Hereditary Breast Cancer

Intended for medical oncologists, surgeons, obstetricians, gynecologists, geneticists, genetic counselors, and primary care physicians, this text presents the epidemiological, biological, and clinical issues associated with hereditary breast cancer. It offers clear guidance on the application and utilization of cancer risk assessment models, genetic counseling and testing of high risk patients, and screening and prevention options for individuals at risk of hereditary breast cancer. Addressing every essential aspect of hereditary breast cancer, thissource offers comprehensive analyses of hereditary breast cancer-associated syndromes, low penetrance genes, and hereditary breast cancer associated with mutations in the BRCA1 and BRCA2 genes.

Foreword	p. iii
Preface	p. vii
Contributors	p. xi
Overview of Hereditary Breast Cancer
The Genetic Epidemiology of Hereditary Breast Cancer	p. 1
Risk Prediction in Breast Cancer	p. 19
Bioethics of Genetic Testing for Hereditary Breast Cancer	p. 35
Hereditary Breast Cancer Syndromes with Known Genetic Etiologies
Cancer Risks in BRCA1 and BRCA2 Mutation Carriers	p. 53
PTEN and Cowden Syndrome	p. 79
Li-Fraumeni Syndrome	p. 95
Rare Causes of Inherited Breast Cancer Susceptibility	p. 111
Low-Penetrance Genes in Breast Cancer	p. 127
Assessment and Dissemination of Clinical Risks for BRCA1/2 Mutation Carriers
Biology of BRCA1- and BRCA2-Associated Carcinogenesis	p. 139
Genetic Testing and Counseling Issues	p. 153
Molecular Diagnostics: Methods and Limitations	p. 179
Breast Cancer Risk Modifiers	p. 207
BRCA1 and BRCA2 in Underserved and Special Populations	p. 233
Psychological and Behavioral Impact of BRCA1/2 Genetic Testing	p. 255
Screening and Prevention of Hereditary Breast Cancer
Breast Cancer Screening and Prevention Options in BRCA1 and BRCA2 Mutation Carriers	p. 277
Ovarian Cancer Screening and Prevention Options: Ovarian Cancer Screening and Its Limitations. Who Should be Screened?	p. 301
Management of BRCA-Negative Hereditary Breast Cancer Families	p. 311
Clinical Management of Hereditary Breast Cancer
Pathology of Breast Tumors in Hereditary Breast Cancer	p. 319
Pathology of Ovarian Tumors in Mutation Carriers	p. 333
Local Treatment Issues in Women with Hereditary Breast Cancer	p. 345
Systemic Therapy for BRCA-Associated Breast Cancer	p. 361
Index	p. 377
Table of Contents provided by Ingram. All Rights Reserved.

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Hereditary Breast Cancer

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