Molecular Cell Biology

With its acclaimed author team, cutting-edge content, emphasis on medical relevance, and coverage based on landmark experiments,Molecular Cell Biologyhas justly earned an impeccable reputation as an authoritative and exciting text. The new Sixth Edition features two new coauthors, expanded coverage of immunology and development, and new media tools for students and instructors.

Harvey Lodish is Professor of Biology and Professor of Bioengineering at the Massachusetts Institute of Technology and a member of the Whitehead Institute for Biomedical Research. Dr. Lodish is also a member of the National Academy of Sciences and the American Academy of Arts and Sciences and was President (2004) of the American Society for Cell Biology. He is well known for his work on cell membrane physiology, particularly the biosynthesis of many cell-surface proteins, and on the cloning and functional analysis of several cell-surface receptor proteins, such as the erythropoietin and TGF-ß receptors. His lab also studies hematopoietic stem cells and has identified novel proteins that support their proliferation. Dr. Lodish teaches undergraduate and graduate courses in cell biology and biotechnology. Arnold Berk is Professor of Microbiology, Immunology and Molecular Genetics and a member of the Molecular Biology Institute at the University of California, Los Angeles. Dr. Berk is also a fellow of the American Academy of Arts and Sciences. He is one of the original discoverers of RNA splicing and of mechanisms for gene control in viruses. His laboratory studies the molecular interactions that regulate transcription nitiation in mammalian cells, focusing particular attention on transcription factors encoded by oncogenes and tumor suppressors. He teaches introductory courses in molecular biology and virology and an advanced course in cell biology of the nucleus. Chris A. Kaiser is Professor and Head of the Department of Biology at the Massachusetts Institute of Technology. His laboratory uses genetic and cell biological methods to understand the basic processes of how newly synthesized membrane and secretory proteins are folded and stored in the compartments of the secretory pathway. Dr. Kaiser is recognized as a top undergraduate educator at MIT, where he has taught genetics to undergraduates for many years.  Monty Krieger is the Whitehead Professor in the Department of Biology at the Massachusetts Institute of Technology. For his innovative teaching of undergraduate biology and human physiology as well as graduate cell biology courses, he has received numerous awards. His laboratory has made contributions to our understanding of membrane trafficking through the Golgi apparatus and has cloned and characterized receptor proteins important for the movement of cholesterol into and out of cells, including the HDL receptor.  Matthew P. Scott is Professor of Developmental Biology, Genetics and Bioengineering at Stanford University School of Medicine and Investigator at the Howard Hughes Medical Institute. He is a member of the National Academy of Sciences and the American Academy of Arts and Sciences and a past president of the Society for Developmental Biology. He is known for his work in developmental biology and genetics, particularly in areas of cell-cell signaling and homeobox genes and for discovering the roles of developmental regulators in cancer. Dr. Scott teaches cell and developmental biology to undergraduate students, development and disease mechanisms to medical students and developmental biology to graduate students at Stanford University. Anthony Bretscher is Professor of Cell Biology at Cornell University. His laboratory is well known for identifying and characterizing new components of the actin cytoskeleton, and elucidating their biological functions in relation to cell polarity and membrane traffic. For this work, his laboratory exploits biochemical, genetic and cell biological approaches in two model systems, vertebrate epithelial cells and the budding yeast. Dr. Bretscher teaches cell biology to graduate students at Cornell University. Hidde Ploegh is Professor of Biology at the Massachusetts Institute of Technology and a member of the Whitehead Institute for Biomedical Research. One of the world’s leading researchers in immune system behavior, Dr. Ploegh studies the various tactics that viruses employ to evade our immune responses, and the ways in which our immune system distinguishes friend from foe. Dr. Ploegh teaches immunology to undergraduate students at Harvard University and MIT.

Part I Chemical and Molecular Foundations
1. Life Begins with Cells
2. Chemical Foundations
3. Protein Structure and Function Part II Genetics and Molecular Biology
4. Basic Molecular Genetic Mechanisms
5. Molecular Genetic Techniques
6. Genes, Genomics, and Chromosomes
7. Transcriptional Control of Gene Expression
8. Post-transcriptional Gene Control Part III Cell Structure and Function
9. Visualizing, Fractionating, and Culturing Cells
10. Biomembrane Structure
11. Transmembrane Transport of Ions and Small Molecules
12. Cellular Energetics
13. Moving Proteins into Membranes and Organelles
14. Vesicular Traffic, Secretion, and Endocytosis
15. Cell Signaling I: Signal Transduction and Short-term Cellular Responses
16. Cell Signaling II: Signaling Pathways that Control Gene Activity
17. Cell Organization and Movement I: Microfilaments
18. Cell Organization and Movement II: Microtubules and Intermediate Filaments
19. Integrating Cells into Tissues Part IV Cell Growth and Development
20. Regulating the Eukaryotic Cell Cycle
21. Cell Birth, Lineage, and Death
22. The Molecular Cell Biology of Development
23. Nerve Cells
24. Immunology
25. Cancer