Experimental Models of Diabetes

An extremely useful text for research Internationally renowned experts describe the models, provide data obtained with those models, and discuss the relative usefulness of models in relation to the diabetic syndrome in humans. The first section examines the most widely used model, the streptozotocin (STZ) rat, condensing a massive quantity of literature to present both the general effects of of STZ diabetes and the effects on individual organ systems. The second section discusses less well-known and more recent diabetic models, such as the BB rat, the NOD mouse and Zucker and Zucker Diabetic Fatty rat models.Genetic models of insulin dependent diabetes mellitus (IDDM) are examined and compared to chemically induced IDDM models.

Christopher R. Barnett: Diabetes Research Group, School of Biomedical Sciences, University of Ulster, Coleraine, County Londonderry, Northern Ireland, United Kingdom Mary L. Battell: Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Canada Sharon Butler: Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada Subrata Chakrabarti: Department of Pathology, University of Western Ontario, London, Canada Catherine J. Field: Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada Peter R. Flatt: Diabetes Research Group, School of Biomedical Sciences, University of Ulster, Coleraine, Country Londonderry, Northern Ireland, United Kingdom Jeffrey C. Flynn: Department of Medicine, University of Illinois at Chicago Ivan C. Gerling: Department of Medicine, University of Tennessee, Memphis Dong Cheol Han: Hyonam Kidney Laboratory, Soon Chun Hyang University, Seoul, Korea and Penn Center for Molecular Studies of Kidney Diseases, Renal -- Electrolyte and Hypertension of Pennsylvania, School of Medicine, Philadelphia Anthony R. Hebden: Heart and Stroke Foundation of British Columbia and Yukon, Vancouver, Canada Costas Ioannides: Molecular Toxicology Group, School of Biological Sciences, University of Surrey, Guildford, England, United Kingdom Krista M. Kivilo: Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio Edward H. Leiter: The Jackson Laboratory, Bar Harbor, Maine Gary D. Lopaschuk: Cardiovascular Research Group and Departments of Pediatrics and Pharmacology, University of Alberta, Edmonton, Canada Kathleen M. MacLeod: Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Canada Christopher H.S. McIntosh: Department of Physiology, The University of British Columbia, Vancouver, British Canada John H. McNeill: Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Canada Andras Mogyorosi: Penn Center for Molecular Studies of Kidney Diseases, Renal-Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia Mahmood Mozaffari: School of Dentistry, Oral Biology/Pharmacology, Medical College of Georgia, Augusta Raymond A. Pederson: Department of Physiology, The University of British Columbia, Vancouver, Canada Patrick Poucheret: Laboratoire de Pharmacodynamie, Faculte de Pharmacie, Universite de Montpellier II, France Brian Rodrigues: Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Canada Stephen W. Schaffer: Department of Pharmacology, School of Medicine, University of South Alabama, Mobile Kumar Sharma: Division of Nephrology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania William C. Stanley: Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio Ramaswamy Subramanian: Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Canada Subodh Verma: Division of Cardiology, Faculty of Medicine, University of Calgary, Alberta, Canada Violet G. Yuen: Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Canada Fuad N. Ziyadeh: Penn Center for Molecular Studies of Kidney Diseases, Renal-Electrolyte Division, Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia