Note: Supplemental materials are not guaranteed with Rental or Used book purchases.
- ISBN: 9780824754426 | 0824754425
- Cover: Hardcover
- Copyright: 6/9/2005
It was once assumed that mitochondrial diseases were rare and that few people were affected. As knowledge has grown about these organelles and their function, it became clear that mitochondrial malfunction could be linked to several chronic diseases. Diabetes has been associated with DNA mutation and can cause mutation itself. This text discusses findings involving the effects of disease on mitochondrial number, mitogenesis, and the base sequence of mitochondrial DNA. Experts discuss their study of mitochondria and what happens when it malfunctions. This book also explores the idea that mutated mitochondrial DNA can result in disease, and vice versa.
Chapter 1 Introduction to Mitochondria | 1 | (64) | |||
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Chapter 2 Mitochondrial Bioenergetics in Intact Tissue | 65 | (30) | |||
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Chapter 3 The Human Mitochondrial Genome: Mechanisms of Expression and Maintenance | 95 | (152) | |||
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Chapter 4 Oxidative Phosphorylation Disease: Diagnosis and Pathogenesis | 247 | (54) | |||
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Chapter 5 Using Mitochondrial DNA in Population Surveys | 301 | (18) | |||
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Chapter 6 Mitochondrial DNA Mutation, Oxidative Stress, and Alteration of Gene Expression in Human Aging | 319 | (44) | |||
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Chapter 7 Mitochondrial DNA in Cardiomyopathies | 363 | (14) | |||
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Chapter 8 Mitochondria in Diabetes Mellitus | 377 | (78) | |||
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Chapter 9 Drugs, Nutrients, and Hormones in Mitochondrial Function | 455 | (52) | |||
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Chapter 10 Bacterial F1F0 ATP Synthase as a Model for Complex V | 507 | (32) | |||
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Chapter 11 Cybrids in the Study of Animal Mitochondrial Genetics and Pathology | 539 | (20) | |||
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Chapter 12 Animal Modeling: From Transgenesis to Transmitochondrial Models | 559 | (22) | |||
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563 | (9) | |||
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Chapter 13 BHE/Cdb Rats as Tools to Study Mitochondrial Gene Expression | 581 | (24) | |||
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Appendix 1 | 605 | (2) | |||
Appendix 2 | 607 | (8) | |||
Index | 615 |
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