Lupus

Leading basic and clinical investigators from around the world summarize the most recent research on the molecular and cellular origins of lupus. Their cutting-edge articles review the mechanisms underlying abnormal immunity and introduce the powerful new concept that a disorder of multiple genes underlies the abnormal immune response, leading directly to the development of lupus. This pathophysiology is shown to involve a wide variety of cell types, including T cells, B cells, natural killer cells, macrophages/monocytes, and endothelial cells. Over time, the resulting long-term inflammation causes irreversible cell destruction and, ultimately, organ failure. Lupus: Molecular and Cellular Pathogenesis is a masterful new synthesis of all the new knowledge emerging today about lupus. Its new perspectives will sharpen the focus of research and ultimately lead to better and more effective treatment.

Steven B. Abramson, MD: Department of Rheumatology, Hospital for Joint Diseases, New York Ashok R. Amin, PhD: Rheumatology Research Laboratory, Hospital for Joint Diseases, New York John P. Atkinson, MD: Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO Katalin Banki, MD: Departments of Medicine and Pathology, State University of New York, Syracuse H. Michael Belmont, MD: Lupus Clinic, Bellevue Hospital, New York, NY Daniel J. Birmingham, PhD: Division of Nephrology, Ohio State University College of Medicine, Columbus Jill P. Buyon, MD: Department of Rheumatology, Hospital for Joint Diseases, New York Livia A. Casciola-Rosen, PhD: Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD Philip L. Cohen, MD: Division of Rheumatology, University of North Carolina, Chapel Hill Joe Craft, MD: Section of Rheumatology, Yale University School of Medicine, New Haven, CT Bruce N. Cronstein, MD: Division of Rheumatology, Department of Medicine, New York University Medical Center, New York Mary K. Crow, MD: Department of Medicine, Hospital of Special Surgery, New York David I. Daikh, MD, PhD: Department of Medicine, Department of Veterans Affairs Medical Center, University of California, San Francisco Ludmila da Silva, MD: Department of Medicine, University of Maryland School of Medicine, Baltimore Syamal K. Datta, MD: Arthritis Division, Northwestern University Medical School, Chicago, IL Betty Diamond, MD: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY Fanny M. Ebling, PhD: Division of Rheumatology, Center for Health Sciences, UCLA School of Medicine Jeffrey C. Edberg, PhD: Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham David A. Fox, MD: Department of Internal Medicine/Rheumatology Division, University of Michigan Medical School, Ann Arbor William C. Gause, PhD: Department of Microbiology/Immunology, Uniformed Services University Health Sciences, Bethesda, MD Andrew W. Gibson, PhD: Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham Gary S. Gilkeson, MD: Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston J. Dixon Gray, PhD: Division of Rheumatology/Immunology, USC School of Medicine, Los Angeles Percio S. Gulko, MD: Division of Autoimmune and Molecular Diseases, Columbia University College of Physicians and Surgeons, New York Bevra H. Hahn, MD: Division of Rheumatology, Center for Health Sciences, UCLA School of Medicine, Los Angeles Mark J. Halvorson, PhD: Department of Microbiology and Immunology, Uniformed Services University of Health Sciences, Bethesda, MD Barry S. Handwerger, MD: Division of Rheumatology, University of Maryland School of Medicine, Baltimore Evelyn V. Hess, MD: Division of Immunology, Department of Medicine, University of Cincinnati College of Medicine, OH Motoko Honda, MD: Cedars-Sinai Medical Center and UCLA School of Medicine, Los Angeles David A. Horwitz, MD: Division of Rheumatology/Immunology, USC School of Medicine, Los Angeles Hui-Chen Hsu, PhD: Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham Lillie Hsu, MD: Division of Rheumatology/Immunology, USC School of Medicine, Los Angeles Gary M. Kammer, MD: Section on Rheumatology, Department of Internal Medicine, The Wake Forest University School of Medicine, Winston-Salem, NC Islam U. Khan, MD: Section on Rheumatology, Department of Internal Medicine, The Wake Forest University School of Medicine, Winston-Salem, NC Robert P. Kimberly, MD: Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham Dennis M. Klinman, MD, PhD: Division of Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD Arthur M. Krieg, MD: Division of Rheumatology, Department of Medicine, University of Iowa, Iowa City Dama Laxminarayana, MD: Section on Rheumatology, Department of Internal Medicine, The Wake Forest University School of Medicine, Winston-Salem, NC Mariana Linker-Israeli, PhD: Cedars-Sinai Medical Center and UCLA School of Medicine, Los Angeles Stamatis-Nick C. Liossis, MD: Department of Clinical Physiology, Walter Reed Army Institute of Research, Washington, DC Irina Luzina, MD, PhD: Division of Rheumatology, University of Maryland School of Medicine, Baltimore Sandeep Malhotra, MD: Department of Surgery, Department of Medicine, New York University School of Medicine Mark J. Mamula, PhD: Section of Rheumatology, Yale University School of Medicine, New Haven, CT W. Joseph McCune, MD: Department of Internal Medicine/Rheumatology Division, University of Michigan Medical School, Ann Arbor Chandra Mohan, MD, PhD: Department of Pathology, Immunology, and Laboratory Medicine, Center for Mammalian Genetics, University of Florida, Gainesville Laurence Morel, PhD: Department of Pathology, Immunology, and Laboratory Medicine, Center for Mammalian Genetics, University of Florida, Gainesville John D. Mountz, MD, PhD: Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham Jeff Newman, MD, PhD: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY Phuong Nguyen, BS: Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore Tho Q. Nguyen, MD: Department of Dermatology, University of Texas Southwestern Medical Center, Dallas Katzuo Ohtsuka, MD: Division of Rheumatology/Immunology, USC School of Medicine, Los Angeles Stanford L. Peng, MD: Section of Rheumatology, Yale University School of Medicine, New Haven, CT Andras Perl, MD, PhD: Division of Rheumatology, Department of Medicine, State University of New York, Syracuse David S. Pisetsky, MD: Division of Rheumatology, Department of Medicine, Durham VA Hospital, Durham, NC Doina Racila, MD: Department of Dermatology, University of Texas Southwestern Medical Center, Dallas Westley H. Reeves, MD: Division of Rheumatology, Thurston Arthritis Center, University of North Carolina School of Medicine, Chapel Hill Morris Reichlin, MD: Division of Arthritis/Immunology, Oklahoma Medical Research Foundation, Oklahoma City Allison Reiss, MD: Department of Medicine, New York University School of Medicine, New York Hanno B. Richards, MD: Departments of Medicine and Microbiology/Immunology, Thurston Arthritis Research Center and UNC Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill Bruce C. Richardson, MD, PhD: Arthritis Division, University of Michigan Medical Center, Ann Arbor Noel R. Rose, MD, PhD: Departments of Pathology and Molecular Microbiology and Immunology, The Johns Hopkins Medical Institutions, Baltimore, MD Antony Rosen, MD: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD Robert A. S. Roubey, MD: Division of Rheumatology, Thurston Arthritis Center, University of North Carolina School of Medicine, Chapel Hill Violetta Rus, MD: Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore Minoru Satoh, MD: Departments of Medicine and Microbiology/Immunology, Thurston Arthritis Research Center and UNC Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill Jurg A. Schifferli, MD: Medizinische Universitatsklinik B, Basel, Switzerland Jeannine M. Scott, PhD: Department of Human Genetics, University of Michigan Medical Center, Ann Arbor Andrei Shustov, MD: Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore Ram R. Singh, MD: Division of Rheumatology, Department of Medicine, Center for Health Sciences, UCLA School of Medicine, Los Angeles Richard D. Sontheimer, MD: Department of Dermatology, University of Texas Southwestern Medical Center, Dallas Mary M. Stimmler, MD: Division of Rheumatology/Immunology, USC School of Medicine, Los Angeles William Stohl, MD, PhD: Division of Rheumatology/Immunology, USC School of Medicine, Los Angeles Catherine E. Storrer, BS: Division of Rheumatology, University of Maryland School of Medicine, Baltimore Bricia Toro, MD: Division of Rheumatology/Immunology, USC School of Medicine, Los Angeles Betty P. Tsao, PhD: Division of Rheumatology, Department of Medicine, Center for Health Sciences, UCLA School of Medicine, Los Angeles George C. Tsokos, MD: Division of Rheumatology and Immunology, Uniformed Services University of Health Sciences, Bethesda, MD: Department of Clinical Physiology, Walter Reed Army Institute of Research, Washington, DC Rebecca S. Tuetken, MD: Interdisciplinary Graduate Program in Immunology, Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City Daniela Verthelyi, MD, PhD: Division of Rheumatology, University of Maryland and Drug Administration, Bethesda, MD Charles S. Via, MD, PhD: Division of Rheumatology, University of Maryland School of Medicine, Baltimore Edward K. Wakeland, PhD: Department of Pathology, Immunology, and Laboratory, Center for Mammalian Genetics, University of Florida, Gainesville Mark H. Wener, MD: Division of Rheumatology, University of Washington School of Medicine, Seattle Robert J. Winchester, MD: Division of Autoimmune and Molecular Diseases, Columbia University College of Physicians and Surgeons, New York David Wofsy, MD: Arthritis-Immunology, VA Medical Center, San Francisco, CA Jianming Wu, PhD: Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham Ae-Kyung Yi, PhD: Interdisciplinary Graduate Program in Immunology, Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City Huang-Ge Zhang, DVM, PhD: Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham Tong Zhou, MD: Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham Robert B. Zurier, MD: Division of Rheumatology, University of Massachusetts School of Medicine, North Worcester