Immune Response in the Criticaly Ill

This book brings together basic scientists or clinicians from a variety of different backgrounds - immunology, infectious diseases or critical care - who share a common interest in understanding the changes that occur in immune responses in sepsis. It provides an up to date and unrivalled synthesis of current research in this rapidly developing field.

The Four Ds of the Danger Model: Distress, Damage, Destruction, and Death

1

(12)

P. Matzinger

The Immune Response in Critical illness: Excessive, Inadequate or Dysregulated

12

(10)

J.L. Vincent

Genomics of the Sepsis Syndrome

22

(15)

S. J. H. van Deventer

P. Stokkers

The Pro-Inflammatory Cytokine Cascade

37

(30)

J. M. Cavaillon

M. Adib-Conquy

Inhibitory Cytokines

67

(17)

T. Calandra

D. Heumann

Interleukin-1 β and Interleukin - 18: Two Cytokine Precursors for Interleukin-1 β Converting Enzyme (Caspase-1)

84

(32)

C. A. Dinarello

Bacterial Toxins Induce Specific Cytokine Patterns In Vivo and In Vitro

97

(19)

J. Andersson

U. Andersson

The Acute Phase Response and Enhancing Resistance to Bacterial Infection

116

(24)

M. Noursadeghi

J. Cohen

Cytokines as Mediators of Lung Innate Immunity

140

(15)

T. J. Standiford

B. Merhad

W. C. Tsai

Fetuin Opsonizes Macrophage-Deactivating Cations

155

(9)

H. Wang

K. J. Tracey

LPS Receptors

164

(9)

E. Lien

H. Heine

D. T. Golenbock

Regulation of Cellular Responses to Bacterial Endotoxin

173

(9)

R. J. Ulevitch

The Role of Nitric Oxide in the Initiation of Inflammation in Shock

182

(8)

R. T. Villavicencio

T. R. Billiar

Regulation of Neutrophil Activation in Acute Lung Injury and SIRS

190

(20)

J. Kruger

Q. Dong

G. Downey

Neutrophils and Acute Lung Injury

210

(16)

C. Haslett

S. Donnelly

N. Hirani

Lymphocyte Activation, Anergy, and Apoptosis in Polymicrobial Sepsis

226

(21)

A. Ayala

C. S. Chung

G. Y. Song

Trauma Mediators Favor Differentiation of Monocytes to Macrophage Rather Than to Dendritic Cells

247

(17)

C. L. Miller-Graziano

A. K. De

K. Kodys

Programmed Cell Death (Apoptosis) and the Immunologic Derangements of Critical Illness

264

(16)

R. Taneja

L. Yue

J. C. Marshall

The Interaction Between the Coagulation System and the Systemic Inflammatory Mediators

280

(12)

S. M. Opal

The Endothelium as an Immune Organ: Active Player and Passive Target

292

(20)

H. Redl

Immunoregulation in Shock, Trauma, and Sepsis

312

(23)

E. Faist

M. K. Angele

S. Zedler

Endotoxemia in Healthy Subjects as a Human Model of Inflammation

335

(23)

T. van der Poll

S. J. H. van Deventer

Monitoring Immune Status in Critically Ill Patients

358

(7)

M. R. Pinsky

A. J. Rosenbloom

Tumor Necrosis Factor Receptors in Systemic Inflammation

365

(20)

E. Lin

S. E. Calvano

S. F. Lowry

Cytokine Neutralization: An Overview

385

(8)

E. Abraham

Immunostimulation with Cytokines in Patients with `Immunoparalysis'

393

(12)

H. D. Volk

P. Reinke

W. D. Docke

Prospects for a Vaccine to Prevent Bacterial Sepsis

405

(18)

S. M. Opal

Subject Index

423

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Immune Response in the Criticaly Ill

Summary

Table of Contents

Supplemental Materials