Nonhuman Primates in Biomedical Research :

This volume and its companion Nonhuman Primates in Biomedical Research: Biology and Management represent the most comprehensive publications of their type on nonhuman primates. This volume addresses the diseases of nonhuman primates with an emphasis on the etiological factors, clinical signs, diagnostic pathology, therapy, and management. Its companion volume serves as a general reference for those who provide care for these animals and for those who use them in biomedical research.

List of Contributors

vii

(2)

Preface

ix

(2)

List of Reviewers for Chapters in This Volume

xi

Chapter 1 Viral Diseases

1

(58)

Keith Mansfield

Norval King

I. Introduction

1

(1)

II. Diseases Caused by Enveloped DNA Viruses

2

(14)

III. Nonenveloped DNA-Containing Viruses

16

(6)

IV. Enveloped RNA-Containing Viruses

22

(22)

V. Nonenveloped RNA-Containing Viruses

44

(4)

VI. References

48

(11)

Chapter 2 Bacterial and Mycotic Diseases

52

(59)

Susan V. Gibson

I. Introduction

60

(1)

II. Bacterial Diseases

60

(31)

III. Mycotic Diseases

91

(11)

References

102

(9)

Chapter 3 Parasitic Diseases

111

(96)

John D. Toft, II

Mark L. Eberhard

I. Introduction

111

(2)

II. Protozoan Parasites

113

(20)

III. Metazoan Parasites

133

(46)

References

179

(28)

Chapter 4 Neoplasia/ Proliferative Disorders

207

(26)

Richard E. Weller

I. Introduction

208

(1)

II. Classification of Neoplasia

208

(4)

III. Etiology and Epidemiology

212

(4)

IV. Mechanisms of Carcinogenesis

216

(1)

V. Description of Tumors

217

(4)

VI. Treatment and Prognosis

221

(5)

VII. Lesions That Stimulate Neoplasms

226

(1)

References

227

(6)

Chapter 5 Environmental Hazards

233

(12)

Ann S. Line

I. Introduction

233

(1)

II. Hazards Associated with Cage Design or Condition

234

(1)

III. Cold-Related Injuries

235

(2)

IV. Heat-Related Injuries

237

(2)

V. Exposure to Other Toxins

239

(3)

References

242

(3)

Chapter 6 Cardiovascular and Lymphoreticular Systems

245

(18)

Milton April

James C. Keith, Jr

I. Introduction

245

(1)

II. Hematology

246

(5)

III. The Heart

251

(4)

IV. Diseases of the Great Vessels

255

(2)

V. Hypertension

257

(1)

VI. Lymphoreticular System

258

(1)

References

258

(5)

Chapter 7 Respiratory Diseases

263

(48)

Kent G. Osborn

Linda J. Lowenstine

I. Introduction

264

(1)

II. Respiratory System Structure and Function

264

(6)

III. Approach to the Patient with Respiratory Diseases

270

(4)

IV. Upper Airway Diseases

274

(4)

V. Lower Respiratory Tract Diseases

278

(4)

VI. Disorders of the Diaphragm, Pleura, and Mediastinum

282

(1)

VII. Viral Diseases

283

(8)

VIII. Bacterial Diseases and Agents

291

(5)

IX. Mycotic Diseases

296

(3)

X. Protozoan Diseases

299

(1)

XI. Metazoan Parasites

300

(3)

References

303

(8)

Chapter 8 Urogenital System

311

(52)

Elizabeth W. Ford

Jeffrey A. Roberts

Janice L. Southers

Part A. Urinary System

312

(12)

Jeffrey A. Roberts

Elizabeth W. Ford

Janice L. Southers

I. Anatomy

312

(1)

II. Clinical Assessment

313

(2)

III. Renal Diseases

315

(4)

IV. Urolithiasis and Renal Calcification

319

(1)

V. Cystitis

319

(1)

VI. Congenital Malformations

320

(1)

VII. Neoplastic Diseases

321

(1)

References

322

(2)

Part B. Genital System

324

(39)

Elizabeth W. Ford

Jeffrey A. Roberts

Janice L. Southers

I. Genital System: Female, Nonpregnant

324

(1)

II. Gynecological Assessment

325

(2)

III. Disorders and Diseases

327

(6)

IV. Endometriosis

333

(3)

V. Disorders of Menstruation

336

(1)

VI. Obstetrical Problems

337

(15)

VII. Genital System: Male

352

(3)

References

355

(8)

Chapter 9 Integumentary System

363

(14)

Joseph T. Bielitzki

I. Introduction

363

(1)

II. Structure and Function of the Skin

364

(1)

III. Definitions and Descriptions of Changes to the Skin

365

(1)

IV. Examination of the Skin

366

(1)

V. Diseases of the Skin

367

(4)

References

371

(6)

Chapter 10 Digestive System

377

(38)

Alan G. Brady

Daniel G. Morton

I. Introduction: Diagnosis and Treatment of Gastrointestinal Diseases

378

(1)

II. Oral Cavity

378

(8)

III. Pharynx, Esophagus, and Stomach

386

(3)

IV. Small and Large Intestine

389

(12)

V. Liver

401

(5)

VI. Exocrine Pancreas

406

(1)

References

407

(8)

Chapter 11 Diseases of the Musculoskeletal System

415

(46)

Kenneth P.H. Pritzker

Matt J. Kessler

I. Introduction

416

(1)

II. Arthritis

416

(15)

III. Connective Tissue Disorders

431

(1)

IV. Skeletal Muscle Diseases

432

(1)

V. Bone Diseases

433

(11)

VI. Musculoskeletal Neoplasia

444

(1)

References

444

(17)

Chapter 12 Nervous System

461

(24)

P.K. Cusick

S.J. Morgan

I. Introduction

461

(1)

II. Overview of Neuroanatomy

462

(1)

III. Neurons

463

(3)

IV. Astrocytes

466

(2)

V. Oligodendroglia and Schwann Cells

468

(2)

VI. Microglia

470

(1)

VII. Blood-Brain Barrier

471

(1)

VIII. Naturally Occurring Conditions

472

(4)

IX. Prominent Models of Human Diseases

476

(3)

References

479

(6)

Chapter 13 Behavioral Disorders

485

(16)

Kathryn Bayne

Melinda Novak

I. Introduction

486

(1)

II. Historical Review of Abnormal Behavior in Captive Nonhuman Primates

487

(1)

III. Etiology of Psychological Disorders

488

(4)

IV. Clinical Signs of Psychological Disorders

492

(1)

V. Diagnosis of Psychological Disorders

493

(1)

VI. Therapeutic Strategies for Reversing Psychopathology

493

(3)

VII. Prevention of Behavioral Pathology

496

(1)

VIII. Summary

497

(1)

References

497

(4)

Index

501

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Nonhuman Primates in Biomedical Research : Diseases

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