Inflammation and Cardiac Diseases

Heart failure research is a most active area of research in academic, industrial and government-sponsored research and receives intense clinical attention. The recent recognition that inflammation is a risk factor and prognostic factor for heart disease has laid ground for preventive medicine and even anti-infective strategies in prevention and treatment of heart failure.

List of contributors

ix

Introduction

Inflammation -- a new frontier in cardiac disease and therapeutics

1

(8)

Giora Z. Feuerstein

Peter Libby

Douglas L. Mann

Pathological aspects and inflammation biomarkers in cardiac diseases

A biomarker of inflammation in cardiovascular diseases

9

(12)

Giora Z. Feuerstein

Ron Firestein

Douglas L. Mann

Peter Libby

Inflammation and coronary artery disease

21

(36)

Renu Virmani

Frank D. Kolodgie

Allen P. Burke

Andrew Farb

Herman K. Gold

Aloke V. Finn

Inflammatory cells and their metalloproteinases in cardiac diseases

The role of matrix metalloproteinases in LV remodeling following myocardial infarction

57

(20)

Esther E.J.M. Creemers

Jack P.M. Cleutjens

Jos F.M. Smits

Mat J.A.P. Daemen

Matrix metalloproteinases in heart failure: evidence from experimental models

77

(18)

Francis G. Spinale

Inflammatory cytokines in cardiac diseases

The clinical experience with anti-cytokine therapy in heart failure

95

(16)

Anita Deswal

Biykem Bozkurt

Douglas L. Mann

The role of IL-6 and related cytokines in myocardial remodeling and inflammation -- implication for cardiac hypertrophy and heart failure

111

(18)

Antoine Bril

Giora Feuerstein

Toll-like receptors and the cardiovascular system

129

(14)

Stefan Frantz

Ralph A. Kelly

Todd Bourcier

The role of IL-6 in experimental and clinical heart failure

143

(12)

Elaine J. Tanhehco

Hani N. Sabbah

Oxygen and nitrogen reactive radicals in cardiac inflammation and disease

Myocardial nitric oxide in cardiac remodeling

155

(16)

Flora Sam

Douglas B. Sawyer

Wilson S. Colucci

Identification and role of inflammatory oxygen free radicals in cardiac ischemia and reperfusion injury

171

(18)

Catherine Vergely

Gaelle Clermont

Sandrine Lecour

Antoine Bril

Luc Rochette

The immune and complement system and cardiac diseases

Immune-mediated myocarditis and interleukin-10

189

(14)

Kenichi Watanabe

Makoto Kodama

Yoshifusa Aizawa

Immunomodulation in heart failure: experimental models

203

(18)

Shigetake Sasayama

The role of complement in myocardial inflammation and reperfusion injury

221

(30)

Elaine J. Tanhehco

Benedict R. Lucchesi

Inflammatory signaling pathways in cardiac diseases

The role of immune and inflammatory cytokines in ischemic preconditioning of the heart -- identification of novel cardiac cell survival signaling programs

251

(20)

Sandrine Lecour

Robert M. Smith

Michael N. Sack

Stress-activated signals and their role in myocardial ischemia

271

(22)

Masaya Tanno

Michael Marber

p38 MAPK in cardiac remodeling and failure: cytokine signaling and beyond

293

(22)

Thomas M. Behr

Christopher P. Doe

Haisong Ju

Robert N. Willette

Inflammation and myocarditis

315

(10)

Jay W. Mason

The inflammatory process in experimental myocarditis

325

(12)

Noel R. Rose

Marina Afanasyeva

Nuclear factors in cardiac disease

Peroxisome proliferator activated receptors, inflammation, the vasculature and the heart

337

(14)

Quy N. Diep

Farhad Amiri

Ernesto L. Schiffrin

Chemokines and cardiac diseases

Role of chemokines in the pathogenesis of congestive heart failure

351

(20)

Joseph Winaver

Thomas M. Behr

Zaid Abassi

Neurohormonal mediators and cardiac inflammation

The role of endothelin-1 in myocardial inflammation and fibrosis

371

(16)

Li L. Yang

Mansoor Husain

Duncan J. Stewart

Cyclooxygenases and cardiac diseases

Cyclo-oxygenase-2 and myocardial ischemia

387

(12)

Gary F. Baxter

Caroline P.D. Wheeler-Jones

Inflammation and arrhythmias

Inflammation as a cause and consequence of atrial fibrillation

399

(8)

David R. Van Wagoner

Mina K. Chung

Summary: Immune and inflammatory modulators as potential therapeutic targets for cardiac diseases

407

(4)

Giora Z. Feuerstein

Peter Libby

Douglas L. Mann

Index

411

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Inflammation and Cardiac Diseases

Summary

Table of Contents

Supplemental Materials