Multicomponent Reaction Chemistry A Practical Approach

Written by one of the world's leading experts in the field, this is the only book available to adopt a practical approach, presenting the most common and successful experimental procedures used in MCR.
As such, the book guides readers through the overwhelming amount of literature and points to the best procedures for gaining optimum results for the attempted synthesis. A small theoretical overview is presented and practical procedures described for each reaction covered. The examples are chosen from drug and natural product synthesis, parallel synthesis as well as drug discovery methods based on virtual screening of MCR-based libraries.
With its workable procedures this practical text is perfect for bench chemists working in the pharmaceutical and industrial chemistry, and can equally be used in an advanced organic chemistry or specialized course at universities.

Alexander Domling studied Chemistry and Biology at the Technical University Munich, Germany. After obtaining his PhD under the supervision of Ivar Ugi, he spent a postdoctoral year at the Scripps Research Institute in La Jolla (USA) in the group of Nobel Laureate Barry Sharpless. In 2004 he performed his habilitation at the Technical University of Munich. Since 2006 he teaches and performs research at the University of Pittsburgh in the Department of Pharmacy with secondary appointments in Chemistry and Computational Biology. In 2010 he became full professor receiving his tenure in Pittsburgh. Since 2011 he is chairing the department of Drug Design at the University of Groningen/The Netherlands. Dr. Domling is founder of several biotech companies, including Morphochem and Carmolex. His research centers around the discovery of antagonists of protein-protein interactions and other biologically active compounds in the therapeutic areas of oncology, infectious and neglected tropical diseases using "out-of-the-box" software tools and multicomponent reaction chemistries.

Introduction to MCR
Isocyanide based MCR
Non isocyanide based MCR
Virtual Screening of MCR libraries
Chip based MCR
Polymers with MCR
References