 55
Nitric Oxide Treatment of the Acute Respiratory Distress Syndrome	p. 65
Use of Glucocorticoids in the Treatment of the Acute Respiratory Distress Syndrome	p. 70
The Art and Science of Weaning Patients with Acute Lung Injury from the Ventilator	p. 78
Pathogenesis and Prevention of Acute and Chronic Lung Disease in Newborn Infants	p. 86
Gene Therapy for Acute Lung Injury	p. 93
Basic Mechanisms of Lung Injury
Biological Markers of Acute Lung Injury	p. 103
The Role of Neutrophils in Acute Lung Injury	p. 113
Signal Transduction Pathways in Lung Epithelial Cells	p. 124
Apoptosis and Injury	p. 132
Transgenic Modeling of Mechanisms of Protection in Acute Lung Injury	p. 140
Macrophage Migration Inhibitory Factor (MIF) and Acute Lung Injury	p. 151
Role of Tyrosine Phosphorylation in Reactive Oxygen Species-Mediated Vascular Endothelial Cell Barrier Dysfunction	p. 158
Redox Signalling in Human Vascular Cells: Is There an Antioxidant Stress?	p. 169
Ethanol Ingestion, via Glutathione Depletion, Impairs Alveolar Epithelial Function and Renders the Lung Susceptible to Acute Injury during Oxidative Stress	p. 174
Exhaled Nitric Oxide (NO) in Acute Lung Injury: Measurements and Physiological Implications	p. 186
Immune Status Evaluation in Bronchoalveolar Lavage in Critically Ill ICU Patients with ALI	p. 197
Solute and Solvent Flux Across the Blood-Gas Barrier: Basic Mechanisms and Physiological Implications
Intracellular Signals Regulating Na[superscript +],K[superscript +]-ATPase Traffic: The Protein Kinase C Pathway	p. 209
Regulation by Hypoxia of Sodium Transport Proteins in Alveolar Epithelium	p. 215
Aquaporins: Does Gene Expression Translate to Functional Importance in Lung Fluid Balance?	p. 222
Dopamine Effects on Na,K-ATPase Regulation and Alveolar Fluid Reabsorption	p. 227
Host Defense Properties of the Lung
Role of Reactive Oxygen and Nitrogen Species in the Pathogenesis of Pulmonary Viral Infections	p. 237
Transgenic Mice in Studies of Host Defense: Basic Principles for Good Science	p. 248
Mechanisms of Pseudomonas Aeruginosa-Induced Injury to the Alveolar Epithelium	p. 254
Cellular and Physiological Responses in Hypoxia
New Concepts in the Regulation of Lung Endothelial Cell Nitric Oxide Synthase by Hypoxia	p. 263
Mechanisms of Nuclear Factor Kappa B (NF-[kappa]B) Activation in Response to LPS and Hypoxia	p. 272
Role of Mitochondrial Oxidant Signaling in the Cellular Responses to Hypoxia	p. 279
Author Index	p. 289
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Etiology and Treatment of Acute Lung Injury: From Bemch to Bedside

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