Handbook of Psychiatric Drugs

TheHandbook of Psychiatric Drugs is a comprehensive, clear, concise and quick reference to psychiatric drug therapies, designed to guide the clinician on the selection and implementation of treatment for mental illness.Each chapter is organised by drug class and follows a standard format for ease of use. Concise sections on pharmacology and indications for use are followed by detailed information on drug selection, initiation and maintenance of treatment and withdrawal. Adverse effects, contraindications and drug interactions are also reviewed in detail, along with issues such as treatment resistance and treatment evaluation.A handy pocket-sized drug reference, theHandbook of Psychiatric Drugs makes it easy to keep up-to-date with new developments. It is an invaluable resource for all clinicians who use psychiatric drugs to treat medical and psychiatric illness, and an informative read for all those with an interest in the subject.

Jeffrey Lieberman – head of the department of psychiatry at |Columbia University, the most prestigious department in the US, Jeff is a leading psychiatric drug researcher with excellent clinical, academic and publishing credentials. He has excellent connections within the US pharma industry. Allan Tasman – head of the department of psychiatry in Louisville, USA and past president of the APA, Allan has a very high profile in clinical and academic psychiatry in the USA. He is President Elect, Pacific Rim College of Psychiatrists and active in the WPA.

1 Antipsychotic Drugs.

Introduction.

Pharmacology.

Chemistry.

Mechanisms of Action.

Pharmokinetics.

Indications for Use of Antipsychotic Drugs.

Drug Selection and Initiation of Treatment.

Drug Selection for the Treatment of Schizophrenia.

Effects of Antipsychotic Agents on Symptoms of Schizophrenia.

Drug Selection for the Treatment of Bipolar Disorder.

Drug Selection for the Treatment of Major Depression with Psychotic Features.

Drug Selection for the Treatment of Delusional Disorder.

Drug Selection for the Treatment of Delirium.

Drug Selection for the Treatment of Psychosis and Agitation Associated with Dementia.

Drug Selection for the Treatment of Mental Retardation and Developmental Disorders.

Drug Selection for Huntington’s Disease and Tourette’s Disorder.

Substance-induced Psychoses.

Adverse Effects of Antopsychotics.

Acute Extrapyramidal Side Effects (Dystonia, Parkinsonism, Akathisia).

Tardive Dyskinesia and Other Tardive Syndromes.

Neuroleptic Malignant Syndrome.

Endrocrine and Sexual Effects.

Metabolic Effects.

Cardiovascular Effects.

Gastrointestinal Effects.

Hepatic Effects.

Hematological Effects

Other Side Effects

Drug Interactions and Antipsychotic Agents.

Antipsychotic Medications and Pregnancy.

Additional Reading.

2 Antidepressants.

Introduction.

Pharmacology.

Mechanisms of Action.

Pharmokinetics.

Indications for Use of Antidepressants.

Panic Disorder (PD).

Obsessive–Compulsive Disorder (OCD).

Generalized Anxiety Disorder (GAD).

Social Phobias and Posttraumatic Stress Disorder (PTSD).

Bulimia.

Anorexia Nervosa.

Body Dysmorphic Disorder (BDD).

Premenstrual Dysphoria (PMDD).

Childhood Disorders.

Other Psychiatric Disorders.

Drug Selection and Initiation of Treatment for Major Depression.

Special Considerations in the Selection of an Antidepressant.

Initiation of Treatment.

Therapeutic Drug Monitoring.

Early, or Pre-response, Period.

Response, or Acute Treatment, Period.

Treatment of Partially Responsive and Nonresponsive Patients.

Continuation and Maintenance Periods, and Discontinuation.

Anticholinergic Effects.

Autonomic Effects.

Neurologic Effects.

Weight Gain.

Gastrointestinal Symptoms.

Sexual Dysfunction.

Cardiac Conduction.

Suicide Risk.

Allergic and Hematologic Effects.

Other Effects.

Central Serotonergic Syndrome.

Monoamine Oxidase Inhibitors.

Drug Interactions.

Tricyclic Antidepressants.

Pharmacokinetic Effects.

Monoamine Oxidase Inhibitors.

Serotonin Reuptake Inhibitors.

Other Second-generation Antidepressants.

Third-generation Antidepressants.

Summary.

Recommendations for the Use of Antidepressants.

Additional reading.

3 Mood Stabilizers.

Introduction.

Pharmacology.

Chemistry.

Mechanisms of Action.

Pharmokinetics.

Indications.

Drug Selection and Initiation of Treatment.

Acute Mania.

Drug Selection.

Relative Efficacy of Different Agents.

Treatment Initiation and Dose Titration.

Acute Depression.

Drug Selection

Treatment Initiation and Dose Titration.

Breakthrough Episodes.

Maintenance.

Rapid Cycling.

Costs.

Adverse Effects.

Drug Interactions.

Pregnancy.

Summary.

Additional Reading.

4 Anxiolytic Drugs.

Introduction.

A General Approach to Using Medication with Anxious Patients.

Pharmacology.

Antidepressants.

Benzodiazepines.

Buspirone.

Beta-blocker Medications.

Anticonvulsants.

Indications for Use.

Antidepressants.

Benzodiazepines.

Buspirone

Beta-blocker Medications.

Anticonvulsants.

Antipsychotics.

Augmentation/Adjuvant Treatments.

Drug Selection, Dose, and Initiation of Treatment.

Side Effects.

Drug Interactions.

Contraindications and Special Precautions.

Summary.

Additional Reading.

5 Sedative–Hypnotic Agents.

Introduction.

Diagnosis.

Treatment Options.

Nonprescripton Agents.

Prescription Medications.

Pharmacology.

Benzodiazepines.

Chloral Hydrate.

Zolpidem.

Zaleplon.

Eszopiclone.

Ramelteon.

Drug Selection.

Other Prescription Hypnotics.

Treatment Implementation .

Adverse Effects.

Benzodiazepines.

Chloral Hydrate.

Zolpidem.

Zaleplon.

Eszopiclone.

Ramelteon.

Drug Interactions and Special Precautions.

Summary.

Additional Reading.

6 Psychostimulants.

Introduction.

Pharmacology.

Chemistry.

Mechanisms of Action.

Pharmacokinetics.

Indications and Contraindications.

Drug Selection.

Treatment Initiation and Dose Titration.

Treatment Evaluation.

Maintenance Treatment.

Treatment Resistance.

Effects of Treatment on Symptoms.

ADHD in Adults.

Alternative Preparations to the Standard Stimulant Medications.

Narcolepsy.

Other Indications.

Costs.

Adverse Effects.

Drug Interactions.

Summary.

Additional Reading.

7 Cognitive Enhancers and Treatments for Alzheimer’s Disease.

Introduction.

Pharmacology.

Mechanisms of Action.

Pharmacokinetics.

Indications.

Drug Selection.

Treatment Initiation.

Maintenance Treatment.

Treatment Evaluation.

Cost.

Adverse Effects.

Cholinesterase Inhibitors.

Drug Interactions.

Summary.

Additional Reading.

8 Drugs for Treating Substance Abuse.

Introduction.

Syndromes Related to Intoxication.

Alcohol Intoxication.

Sedative–Hypnotic Intoxication.

Opiate Intoxication.

Cocaine and Amphetamine Intoxication.

Hallucinogen [LSD, Mescaline, MDMA (‘Ecstasy’), and Psilocybin] Intoxication.

Phencyclidine Intoxication.

Drugs for the Treatment of Withdrawal Syndromes.

Alcohol Withdrawal.

Sedative–Hypnotic Withdrawal.

Opiate Withdrawal.

Management of Withdrawal in Patients with Multiple Dependencies.

Agents to Aid Relapse Prevention.

Medications for Alcohol Dependence.

Medications for Cocaine Dependence.

Medications for Opiate Dependence.

Special Considerations.

Medications for Nicotine Dependence.

Pharmacotherapies for Substance Abusers with Additional Types of Psychiatric Illness.

Pharmacotherapy for Specific Psychiatric Disorders.

Drug Interactions in Chemical Dependency.

Additional Reading.

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Handbook of Psychiatric Drugs

Summary

Author Biography

Table of Contents

Supplemental Materials