Evidence-based Obstetrics and Gynecology

The most comprehensive evidence-based guide to both obstetrics and gynecology 

Aimed at practicing obstetricians, gynecologists, and trainees in the specialty, Evidence-based Obstetrics and Gynecology concentrates on the clinical practice areas of diagnosis, investigation and management. The first section of the book discusses evidence-based medicine methodology in the context of the two specialties. The second and third sections cover all the major conditions in obstetrics and gynecology, with each chapter reviewing the best available evidence for management of the particular condition. The chapters are structured in line with EBM methodology, meaning the cases generate the relevant clinical questions.

Evidence-based Obstetrics and Gynecology provides in-depth chapter coverage of abnormal vaginal bleeding; ectopic pregnancy; pelvic pain; lower genital tract infections; contraception and sterilization; breast diseases; urogynecology; endocrinology and infertility; puberty and precocious puberty; cervical dysplasia and HPV; cervical, vaginal, vulvar, uterine, and ovarian cancer; preconception care; prenatal care and diagnosis; drugs and medications in pregnancy; maternal complications; chronic hypertension; diabetes mellitus; thyroid disease; neurologic disease; psychiatric disease; postterm pregnancy; fetal complications; preeclampsia; and more. 

• First book to address evidence-based practice for obstetrics and gynecology combined
• EBM is a highly relevant approach for this high risk specialty
• Edited by leading US specialist involved in the evidence-based medicine movement

Evidence-Based Obstetrics and Gynecology is an important text for obstetricians and gynecologists in practice and in training, as well as for specialist nurses.

Edited by

Errol R. Norwitz, MD, PhD, MBA, is the Louis E. Phaneuf Professor of Obstetrics & Gynecology at Tufts University School of Medicine in Boston, MA, USA. Dr. Norwitz trained at Cape Town, Oxford and Harvard Schools of Medicine and is closely involved in the evidence based medicine movement. He is also the Chief Scientific Officer and Chair of Department of Obstetrics & Gynecology at the Tufts Medical Center.

Carolyn M. Zelop, MD, is the Director of Ultrasound and Perinatal Research in the Division of MFM and Department of Obstetrics and Gynecology at The Valley Hospital, Ridgewood, NJ, and a Clinical Professor of Obstetrics and Gynecology at the NYU School of Medicine, New York, NY, USA.

David A. Miller, MD, is a Professor of Obstetrics and Gynecology at the Division of Maternal-Fetal Medicine at Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

David L. Keefe, MD, is the Stanley H. Kaplan Professor of Obstetrics and Gynecology, at the NYU Langone Medical Center, New York, NY, USA.

List of contributors, ix

1 Evidence-based medicine in obstetrics and gynecology, 1
Jeanne-Marie Guise

Section 1 Gynecology
David L. Keefe

General Gynecology

2 Abnormal menstrual bleeding, 13
Cynthia Farquhar and Julie Brown

3 Termination of pregnancy, 21
Richard Lyus and Patricia A. Lohr

4 Miscarriage and ectopic pregnancy, 33
Celso Silva and Anita Patel

5 Pelvic pain, 49
Jane Moore

6 Genital tract infections, 55
Veronica Ades

7 Uterine fibroids, 63
David L. Kulak and James H. Segars

8 Endometriosis and adenomyosis, 75
Maria Victoria Vargas and Kathy Huang

9 Contraception and sterilization, 89
Rasha S. Khoury and Danielle M. Roncari

Urogynecology

10 Pelvic floor prolapse/urinary incontinence, 101
Scott W. Smilen, Kimberley Ferrante, Dianne Glass, and Dominique Malacarne

Reproductive endocrinology and infertility

11 Amenorrhea, 109
A. Reza Radjabi and David L. Keefe

12 Polycystic ovarian syndrome, 117
Lubna Pal and Shefali Pathy

13 Recurrent pregnancy loss, 131
H. J. A. Carp

14 Unexplained infertility, 145
Anne-Sophie Boes, Diane De Neubourg, Karen Peeraer, Carla Tomassetti, Christel Meuleman, and Thomas D’Hooghe

15 Menopause and HRT, 155
Jenna Friedenthal, Frederick Naftolin, Lila Nachtigall, and Steven Goldstein

Gynecologic oncology

16 Cervical cancer, 165
Jovana Y. Martin, Britt K. Erickson, and Warner K. Huh

17 Vulval/vaginal cancer, 173
Jessica Lee and John P. Curtin

18 Endometrial cancer, 181
Stephanie V. Blank and Zachary P. Schwartz

19 Cervical dysplasia and HPV, 189
Mila de Moura Behar Pontremoli Salcedo and Kathleen M. Schmeler

Section 2 Obstetrics
Carolyn M. Zelop

General obstetrics

20 Preconception care, 201
Haywood Brown

21 Prenatal diagnosis, 213
Lisa C. Zuckerwise, Karen Archabald, and Joshua Copel

22 Hyperemesis gravidarum, 225
Veronica Gillispie and Sherri Longo

23 Drugs and medication in pregnancy, 233
Maisa N. Feghali and Steve N. Caritis

Maternal complications

24 Asthma, 24
Jennifer A. Namazy and Michael Schatz

25 Hypertensive disorders of pregnancy, 255
Andrei Rebarber

26 Cardiovascular disease, 265
Megan L. Jones and Michael R. Foley

27 Renal disease, 287
Arun Jeyabalan

28 Diabetes mellitus, 297
Margaret Dziadosz and Ashley S. Roman

29 Thyroid disease, 303
Sarah J. Kilpatrick

30 Neurologic disease, 315
Peter W. Kaplan, Emily L. Johnson, and Payam Mohassel

31 Diagnosis and management of antiphospholipid syndrome, 325
Cara Heuser and Ware Branch

32 Hematologic disease, 335
Peter W. Marks

33 Infections in pregnancy, 343
Jennifer Amorosa, Jane Goldman, and Rhoda Sperling

34 Venous thromboembolic disease, 355
B. Ryan Ball and Michael J. Paidas

35 Gastrointestinal disorders, 365
Shivani R. Patel and Richard H. Lee

36 Psychiatric disease, 377
Michael K. Simoni and Kimberly Yonkers

37 Preterm labor, 385
Joses A. Jain and Cynthia Gyamfi-Bannerman

38 Preterm premature rupture of membranes (PPROM), 397
George Graham and Stephanie Bakaysa

39 Antepartum hemorrhage, 407
Joanna Gibson, Nada Sabir, and James Neilson

40 Vaginal birth after cesarean delivery, 419
Carolyn M. Zelop

41 Post-term pregnancy, 431
John Smulian and Joanne Quinones

Fetal complications

42 Disorders of amniotic fluid volume, 443
Marie Beall and Michael Ross

43 Disorders of fetal growth, 451
Katherine R. Goetzinger and Anthony O. Odibo

44 Multiple pregnancies and births, 467
Isaac Blickstein and Oren Barak

45 Intrauterine fetal demise, 479
Rana Snipe Berry

46 Fetal anomalies, 487
Ashley T. Peterson and Sabrina D. Craigo

47 Antepartum/intrapartum fetal surveillance, 495
David A. Miller

48 Hydrops fetalis, 513
Joong Shin Park

49 Malpresentation, 521
Joseph G. Ouzounian and Shivani R. Patel

Peripartum complications

50 Induction/augmentation of labor, 527
Christine Farinelli, Lili Sheibani, and Deborah Wing

51 Postpartum hemorrhage, 545
Alexandria J. Hill, Karin Fox, and Stephanie R. Martin

52 Obstetric emergencies, 559
Karin Fox, Alexandria J. Hill, and Stephanie R. Martin

53 Methods for spontaneous delivery, 569
Carrie Lynn Johnson

54 Operative vaginal delivery, 583
Gary A. Dildy and Steven L. Clark

55 Cesarean delivery in the obese parturient, 593
Diana A. Racusin and Alex C. Vidaeff

Index, 601

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