Genetic Effects on Environmental

Much research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. A gene-environment interaction approach assumes that environmental pathogens cause disorder, whereas genes influence susceptibility to environmental pathogens.This book brings together contributions from experts from multiple disciplines who discuss: How epidemiological cohort studies can better integrate physiological (mechanistic) measures; How best to characterise subjects' vulnerability versus resilience by moving beyond single genetic polymorphisms; How gene hunters can benefit from recruiting samples selected for known exposures; How environmental pathogens can be used as tools for gene hunting; How to deal with potential spurious (statistical) interactions, and How genes can help explain fundamental demographic properties of disorders (e.g. sex distribution, age effects).

Prof Sir Michael Rutter, King's College, London, UK
Prof Rutter is the leading child psychiatrist in the UK. He set up the MRC Child Psychiatry Research Unit and the Institute of Psychiatry's Social, Genetic and Developmental Psychiatry Centre. He was Deputy Chairman of the Wellcome Trust from 1999 to 2004, and has been a Trustee of the Nuffield Foundation since 1992. He was elected a Fellow of the Royal Society in 1987 and an honorary member of the British Academy in 2002.?He was a Founding Fellow of the Academia Europaea and the Academy of Medical Sciences, of which he is currently Clinical Vice-President.
He has published extensively.

Introduction: whither gene-environment interactions?	p. 1
Gene-environment interaction: overcoming methodological challenges	p. 13
Discussion	p. 26
Gene-environment interaction and behavioral disorders: a developmental perspective based on endophenotypes	p. 31
Discussion	p. 41
Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events: an application of Item Response Theory	p. 48
Discussion	p. 59
Appendix	p. 64
General discussion I	p. 68
Role of gene-stress interactions in gene finding studies	p. 71
Discussion	p. 83
Practice and public policy in the era of gene-environment interactions	p. 87
Discussion	p. 97
Gene-environment interaction and the metabolic syndrome	p. 103
Discussion	p. 119
General discussion II	p. 122
Longitudinal studies of gene-environment interaction in common diseases-good value for money?	p. 128
Discussion	p. 138
Gene-environment interactions in breast cancer	p. 143
Discussion	p. 150
Unbiased forward genetics and systems biology approaches to understanding how gene-environment interactions work to predict susceptibility and outcomes of infections	p. 156
Discussion	p. 165
Gene-environment interactions in environmental lung diseases	p. 168
Discussion	p. 178
General discussion III	p. 181
Gene-environment interaction in complex diseases: asthma as an illustrative case	p. 184
Discussion	p. 192
Conclusions: taking stock and looking ahead	p. 198
Glossary	p. 206
Index of contributors	p. 215
Subject index	p. 217
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Genetic Effects on Environmental Vulnerability to Disease

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Author Biography

Table of Contents

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