Neonatal and Pediatric Pharmacology Therapeutic Principles in Practice

Written by experts at the forefront of current research and clinical practice, this volume provides evidence-based guidelines for safe, effective, and rational drug therapy in newborns, children, and adolescents. Includes updated information on drug interactions and regulatory issues.

I: GENERAL PRINCIPLES 1: Introduction and Historical Perspectives 2: Clinical Pharmacokinetics in Infants and Children 3: Drug Action and Therapy in the Infant and Child 4: Drug Metabolism and Disposition in Infants and Children 5: Pharmacogenetics, Pharmacogenomics, and Pharmacoproteomics 6: Compliance with Pediatric Medication Regimens 7: Clinical Trials Involving Children: History, Rationale, Regulatory Framework, and Technical Considerations 8: Ethics of Drug Research in Pediatric Populations 9: Therapeutic Drug Monitoring 10: Drug Formulations II: DRUGS AND THE NEWBORN 11: Developmental Toxicology 12: Biotransformation of Medications by Human Placenta 13: Maternal Drug Intake and the Newborn 14: Principles of Neonatal Pharmacology 15: Perinatal Origins of Adult Defects in Drug Metabolism 16: Renal Function and Excretion of Drugs in the Newborn 17: The Excretion of Drugs and Chemicals in Human Milk 18: Drugs for Hyperbilirubinemia 19: Drugs and Lung Development 20: Pharmacologic Treatment of Neonatal Apnea 21: Drugs and Perinatal Brain Injury 22: Antiretroviral Pharmacology in Pregnant Women and Newborns III: DRUGS IN SPECIAL POPULATIONS AND SETTINGS 23: Therapeutic Applications in Pediatric Intensive Care 24: Drug Therapy in the Pediatric Emergency Department 25: Drug Therapy in the Adolescent 26: Topical Medications 27: Ophthalmologic Drugs in Infants and Children IV: SPECIFIC DRUGS 28: Sulfonamides 29: Penicillins, Cephalosporins, and Other Beta-Lactams 30: Aminoglycosides and Glycopeptides 31: Fluoroquinolones 32: Macrolides, Chloramphenicol, and Tetracyclines 33: Anthelminthic Drugs in Children 34: Antituberculosis Drugs 35: Antifungal Agents 36: Antiviral Drugs: Treatment of the Fetus and Newborn 37: Anticonvulsants 38: Psychopharmacology in Children and Adolescents 39: Antihistamine Drugs 40: Antiasthmatics 41: Antipyretics 42: Cardiovascular Drugs 43: Diuretics 44: Clinical Pharmacology of Antineoplastic Drugs 45: Immunosuppressive and Immunomodulatory Drugs 46: Analgesic Agents 47: Local Anesthetics for Infants and Children 48: Nonsteroidal Anti-inflammatory Drugs 49: Antihypertensive Agents 50: Gastrointestinal Drugs 51: Glucocorticoids 52: Insulin and Diabetes Mellitus 53: Thyroid Hormones 54: Growth Hormone 55: Hematologic Agents 56: Nutrient Supplements 57: Childhood Vaccines V: ADVERSE DRUG EFFECTS AND INTERACTIONS 58: Epidemiology of Adverse Drug Effects 59: Mechanisms of Adverse Drug Reactions 60: Medication Errors 61: Pediatric Poisonings and Antidotes 62: Use of Herbal Products in Children: Risks and Unproven Benefits 63: Neonatal Abstinence Syndromes 64: Drug Interactions in Newborns and Children VI: APPENDIX 65: Drug Formulary for the Newborn 66: Pediatric Drug Formulary