Neurobehavioral Toxicology: Neurological and

This is the final volume in a three-volume work that has addressed the scientific methodologies relevant to clinical neurobehavioral toxicology. Volume I focused on basic concepts and methodologies in Neurobehavioral Toxicology, with Volume II focusing on the peripheral nervous system. Volume III attends to what is known about industrial and environmental chemicals, medicines, and substances of abuse and how these agents affect the central nervous system. All substances have the capacity to be toxic, depending on factors that include the physical properties of the chemical or compound, organism related variables, or interaction between the two. These substances on the other hand and as a result of these same factors might be used therapeutically or even recreationally. The difference between medicine, recreational drug, or poison depends often on a careful balance between adverse and intended effects. How to determine that a specified substance has caused harm is emphasized in the present volume by wayof case examples and discussion. Illnesses and behavioral variations that compete with toxicant-induced explanations for findings in a given case, as well as the various controversies that can arise around issues of diagnosis and causal determination, are treated comprehensively in this volume.

Contents of Volume I	p. ix
Contents of Volume II	p. xiii
About the Primary Authors	p. xvii
Guest Contributors	p. xix
Acknowledgments	p. xxi
Disclosures	p. xxiii
From the Series Editor	p. xxv
Authors' Preface to Volume III	p. xxvii
Industrial and Environmental Agents	p. 735
Selected presentations	p. 737
Carbon monoxide poisoning	p. 737
Lead in adults	p. 746
Lead in children	p. 754
Organic mercury	p. 778
Pesticides	p. 790
Solvents	p. 801
Summary	p. 815
Medications and Substances of Abuse	p. 835
Selected presentations	p. 835
Anticonvulsants	p. 835
Amphetamines	p. 846
Clioquinol	p. 857
Corticosteroids	p. 879
Cyclosporine	p. 893
Ethyl alcohol	p. 902
Hypnotics and sedatives	p. 923
Lithium	p. 932
Pain medications (opioids)	p. 941
Psychotropic medications (chlorpromazine)	p. 952
Toluene	p. 960
Summary	p. 970
Conditions Associated with or Sometimes Mimic Toxic-Induced Central Nervous System Disease	p. 999
The influence of aging on clinical and psychometric examinations	p. 999
Issues of accommodation in evaluating the elderly	p. 1002
Issues of bias	p. 1004
Normative data in the context of age	p. 1005
Models of cognitive change in aging	p. 1010
Conclusion	p. 1013
Psychological and emotional considerations in central nervous system disease	p. 1014
Case presentation	p. 1014
Discussion	p. 1015
The importance of understanding normal behavior	p. 1016
When is behavior abnormal?	p. 1017
Models of abnormality	p. 1018
The formal diagnosis of psychopathology	p. 1019
Anxiety	p. 1020
Mood disorders	p. 1032
Somatoform disorder	p. 1039
Other psychological/psychiatric considerations	p. 1055
Neurological or medical conditions associated with or mimicking toxic-induced central nervous system disease	p. 1066
Dementia	p. 1066
Headache	p. 1081
Hepatic encephalopathy	p. 1093
Hypothyroidism	p. 1100
Hypoxic encephalopathy	p. 1112
Parkinson's disease and parkinsonism	p. 1129
Summary	p. 1145
Consequences of an Incomplete Differential Diagnosis	p. 1171
Selected presentations	p. 1171
Child with behavioral and learning problems attributed to ethylmercury	p. 1171
Depression in a chronic medical condition	p. 1187
Neurobehavioral complaints attributed to mold exposure	p. 1192
Patient with neurobehavioral symptoms attributed to dental amalgams	p. 1208
Patient with history of head injury	p. 1224
Patient with neuropsychological complaints attributed to diet drugs	p. 1234
Patient with presumed arsenic-induced neurotoxicity	p. 1242
Solvent-exposed mechanic with dementia	p. 1252
Solvent-exposed machinist with behavioral and neurological complaints	p. 1263
Summary	p. 1282
Issues and Controversies Involving the Central Nervous System Evaluation	p. 1311
The complexity of the neurobehavioral examination	p. 1311
Patient with toxic exposure and multiple explanations for his complaints	p. 1311
Factors influencing the evaluation	p. 1319
Individual differences	p. 1319
Other considerations that influence or even explain the patient's complaints and examination findings	p. 1320
Approaching the differential diagnosis from a neurobehavioral perspective	p. 1332
The role of neuropsychological testing in the examination	p. 1333
The importance of ancillary test results	p. 1335
The importance of the patient history and interview	p. 1336
Establishing causation in clinical neurotoxicological investigations	p. 1337
Controversial neurotoxic disorders involving the central nervous system	p. 1339
Summary	p. 1347
Appendix	p. 1353
Index	p. 1355
Table of Contents provided by Ingram. All Rights Reserved.

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Neurobehavioral Toxicology: Neurological and Neuropsychological Perspectives VOLUME: III Central Nervous System

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