Genetic Variation

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ISBN: 9781603273664 | 1603273662
Cover: Hardcover
Copyright: 9/16/2010

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The study of genetic variation is a multi-step process with iterative involvement of bioinformatics and bench methods. This volume attempts to reflect this, focusing on each of these stages in detail as it applies to different forms of genetic variation.

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Methods in Molecular Biology
Genetic Variation edition
Eds Dr Michael Barnes (GSK) and Dr Gerome Breen (SGDP)
Draft Chapter titlesIx=Informatics chapter
Lab=Lab method chapter
The Genomic Landscape
Introduction
Genome Visualisation (Ix)
Genetic variation in a genomic context
HapMap (Ix)
introduction to LD and haplotypes
Gross genomic variation
Cytogenetic analysis methods (Lab)
Breakpoint and Translocation analysis
FISH
Cytogenetic Informatics (Ix)
Copy number variation (CNV)
Analysis Somatic/Cancer (Lab)
Copy number variation (CNV)
Analysis Germline (Lab)
CNV informatics and databases (Ix)
Evan Eichler? Or lab member?
Micro variation
Microsatellite analysis methods (Lab)
Microsatellite Informatics and databases (Ix)
Gerome Breen and David Collier
SNP genotyping methods (Lab)
SNP informatics and databases (Ix)
dbSNP
SNP database resources
Whole genome resequencing for the analysis of variation (Lab)454, Ilumina?
Beyond the chromosome
Mitochondrial analysis (Lab)
Mitochondrial informatics (Ix)
Epigenetic Analysis methods (Lab)
Peter Laird? Uni SoCal
DNA Methylation
Chromatin analysis
Epigenetic Informatics (Ix)
Sanger EPIgen group
Understanding Variation in Disease
Evaluating the impact of variation (Ix)
Review functional analysis of variation
Sean Mooney?
Expression as a quantitative trait (Ix)
Barbara Stranger (Sanger)
Disease variation databases (Ix)
Locus specific/mendelian databases
Disease association databases
Analysing signatures of natural selection in genetic variation data (Ix)
Nicole Soranzo?
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Genetic Variation

Summary

Table of Contents

Supplemental Materials