Intraocular Drug Delivery

Note: Supplemental materials are not guaranteed with Rental or Used book purchases.

ISBN: 9780824728601 | 0824728602
Cover: Hardcover
Copyright: 3/13/2006

Rent

(Recommended)

$136.27

Term

Due

Price

Semester

Dec 13

$151.41

Quarter

Aug 21

$143.84

Short Term

Jul 26

$136.27

*This item is part of an exclusive publisher rental program and requires an additional convenience fee. This fee will be reflected in the shopping cart.
Buy New

Usually Ships in 3-5 Business Days

$206.86
eBook

Available Instantly

Online: 180 Days

Downloadable: 180 Days

$49.48

(Informa) Duke Univ., Durham, NC. Reference presents recent advances in the development of ocular drug delivery systems. Topics include methods to treat or prevent ocular inflammation, retinal vascular disease, retinal degeneration, proliferative eye disease, and the management of edophthalmitis, uvetis, and more. For opthalmologists. DNLM: Drug Delivery System.

Preface

iii

Contributors

xiii

PART I: GENERAL

1. Retinal Drug Delivery

(26)

Paul Ashton

Basic Principles of Drug Delivery

(7)

Drug Delivery to the Posterior Segment of the Eye

(4)

Drug Elimination Mechanisms

(2)

Posterior Delivery in Disease States

(4)

Photodynamic Therapy

(1)

Future Opportunities and Challenges

(1)

References

(8)

2. Blood–Retinal Barrier

(14)

David A. Antonetti, Thomas W. Gardner, and Alistair J. Barber

Introduction

(1)

Function of the Blood–Retinal Barrier

(1)

Formation of the Blood--Neural Barrier

(1)

Ocular Disease and Loss of the Blood–Retinal Barrier

(1)

Molecular Architecture of the Blood -Retinal Barrier

(1)

Claudins

(1)

Occludin

(2)

Restoring Barrier Properties

(1)

References

(7)

3. Neuroprotection

(18)

Dennis W. Rickman and Melissa J. Mahoney

Introduction

(1)

Excitotoxicity as a Stimulus for Neuronal Cell Death

(2)

Intracellular Effectors of Cell Death

(2)

Oxidative Stress and the Generation of Free Radicals

(1)

Neurotrophins and Neurotrophin Deprivation as a Stimulus for Retinal Cell Death

(1)

Neurotrophins Support the Development and Maintenance of Retinal Ganglion Cells

(1)

Neurotrophins Support the Development of Inner Retinal Circuitry

(1)

Models of Photoreceptor Degeneration and Strategies for Their Treatment

(1)

Neurotrophin Delivery to CNS Tissue

(2)

Summary

(1)

References

(8)

4. Regulatory Issues in Drug Delivery to the Eye

(12)

Lewis J. Gryziewicz and Scott M. Whitcup

Introduction

(1)

Drug Development in the United States

(9)

References

(2)

PART II: SPECIFIC DELIVERY SYSTEMS

5. Antiangiogenic Agents: Intravitreal Injection

(14)

Sophie J. Bakri and Peter K. Kaiser

Introduction

(1)

Intravitreal Injection

(1)

Technique for Intravitreal Injection

(1)

VEGF

(8)

References

(4)

6. Intravitreal Antimicrobials

(12)

Travis A. Meredith

Introduction

(1)

Basic Pharmacokinetics

(2)

Intravitreal Injections

(2)

Therapeutic Concentration Range

(1)

Toxicity

(2)

Characteristics of Selected Antimicrobials

(2)

References

(4)

7. Pharmacologic Retinal Reattachment with INS37217 (Denufosol Tetrasodium), a Nucleotide P2Y2 Receptor Agonist

(14)

Ward M. Peterson

Description of Drug Delivery System

(1)

Spectrum of Diseases

(2)

Mechanism of Action

(1)

Animal Models of Disease Used

100

(1)

Results of Animal Model Studies

101

(4)

Drug Delivery and Distribution

105

(2)

Clinical Study

107

(1)

Future Horizons

108

(1)

References

109

(2)

8. Cell-Based Delivery Systems: Development of Encapsulated Cell Technology for Ophthalmic Applications

111

(18)

Weng Tao, Rong Wen, Alan Laties, and Gustavo D. Aguirre

Description of Encapsulated Cell Technology

111

(5)

Spectrum of Diseases for Which This Delivery System Might Be Appropriate

116

(2)

Animal Models Used to Investigate the Applicability of this Delivery System for the Diseases Mentioned

118

(2)

Pharmacokinetic and Pharmacodynamic Studies Using the Delivery System

120

(1)

Results of Animal Model Studies

120

(4)

Techniques for Implanting or Placing the Implant in Humans

124

(2)

Future Horizons

126

(1)

References

126

(3)

9. Photodynamic Therapy

129

(14)

Ivana K. Kim and Joan W. Miller

Introduction

129

(1)

Preclinical Studies of Verteporfin for Experimental CNV

130

(6)

Other Photosensitizers

136

(1)

Future Directions

137

(2)

References

139

(4)

10. Thermal-Sensitive Liposomes

143

(14)

Sanjay Asrani, Morton F. Goldberg, and Ran Zeimer

Introduction

143

(1)

Methodology of Laser-Targeted Drug Delivery

144

(3)

Potential Therapeutic Applications of LTD

147

(2)

Diagnostic Applications

149

(3)

Safety of Light-Targeted Drug Delivery

152

(1)

Limitations

153

(1)

Conclusion

153

(1)

Disclosure of Financial Interest

154

(1)

Reference

154

(3)

11. Gene Therapy for Retinal Disease

157

(1)

Albert M. Maguire and Jean Bennett

Description of Drug Delivery System

157

(3)

Spectrum of Diseases for Which This Delivery System Might Be Appropriate

160

(2)

Animal Models Used to Investigate the Applicability of This Delivery System for the Diseases Mentioned Above

162

(1)

Pharmacokinetic Studies Using the Delivery System

163

(1)

Results of Animal Model Studies

163

(4)

Techniques for Implanting or Placing the Implant in Humans (If Done)

167

(1)

Future Horizons

168

(1)

References

169

(6)

12. Biodegradable Systems

175

(18)

Hideya Kimura and Yuichiro Ogura

Fundamentals of Biodegradable Polymeric Devices

175

(4)

Spectrum of Diseases for Which Biodegradable Systems May Be Useful

179

(1)

Animal Models Used to Test Biodegradable Drug Delivery Systems

180

(1)

Results of Efficacy Studies

181

(2)

Pharmacokinetic and Pharmacodynamic Studies

183

(6)

Summary and Future Horizons

189

(1)

References

189

(4)

13. Transscleral Drug Delivery to the Retina and Choroid

193

(10)

Jayakrishna Ambati

Introduction

193

(1)

Scleral Anatomy

193

(1)

In Vitro Studies of Scleral Permeability

194

(2)

In Vivo Studies of Scleral Permeability

196

(2)

Future Directions

198

(1)

References

199

(4)

14. Nondegradable Intraocular Sustained-Release Drug Delivery Devices

203

(24)

Mark T. Cahill and Glenn J. Jaffe

Implanted Nondegradable Sustained-Release Devices

203

(13)

Implanted Microdialysis Probes as Sustained-Release Drug Delivery Systems

216

(3)

Microelectromechanical Systems Drug Delivery Devices

219

(3)

References

222

(5)

PART III: LOCAL DRUG DELIVERY APPROACH TO SPECIFIC CLINICAL DISEASES

15. Photodynamic Therapy in Human Clinical Studies: Age-Related Macular Degeneration

227

(22)

Ivana K. Kim and Joan W. Miller

Introduction

227

(1)

Phase III Design and Methodology

227

(4)

Phase III Results

231

(3)

Phase III Design/Methodology

234

(10)

Conclusions

244

(1)

References

245

(4)

16. Age-Related Macular Degeneration Drug Delivery

249

(16)

Kourous A. Rezaei, Sophie J. Bakri, and Peter K. Kaiser

Treatment Modalities for Neovascular AMD

249

(1)

Clinical Trials of Drug Delivery Devices for the Treatment of Neovascular AMD

250

(9)

References

259

(6)

17. Intraocular Sustained-Release Drug Delivery in Uveitis

265

(14)

Mark T. Cahill and Glenn J. Jaffe

Introduction

265

(1)

Corticosteroid Devices

266

(9)

Cyclosporine Devices

275

(1)

Conclusions

276

(1)

References

277

(2)

18. Drug Delivery for Proliferative Vitreoretinopathy: Prevention and Treatment

279

(12)

Stephen J. Phillips and Glenn J. Jaffe

Retinal Detachment/Proliferative Vitreoretinopathy

279

(3)

Systemic

282

(1)

Local Delivery

283

(1)

Direct Injection—Subconjunctival or Intravitreal

283

(3)

Sustained Delivery and Co-Drugs

286

(1)

References

287

(4)

19. Pharmacologic Treatment in Diabetic Macular Edema

291

(10)

Zeshan A. Rana and P. Andrew Pearson

Introduction

291

(1)

Treatment

292

(1)

Corticosteroids

292

(1)

Intravitreal Triamcinolone Acetonide (Kenalog) injection

293

(1)

Intravitreal Fluocinolone Acetonide Implant (Retisert)

294

(1)

Dexarnethasone Implant (Posurdex )

295

(1)

Protein Kinase C Inhibition

296

(1)

VEGF Inhibition

297

(1)

New Agents on the Horizon

297

(1)

References

298

(3)

20. Retinal Vein Occlusion

301

(24)

Michael M. Altaiveel and Michael S. Ip

Local Drug Delivery Approach: Retinal Vein Occlusion

301

(8)

Other Treatments

309

(10)

Summary

319

(1)

References

320

(5)

21. Cytomegalovirus Retinitis

325

(24)

Caroline R. Baumal

Introduction

325

(1)

Virology and Epidemiology of CMV Infection

325

(2)

CMV Retinitis in the Era of HAART

327

(1)

Clinical Features of CMV Retinitis

328

(2)

Diagnosis of CMV Retinitis

330

(1)

Treatment of CMV Retinitis

330

(1)

Systemic Anti-CMV Therapy

331

(2)

Local Modes of Intraocular Drug Delivery

333

(1)

Intravitreal Drug Injection

334

(1)

The Ganciclovir Intraocular Implant

335

(4)

Indications for the Ganciclovir Implant

339

(1)

Replacement of the Ganciclovir Implant

340

(1)

Complications of the Ganciclovir Implant

341

(1)

Summary

342

(1)

References

343

(6)

22. Endophthalmitis

349

(8)

Travis A. Meredith

Overview

349

(1)

Presentation

349

(1)

Predisposing Factors

349

(1)

Bacterial Spectrum

350

(1)

Antimicrobial Therapy

350

(2)

Injection of Intraocular Corticosteroids

352

(1)

Prognosis

353

(1)

Summary

353

(1)

References

353

(4)

Index

357

Please wait while the item is added to your bag...

FREE SHIPPING

Amazon no longer offers textbook rentals. We do!

Intraocular Drug Delivery

Summary

Table of Contents

Supplemental Materials