The Ischemic Penumbra

This source presents the current status of concepts and research on ischemic penumbra and identifies the latest methods for clinicians to quickly and efficiently recognize viable cerebral tissue for enhanced stroke management. Focusing on state-of-the-science technologies and cutting-edge trends, this guide examines imaging strategies utilizing PET, SPECT, MR, and CT for improved identification of key areas for intervention and therapy in the management of stroke patients.

Foreword	p. v
Preface	p. vii
Contributors	p. xi
The Ischemic Penumbra: An Overview
The Ischemic Penumbra-The Beginning	p. 1
The Ischemic Penumbra: Overview, Definition, and Criteria	p. 7
Perfusion Thresholds in Cerebral Ischemia	p. 21
Duration and Thresholds of the Ischemic Penumbra in Different Species	p. 37
The Ischemic Cascade: Events Within the Penumbra	p. 59
Multimodal Mapping of the Ischemic Penumbra in Animal Models	p. 77
Molecular Biology of the Penumbra	p. 93
Selective Neuronal Loss	p. 109
Inflammation and Reperfusion Injury Within the Penumbra	p. 125
Imaging the Penumbra: Other Approaches
Imaging Penumbra and Neuronal Loss: Positron Emission Tomography with Flumazenil	p. 137
Imaging the Penumbra: Positron Emission Tomography Fluoromisonidazole	p. 149
Can the Penumbra Be Imaged Using Single-Photon Emission Computed Tomography?	p. 165
Magnetic Resonance Imaging Assessment of the Ischemic Penumbra in Experimental Stroke	p. 177
Penumbra Imaged with Magnetic Resonance Imaging in Humans	p. 187
Perfusion Computed Tomography and Xenon-Computed Tomography: Current Status and Implications for Therapy	p. 197
Perfusion Computed Tomography	p. 197
Xenon-Computed Tomography-Cerebral Blood Flow Assessment of Ischemic Penumbra in Acute Stroke	p. 207
Magnetic Resonance Imaging of Ischemic Penumbra: New Techniques	p. 219
Gradient Echo	p. 219
"Penumbra" Defined by Magnetic Resonance Imaging: Oxygen Extraction Fraction and Cerebral Metabolic Rate of Oxygen Utilization	p. 222
Arterial Spin Labeling	p. 234
Clinical/Imaging Mismatch as an Index of the Penumbra	p. 241
The Topography of the Ischemic Penumbra	p. 251
The Penumbra and Intracerebral Hemorrhage	p. 263
The Ischemic Penumbra: Implications for Therapy
Extending the Time Window for Therapy	p. 281
Magnetic Resonance in the Selection of Stroke Therapies	p. 307
Index	p. 317
Table of Contents provided by Ingram. All Rights Reserved.

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The Ischemic Penumbra

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Table of Contents

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