Hepatotoxicity From Genomics to In Vitro and

This book addresses all the current, up-to-date developments in this scientific discipline. Liver is the chief metabolizing site in the body, and thus, it is a major target organ for drug and chemical toxicity. Therefore, hepatotoxicity is an important endpoint in the safety evaluation of drugs and chemicals. Contributions from leading investigators in hepatotoxicity research address current developments in this scientific discipline and discuss use of current cutting edge technology such as microarrays in hepatotoxicity thus providing a better understanding of hepatotoxins, their interactions and mechanisms of action. This valuable authoritative source of information is the first book to address this topic for nearly ten years, making it an essential resource for readers from a wide range of disciplines such as toxicology, pharmacology, hepatology, drug toxicity and food science.

Dr. Sahu is the US Editor for the Journal of Applied Toxicology.

Contributors
Preface
Acknowledgements
Models For Hepatotoxicity Testing
Current in vitro Models to Study Drug-Induced Liver Injury
Utilization of an in vitro Hepatotoxicity Test in the Early Stage of Drug Discovery
Use of Hepatocytes for Characterizing a Candidate Drug's Metabolism and Drug Interaction Potential
Human-Based in vitro Experimental Systems for the Evaluation of Human Drug Safety
Hepatocytes as a Model for Screening Food-Related Hepatotoxins and Studying Mechanisms of their Toxicity
Some Experimental Models of Liver Damage
Hepatocyte Cultures
Application of Short- and Long-Term Hepatocyte Cultures to Predict Toxicities
Biomarkers Of Hepatotoxicity
Biomarkers of Mycotoxin Exposure in Liver Toxicity
Mechanisms Of Hepatotoxicity
Mechanisms of Toxic Liver Injury
A Role of Cytochrome P450 in Quinone-Induced Hepatotoxicity
A Mechanistic View of Troglitazone Hepatotoxicity
Role of the Kupffer Cell in Hepatotoxicity and Hepatocarcinogenesis
Sinusoidal Cells in Liver Injury and RepairCarol R. Gardner
Cytokines in Liver Diseases
Bile Acids as Modulators of Apoptosis
Drug-Induced Intrahepatic Cholestasis by Interaction with the Hepatic Bile Salt Export Pump (BSEP)
Genomics Of Hepatotoxicity
Application of Toxicogenomics in Predicting Hepatotoxicity - Potentials and Challenges
Genomic Profiling of Liver Injury
Use of DNA Arrays in Understanding Hepatic Test Systems
Prediction of Hepatotoxicity Based on the Toxicogenomics Database
Relationship between N-acetyltransferase-2 Gene Polymorphism and Isoniazid-Induced Hepatotoxicity
Gender Differences In Hepatotoxicity
Human and Animal-Based Differences in Hepatic Xenobiotic Metabolism and Toxicity
Hepatotoxicity And Hepatocarcinogenicity
Hepatotoxicity in Oncology Drug Development
The Potent Rat Hepatocarcinogen Methapyrilene: An Hypothesis Regarding its Hepatotoxicology
Hepatotoxicity And Botanical Supplements
Botanical Supplements and Hepatotoxicity
Risk Analysis Of Hepatotoxins
Physiologically Based Pharmokinetic Modeling and Risk Assessment of Hepatotoxi
Table of Contents provided by Publisher. All Rights Reserved.

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Hepatotoxicity From Genomics to In Vitro and In Vivo Models

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