The Neuron Cell and Molecular Biology

The Fourth Edition of The Neuron provides a comprehensive first course in the cell and molecular biology of nerve cells. The book begins with properties of the many newly discovered ion channels that have emerged through mapping of the genome. These channels shape the way a single neuron generates varied patterns of electrical activity. Covered next are the molecular mechanisms that convert electrical activity into the secretion of neurotransmitter hormones at synaptic junctions between neurons. The following section examines the biochemical pathways that are linked to the action of neurotransmitters and that can alter the cellular properties of neurons or sensory cells that transduce information from the outside world into the electrical code used by neurons. The final section reviews our rapidly expanding knowledge of the molecular factors that induce an undifferentiated cell to become a neuron, and then guide it to form appropriate synaptic connections with its partners. This section also focuses on the role of ongoing experience and activity in shaping these connections, and finishes with an account of mechanisms thought to underlie the phenomena of learning and memory. The book contains scores of color figures and fully updated chapters; online content packaged exclusively with the Fourth Edition includes detailed animations of neural processes, in-depth supplemental reading, and additional full-color figures and tables.

Irwin B. Levitan, Ph.D., Founding Chair of the Department of Neuroscience at Jefferson Medical College, Thomas Jefferson University

Leonard K. Kaczmarek, Ph.D., Professor of Pharmacology and Cellular and Molecular Physiology, Yale University School of Medicine.

Preface to the Fourth Edition

I. Introduction
1. Signaling in the Brain
2. Form and Function in Cells of the Brain

II. Electrical Properties of Neurons
3. Electrical Signaling in Neurons
4. Membrane Ion Channels and Ion Currents
5. Ion Channels Are Membrane Proteins
6. Ion Channels, Membrane Ion Currents, and the Action Potential
7. Diversity in the Structure and Function of Ion Channels

III. Intercellular Communication
8. Intercellular Communication: How Neurons Communicate: Gap Junctions and Neurosecretion
9. Synaptic Release of Neurotransmitters
10. Neurotransmitters and Neurohormones
11. Receptors and Transduction Mechanisms I: Receptors Coupled Directly to Ion Channels
12. Receptors and Transduction Mechanisms II: Indirectly Coupled Receptor/Ion Channel Systems
13. Sensory Receptors

IV. Behavior and Plasticity
14. The Birth and Death of a Neuron
15. Neuronal Growth and Trophic Factors
16. Adhesion Molecules and Axon Pathfinding
17. Formation, Maintenance, and Plasticity of Chemical Synapses
18. Intrinsic Neuronal Properties, Neural Networks and Behavior
19. Learning and Memory