Nutritional Genomics Discovering the Path to Personalized Nutrition
, by Kaput, Jim; Rodriguez, Raymond L.Note: Supplemental materials are not guaranteed with Rental or Used book purchases.
- ISBN: 9780471683193 | 0471683191
- Cover: Hardcover
- Copyright: 5/5/2006
The definitive guide to the basic principles and latest advances in Nutritional Genomics Though still in its infancy, nutritional genomics, or "nutrigenomics," has revealed much about the complex interactions between diet and genes. But it is in its potential applications that nutrigenomics promises to revolutionize the ways we manage human health and combat disease in the years ahead. Great progress already has been made in modeling "personalized" nutrition for optimal health and longevity as well as in genotype-based dietary interventions for the prevention, mitigation, or possible cure of a variety of chronic diseases and some types of cancer. Topics covered include: * Nutrients and gene expression * The role of metabolomics in individualized health * Molecular mechanisms of longevity regulation and calorie restriction * Green tea polyphenols and soy peptides in cancer prevention * Maternal nutrition and fetal gene expression * Genetic susceptibility to heterocyclic amines from cooked foods * Bioinformatics and biocomputation in nutrigenomics * The pursuit of optimal diets Written by an all-star team of experts from around the globe, this volume provides an integrated overview of the cutting-edge field of nutritional genomics. The authors and editors lead an in-depth discussion of the fundamental principles and scientific methodologies that serve as the foundation for nutritional genomics and explore important recent advances in an array of related disciplines. Each self-contained chapter builds upon its predecessor, leading the reader seamlessly from basic principles to more complex scientific findings and experimental designs. Scientific chapters are carefully balanced with those addressing the social, ethical, regulatory, and commercial implications of nutrigenomics.
Jim Kaput, PhD, is the founder, President, and Chief Scientific Officer of NutraGenomics, Inc.
Raymond L. Rodriguez, PhD, is Professor of Molecular and Cellular Biology and Director of the Centerof Excellence in Nutritional Genomics at the University of California, Davis.
Contributors | xv | ||||
Foreword | xix | ||||
Preface | xxi | ||||
Acknowledgments | xxv | ||||
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10 MATERNAL NUTRITION: NUTRIENTS AND CONTROL OF EXPRESSION | 219 | (36) | |||
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11 NUTRIENT—GENE INTERACTIONS INVOLVING SOY PEPTIDE AND CHEMOPREVENTIVE GENES IN PROSTATE EPITHELIAL CELLS | 255 | (22) | |||
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12 ENZYMES LOSE BINDING AFFINITY (INCREASED KM) FOR COENZYMES AND SUBSTRATES WITH AGE: A STRATEGY FOR REMEDIATION | 277 | (18) | |||
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13 DIETARY AND GENETIC EFFECTS ON ATHEROGENIC DYSLIPIDEMIA | 295 | (10) | |||
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14 GENISTEIN AND POLYPHENOLS IN THE STUDY OF CANCER PREVENTION: CHEMISTRY, BIOLOGY, STATISTICS, AND EXPERIMENTAL DESIGN | 305 | (26) | |||
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15 SUSCEPTIBILITY TO EXPOSURE TO HETEROCYCLIC AMINES FROM COOKED FOOD: ROLE OF UDP-GLUCURONOSYLTRANSFERASES | 331 | (22) | |||
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16 THE INFORMATICS AND BIOINFORMATICS INFRASTRUCTURE OF A NUTRIGENOMICS BIOBANK | 353 | (22) | |||
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17 BIOCOMPUTATION AND THE ANALYSIS OF COMPLEX DATA SETS IN NUTRITIONAL GENOMICS | 375 | (28) | |||
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18 CULTURAL HUMILITY: A CONTRIBUTION TO HEALTH PROFESSIONAL EDUCATION IN NUTRIGENOMICS | 403 | (16) | |||
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19 NUTRIENTS AND NORMS: ETHICAL ISSUES IN NUTRITIONAL GENOMICS | 419 | (16) | |||
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Glossary | 435 | (12) | |||
Index | 447 |
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