Heat Shock Proteins in Myocardial Protection

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ISBN: 9781587060212 | 1587060213
Cover: Hardcover
Copyright: 8/1/2000

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Medical College of Virginia, Virginia Commonwealth Univ., Richmond. Presents a thorough description of the state of knowledge in this area, the controversies in this field, and the potential of treating ischemic heart disease with heat shock proteins in patients. DNLM: Myocardial--drug effects.

Stress Proteins in Myocardial Protection	p. 1
Heat Stress and the Stress Response	p. 1
Are Stress Proteins Protective?	p. 2
Evidence for the Ability of Stress Proteins to Protect the Cell	p. 2
Conclusions	p. 9
Heat Stress Proteins: A Possible Route to Myocardial Protection	p. 15
Introduction	p. 15
What Are Heat Stress Proteins?	p. 16
Introducing the Major Cardiac Heat Stress Proteins	p. 16
Dynamics of Heat Stress Protein Gene Expression and Regulation	p. 18
Relevance to Myocardial Protection	p. 19
Experimental Models	p. 19
Heat Stress and Models Mimicking Cardiac Surgery	p. 20
Transgenic Animal Models: The Answer to Heat Shock Associated Damage?	p. 21
Proposed Mechanisms for HSP-Mediated Protection	p. 22
Conclusion: Is There a Role for Heat Stress in the Armamentarium of Myocardial Protection?	p. 24
Cardioprotection by Stress Proteins	p. 30
The Mammalian Stress Proteins	p. 30
Myocardial Ischemia	p. 32
Cardioprotection by the Stress Proteins	p. 34
Conclusion	p. 36
Role of Heat Shock Proteins, Protein Kinase C and ATP-Sensitive Potassium Channel in Delayed Myocardial Protection	p. 41
Stress and Ischemic Protection	p. 41
Whole-Body Hyperthermia and Delayed Ischemic Protection	p. 42
Delayed Ischemic Preconditioning--Role of Hsp 72	p. 42
Hsp 72 and Ischemic Protection--Controversies	p. 45
Role of Protein Kinase C	p. 45
Role of KATP Channel	p. 48
Conclusions	p. 50
Hsp 70 and Ischemia Tolerance in the Compromised Heart	p. 55
Stress Proteins in the Aged and Diseased Animal Heart	p. 56
Stress Proteins and Cardiovascular Disease in Humans	p. 58
New Research and Anticipated Developments	p. 61
Conclusions	p. 62
Hsp72 in the Regulation of TNF-[alpha] Production: Mechanistic Implication of Protection Against Postischemic Myocardial Dysfunction	p. 66
Abstract	p. 66
Introduction	p. 66
Hsp70 in Myocardial Protection	p. 67
Myocardial Ischemia and TNF-a Production	p. 68
Hsp70 in the Regulation of TNF-a Production	p. 69
Perspectives	p. 72
Preconditioning of Cardiac Myocytes Studies Using Cultured Neonatal Rat Heart Myocytes and Simulated Ischemia	p. 77
A Model System for Simulated Ischemia/Reperfusion	p. 77
Using the Model to Study Sarcolemmal Processes During Ischemia/Reperfusion	p. 80
Using the Model of Simulated Ischemia in Preconditioning Studies	p. 80
Hsp70 Expression During Preconditioning of Cultured Neonatal Rat Heart Cells	p. 81
The Role of Hsp70 in Preconditioning Cultured Neonatal Rat Heart Cells	p. 83
Antisense, Heat Shock Proteins and the Heart	p. 87
Overview of Antisense Technology	p. 87
Complications and Controls	p. 88
Antisense and the Cardiovascular System	p. 88
Heat Shock Proteins and Antisense	p. 89
Hsp72 (Inducible Hsp70)	p. 89
Heat Shock Protein 60	p. 90
Small Heat Shock Proteins	p. 92
Other Hsp's	p. 92
Conclusions	p. 93
Stress Proteins in Myocardial Protection: Culture Shock Protein, Heme Oxygenase-1 (Hsp32), Induced by Sublethal Stresses Protects the Heart Against Oxidative Stress	p. 96
Increased HO-1 Expression in Myocardial Cells	p. 97
HO-1-Induced Cardioprotection Against Hypoxia-Reoxygenation Injury	p. 102
Sublethal Stress-Induced HO-1 Expression in Myocardial Cells	p. 103
HO-1 as a Rescue Protein in Pharmacological Preconditioning	p. 105
Conclusions	p. 106
Physiological Role of Heat Shock Protein 27	p. 109
Hsp27: A Member of Small Hsp Family	p. 109
Heat Shock Response: Thermoresistance and Increased Tolerance to Stress	p. 110
Physiological Functions of Hsp27	p. 111
Cross-Talk with Oxidative Stress-Inducible Proteins	p. 114
Clinical Significance	p. 115
Summary and Conclusion	p. 116
Ischemia/Reperfusion Injury and Heat Shock Proteins	p. 121
Regulation of Heat Shock Gene Transcription	p. 121
Damage by Ischemia/Reperfusion Injury	p. 122
Induction of Hsp's by Ischemia/Reperfusion in the Heart	p. 124
Hsf Activation by Ischemia/Reperfusion	p. 124
Myocardial Protection Against Ischemia/Reperfusion by Hsp's	p. 125
Signals for Heat Shock Response During Ischemia/Reperfusion	p. 128
Clinical Application and Future Perspective	p. 130
Index	p. 135
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Heat Shock Proteins in Myocardial Protection

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