Hypoxia and Consequences, Volume 1177

International experts from academia, industry and government discuss the cellular mechanisms that underlie rapid and delayed responses to oxygen deprivation, known as hypoxia. This volume brings together researchers and clinicians from developmental and cellular biology, drug development, oncology, neurobiology and medicine to discuss 1) How hypoxia-inducible factors regulate development and physiology, 2) How cells sense changes in oxygen availability, and 3) How oxygen availability affects several pathologies like pulmonary hypertension, sleep apnea, cancer and neurodegeneration.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order ( www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Chris Peers and Gabriel G. Haddad are the authors of Hypoxia and Consequences, Volume 1177, published by Wiley.

Introduction to Hypoxia and Consequences: From Molecule to Malady
Transcriptional Responses to Hypoxia
Regulation of Vascularization by Hypoxia-Inducible Factor 1
FIH-Dependent Asparaginyl Hydroxylation of Ankyrin Repeat Domain-Containing Proteins
From Polyps to People: A HIghly Familiar Response to Hypoxia
Maintaining Mammalian Iron and Oxygen Homeostasis: Sensors, Regulation, and Cross-Talk
Survival in Acute and Severe Low O₂ Environment: Use of a Genetic Model System
Mitochondria and Hypoxic Signaling: A New View
Pathophysiological Consequences of HIF Activation: HIF as a Modulator of Fibrosis
Mitochondrial Metabolism and Cancer
Oxygen Sensing
Molecular Imaging: Into In Vivo Interaction of HIF-1 and HIF-2 with ARNT
Oxygen-Sensitive Potassium Channels in Chemoreceptor Cell Physiology: Making a Virtue of Necessity
Ion Channel Regulation by AMPK: The Route of Hypoxia-Response Coupling in the Carotid Body and Pulmonary Artery
Hypoxia Selectively Inhibits KCNA5 Channels in Pulmonary Artery Smooth Muscle Cells
Enzyme-Linked Oxygen Sensing by Potassium Channels
Oxygen Sensing in the Carotid Body
Regulation of Oxygen Sensitivity in Adrenal Chromaffin Cells
Oxidative DNA Modifications in Hypoxic Signaling
The Neuronal Control of Hypoxic Ventilation: Erythropoietin and Sexual Dimorphism
Pathophysiological Responses to Hypoxia
Intermittent Hypoxia-Mediated Plasticity of Acute O2 Sensing Requires Altered Red-Ox Regulation by HIF-1 and HIF-2
Hypoxia and Neurodegeneration
The Role of NF-B in Hypoxia-Induced Gene Expression
Role of Hypoxia-Inducible Factors in Epigenetic Regulation via Histone Demethylases
An Essential Role of the HIF-1-c-Myc Axis in Malignant Progression
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Hypoxia and Consequences, Volume 1177

Summary

Author Biography

Table of Contents

Supplemental Materials