Growth Factors in Development

Note: Supplemental materials are not guaranteed with Rental or Used book purchases.

ISBN: 9780123859754 | 0123859751
Cover: Hardcover
Copyright: 11/17/2011

Buy New

Print on Demand: 2-4 Weeks. This item cannot be cancelled or returned.

$221.64
eBook

Available Instantly

Online: 1825 Days

Downloadable: Lifetime Access

$229.50

This new volume of the renowned serial Current Topics in Developmental Biology covers the important features of growth factors in development. With an international board of authors, this volume will be invaluable for researchers in cell, developmental and molecular biology. Provides researchers an overview and synthesis of the latest research findings and contemporary thought in the area This volume provides an up-to-date and timely perspective

Contributors	p. ix
Preface
New Insights into Signaling During Myelination in Zebrafish	p. 1
Introduction	p. 2
Schwann Cell Development	p. 2
Neuregulin1/ErbB Signaling	p. 4
Gpr126	p. 8
New Roles for Schwann Cells	p. 9
Oligodendrocytes	p. 11
Conclusions and Future Directions	p. 13
Acknowledgments	p. 13
References	p. 14
Wnt Signaling: Signaling at and Above the Receptor Level	p. 21
Overview of Wnt Signal Transduction Cascades	p. 22
Wnt Proteins: Different Branches of Signaling	p. 23
Regulation of Wnt Signaling Above the Receptor Level	p. 30
Regulation of Wnt Signaling Pathways at the Receptor Level	p. 40
Conclusions and Perspective	p. 42
Acknowledgments	p. 44
References	p. 44
Notch-Independent Functions of CSL	p. 55
Introduction	p. 56
CSL as a Repressor	p. 59
CSL as a Notch-Independent Transcriptional Activator	p. 62
Role of cis-Regulatory Modules in Determining Target Gene Transcription	p. 66
Role of Competition Between CSL-Containing Complexes-Is CSL a Limiting Factor?	p. 67
Concluding Remarks	p. 68
Acknowledgments	p. 69
References	p. 69
Sonic Hedgehog Signaling in the Developing CNS: Where It Has Been and Where It Is Going	p. 75
Prologue: Identification of Shh	p. 76
Setting the Stage: Shh Signaling During Nervous System Regionalization	p. 77
I Am Dying to Hear from You: The Range of Shh Signaling in the CNS	p. 78
Character Creation: Production and Secretion of Shh Protein	p. 79
Won't You Take My Hand: Shh-Binding Proteins and Diffusion	p. 81
Character Development: Transduction of Shh Signal in Receiving Cells	p. 84
Cutting in on the Dance: The Interplay Between Ptc and Smo	p. 86
Taking It to the Extreme: The Central Role of the Primary Cilium in Shh Signaling	p. 86
Stepping into the Dark: How Does Smo Control Gli Phosphorylation?	p. 89
Are You Going to Use That Thing? Smo as a G-Protein-Coupled Receptor	p. 92
Being in the Right Place at the Right Time: Shh-Gli Signaling and Patterning in the Ventral Neural Tube	p. 94
Walking Down the Runway: A Model for Shh-Gli Control of Early Progenitor Patterning	p. 97
What's It Gonna Be, Boy? GliA Versus GliR-Regulated Genes	p. 99
New Game: Distinct Mechanisms for GliA-and GliR-Mediated Transcription	p. 101
Summary and Further Questions	p. 104
References	p. 105
Activity-Mediated Synapse Formation: A Role for Wnt-Fz Signaling	p. 119
Introduction	p. 120
Wnts and Their Receptors	p. 120
The Role of Wnt Signaling in Synapse Formation	p. 122
Role of Neuronal Activity in Wnt-Mediated Dendrite Morphogenesis	p. 128
Role of Neuronal Activity in Wnt-Mediated Synapse Formation	p. 129
Concluding Remarks	p. 132
Acknowledgments	p. 132
References	p. 132
Signaling Pathways and Axis Formation in the Lower Metazoa	p. 137
Introduction	p. 138
Animal Relationships and the Origin of the Basal Metazoa	p. 141
Wnt Signaling	p. 145
TGF-ß and BMP Signaling	p. 149
Negative Regulators of BMP and Wnt Signaling	p. 154
Axis Formation and Regeneration in Basal Metazoans	p. 156
Conclusions and Outlook	p. 165
Acknowledgment	p. 166
References	p. 166
FGF and ROR2 Receptor Tyrosine Kinase Signaling in Human Skeletal Development	p. 179
Introduction	p. 180
FGF Signaling: Craniosynostosis, Digit Abnormalities, and Short Stature	p. 183
The Atypical Receptor TK ROR2 and WNT Signaling	p. 190
References	p. 196
Index	p. 207
Contents of Previous Volumes	p. 211
Table of Contents provided by Ingram. All Rights Reserved.

Please wait while the item is added to your bag...

FREE SHIPPING

Amazon no longer offers textbook rentals. We do!

Growth Factors in Development

Summary

Table of Contents

Supplemental Materials